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- Scenario: Uncomplicated infection: covers the management of women presenting with an uncomplicated isolated episode of vulvovaginal candidiasis, and how to manage treatment failure. Uncomplicated vulvovaginal candidiasis is defined as:
- Sporadic or infrequent, and
- Mild to moderate, and
- Likely to be due to Candida albicans, and
- NOT associated with risk factors such as pregnancy, poorly controlled diabetes, compromised immunity, and debilitation.
- Scenario: Severe infection: covers the management of women presenting with severe vulvovaginal candidiasis (i.e. with extensive vulvar erythema, oedema, excoriation, and fissure formation), and how to manage treatment failure.
- Scenario: Recurrent infection: covers the management of women suffering from recurrent vulvovaginal candidiasis (i.e. four or more episodes in a year).
- Scenario: During pregnancy: covers the management of women who are pregnant and have vulvovaginal candidiasis, and how to manage treatment failure.
- Scenario: Diabetes or immunocompromised: covers the management of vulvovaginal candidiasis in women who have poorly controlled diabetes mellitus, or who are immunocompromised.
Scenario: Uncomplicated infection
Definition
- Uncomplicated vulvovaginal candidiasis is a symptomatic inflammation of the vagina and/or vulva caused by a superficial fungal infection, usually a Candida species. Such infections are:
- Sporadic or infrequent, and
- Mild-to-moderate, and
- Likely to be due to Candida albicans, and
- In women who are not pregnant, diabetic, immunocompromised, or debilitated.
How should I treat uncomplicated vulvovaginal candidiasis?
- Prescribe (or recommend over-the-counter purchase of) a short course (1–3 days) of an intravaginal antifungal (e.g. clotrimazole, econazole, or miconazole) or oral antifungal (e.g. fluconazole or itraconazole).
- Choice of route and formulation depends upon a number of factors, including the woman's preference.
- For girls aged between 12 and 16 years, oral antifungals (itraconazole or fluconazole) are generally preferred over intravaginal treatments. However, intravaginal antifungals may be considered if the girl is sexually active, if she uses tampons, or if there is no other alternative.
- For vulval symptoms, consider using a topical imidazole cream (e.g. clotrimazole, or econazole) in addition to the oral or intravaginal antifungal.
- Advise the woman to return if symptoms have not resolved within 7–14 days.
In depth
How should I manage treatment failure in uncomplicated vulvovaginal candidiasis?
- Check that treatments have been used as recommended.
- Topical azole therapies can cause vulvovaginal irritation, so consider this if symptoms persist or worsen.
- Consider alternative diagnoses — wrong diagnosis is a common cause for treatment failure.
- Reassess for predisposing risk factors, and remove or control as far as possible.
- Send a vaginal specimen for microscopy and culture.
- Treat:
- If non-compliance has been a problem with an intravaginal imidazole, prescribe a short course of an oral antifungal (e.g. fluconazole or itraconazole).
- If symptoms are improving, consider treating with a longer course of an oral (e.g. itraconazole or fluconazole) or an intravaginal (e.g. clotrimazole, econazole, or miconazole) antifungal.
- For girls aged between 12 and 16 years oral antifungals (itraconazole or fluconazole) are generally preferred over intravaginal treatments. However, intravaginal antifungals may be considered if the girl is sexually active, if she uses tampons, or if there is no other alternative.
- For vulval symptoms, consider prescribing a topical imidazole (e.g. clotrimazole, or econazole) cream in addition to an oral or intravaginal antifungal.
- Refer, or seek specialist advice, if:
- Symptoms are not improving and treatment failure is unexplained.
- Treatment fails again.
- If diagnosis is unclear.
In depth
What general advice can I give about self-management of the current infection?
- Avoid local irritants (such as soaps and shower gels) and tight-fitting synthetic clothes.
- Probiotics (e.g. live yoghurts) may be used orally or topically. Although there is no evidence that they are effective, there is no evidence of (or concern about) adverse effects.
In depth
When should I treat the sexual partner of a woman with vulvovaginal candidiasis?
- Treat the sexual partner only if they are symptomatic.
In depth
Prescriptions
1st line intravaginal antifungals (1-3 days)
Age from 16 years onwards
Clotrimazole pessaries 200mg at night x3 nights
Clotrimazole 200mg pessaries
Insert one pessary into the vagina each night for 3 nights.
Supply 3 Pessary.
Clotrimazole 500mg pessary x1
Clotrimazole 500mg pessaries
Insert one pessary into the vagina at night.
Supply 1 Pessary.
Clotrimazole 10% vaginal cream x1 night
Clotrimazole 10% vaginal cream
Insert one 5g applicatorful into the vagina at night as a single dose.
Supply 5 grams.
Econazole 150mg pessaries x3 nights
Ecostatin 150mg pessaries
Insert one pessary into the vagina each night for 3 nights.
Supply 3 Pessary.
Econazole 150mg pessary x3 nights
Gyno-Pevaryl 150mg vaginal pessaries
Insert one pessary into the vagina each night for 3 nights.
Supply 3 pessary.
Econazole 150mg pessary x1 night.
Gyno-Pevaryl 1 vaginal pessaries 150mg
Insert one pessary into the vagina at night.
