Print Print
CKS is no longer commissioned by the National Institute for Health and Clinical Excellence (NICE). NICE remains committed to providing a replacement service for CKS and is currently reviewing its options. In the meantime, although CKS content is now not being maintained, it still remains relevant and will continue to be made available. CKS content was generated under a programme of topic creation and update. To check if the topic you are viewing is current or out of date, please refer to the topic publication details by clicking on the 'How up-to-date is this topic?' link in the left hand menu on individual topic pages.

Bites - human and animal - Management
When should I give tetanus prophylaxis?

  • Give tetanus prophylaxis as follows:
    • Person fully immunized, i.e. has received five doses of vaccine at appropriate intervals: tetanus booster not needed. Consider giving human tetanus immunoglobulin for tetanus-prone wounds where the risk of infection is especially high, e.g. those contaminated with manure or extensive devitalized tissue.
    • Primary immunization complete, boosters incomplete but up-to-date: tetanus booster not needed but may be given if booster is due and it is convenient to give now. Consider giving human tetanus immunoglobulin for tetanus-prone wounds where the risk of infection is especially high, e.g. those contaminated with manure or extensive devitalized tissue.
    • Primary immunization incomplete, or boosters not up-to-date: give tetanus booster and further doses as needed to complete the recommended schedule (note: if the primary course is interrupted it should be resumed but not repeated). Add human tetanus immunoglobulin if it is a tetanus-prone wound (defined as: a puncture wound; a significant degree of devitalized tissue; contaminated with soil or manure; containing foreign bodies; compound fractures; clinical signs of sepsis; wounds or burns sustained more than 6 hours before surgical treatment). Note: inject tetanus vaccine and immunoglobulin at different sites.
    • Not immunized or immunization status uncertain: give an immediate dose of vaccine. Add human tetanus immunoglobulin if it is a tetanus-prone wound (see above). Arrange further doses of tetanus vaccine as needed to complete the recommended five-dose schedule.
Clarification / Additional information
  • A total of five doses of tetanus vaccine, administered at the appropriate intervals, is considered to give lifelong immunity.
  • Vaccinate the person with a combined tetanus vaccine e.g. tetanus/diphtheria/inactivated polio vaccine, as tetanus vaccine is only available in a combined preparation.
Basis for recommendation
  • These recommendations are based on expert opinion from the Department of Health [DH, 2006a].

© NHS Institute for Innovation and Improvement