Version 1.5, revision planned in 2013.
Last revised in March 2009
November 2010 — minor update. Advice regarding the effect of major changes in diet on anticoagulation has been reworded. Issued in November 2010.
January 2010 — minor update to include recent changes to warfarin safety information issued by the Medicines and Healthcare products Regulatory Agency (MHRA) [MHRA, 2009b]. Issued in January 2010.
December 2009 — minor update. Advice about taking antidepressants in people receiving warfarin has been amended in the section on Drug interactions. Issued in December 2009.
August to September 2009 — updated to include recommendations and supporting evidence on the place of self-testing and self-management of warfarin. Advice on the management of the drug interaction between SSRIs and warfarin has also been added. Issued in November 2009.
July 2009 — updated to include target INRs and duration of treatment for all indications for warfarin. A change to the recommendation concerning management of potential drug interaction between warfarin and macrolide antibiotics has also been made. Issued in July 2009.
December 2008 to March 2009 — this is a new CKS topic. The evidence-base has been reviewed in detail, and recommendations are clearly justified and transparently linked to the supporting evidence.