Supply 1 pessary.
Miconazole 1.2g vaginal ovule x1 night
Miconazole 1200mg vaginal capsules
Insert one ovule into the vagina at night.
Supply 1 Ovule.
1st line intravaginal combipacks (1-3 days)
Age from 16 years onwards
Econazole 150mg pessaries (x3 nights) + 1% cream
Ecostatin Twin Pack
Insert one pessary high into the vagina each night for 3 nights, and apply cream to the outer affected area twice a day for 3 days.
Supply 1 Twin pack.
Clotrimazole 500mg pessary (x1 night) + 2% cream
Clotrimazole 500mg pessary and Clotrimazole 2% cream
Insert one pessary into the vagina at night for 1 night, and apply cream to the outer affected area 2 to 3 times a day for up to 7 days.
Supply 1 combi-pack.
1st line oral therapy (1 day)
Age from 12 years to 15 years 11 months
Fluconazole 150mg capsules
Take the capsule as a single dose.
Supply 1 capsule.
Age from 12 years onwards
Itraconazole 100mg capsules
Take two capsules twice a day for 1 day only.
Supply 4 capsules.
Age from 16 years onwards
Fluconazole 150mg capsules
Take the capsule as a single dose.
Supply 1 capsule.
Treatment failure-intravaginal antifungals (6-14 days)
Age from 16 years onwards
Clotrimazole 100mg pessaries x6 nights
Clotrimazole 100mg pessaries
Insert one pessary into the vagina each night for 6 nights.
Supply 6 pessary.
Clotrimazole 100mg pessaries x12 nights
Clotrimazole 100mg pessaries
Insert one pessary into the vagina each night for 12 nights.
Supply 12 pessary.
Clotrimazole 200mg pessaries x6 nights
Clotrimazole 200mg pessaries
Insert one pessary into the vagina each night for 6 nights.
Supply 6 pessaries.
Econazole 150mg pessaries x6 nights
Econazole 150mg pessaries
Insert one pessary into the vagina each night for 6 nights.
Supply 6 pessary.
Treatment failure-intravaginal combipacks (7-14 days)
Age from 12 years onwards
Miconazole 2% vaginal cream x 7nights
Miconazole 2% cream
Insert one 5g applicatorful into the vagina twice a day for 7 days, and apply cream to the outer affected area twice a day for 7 days.
Supply 1 combi pack.
Age from 16 years onwards
Miconazole 2% vaginal cream x14 nights
Miconazole 2% cream
Insert one 5g applicatorful into the vagina each night for 14 nights, and apply cream to the outer affected area each night for 14 nights.
Supply 1 combi pack.
Treatment failure-oral therapy (7 days)
Age from 12 years onwards
Itraconazole 200mg x7 days
Itraconazole 100mg capsules
Take two capsules once a day for 7 days.
Supply 14 capsules.
Age from 16 years onwards
Fluconazole capsules: 100mg once a day for 7 days
Fluconazole 50mg capsules
Take two capsules once a day for 7 days.
Supply 14 capsules.
External cream (add on treatment)
Age from 12 years onwards
Clotrimazole cream 2% apply 2 to 3 times a day
Clotrimazole 2% cream
Apply to the affected area 2 to 3 times a day for up to 7 days
Supply 20 grams.
Econazole 1% cream apply twice a day
Econazole 1% cream
Apply to the affected area twice a day for up to 7 days.
Supply 30 grams.
Scenario: Severe infection
Definition
- In severe vulvovaginal candidiasis there is:
- Extensive vulvar erythema
- Oedema
- Excoriation
- Fissure formation
How should I treat severe vulvovaginal candidiasis?
- Send a vaginal specimen for microscopy and culture.
- Treat:
- Treat with either two doses of oral fluconazole (150 mg) 3 days apart, or, if oral treatment is contraindicated, use two clotrimazole pessaries (500 mg) 3 days apart.
- Choice of antifungal will depend upon a number of factors, including the woman's preference.
- For girls aged between 12 and 16 years, an oral antifungal (fluconazole) is generally preferred over intravaginal treatments. However, intravaginal antifungals may be considered if the girl is sexually active, if she uses tampons, or if there is no other alternative.
- For vulval symptoms, consider using a topical antifungal cream (e.g. clotrimazole or econazole) in addition to an oral or intravaginal antifungal.
- Advise the woman to return if symptoms have not resolved within 7–14 days.
In depth
How should I manage treatment failure of severe vulvovaginal candidiasis?
- Consider alternative diagnoses — a wrong diagnosis is a common cause for treatment failure.
- Reassess for predisposing risk factors, and remove or control as far as possible.
- Send a vaginal specimen for culture.
- Manage:
- If non-compliance has been a problem with an intravaginal imidazole, prescribe a course of oral fluconazole 150 mg (2 doses 3 days apart).
- If non-compliance has been a problem with oral fluconazole, prescribe clotrimazole pessaries 500 mg (2 doses 3 days apart).
- For vulval symptoms, consider prescribing a topical imidazole cream in addition to an oral or intravaginal antifungal.
- For girls aged between 12 and 16 years, offer oral fluconazole.
- In this age group oral antifungals are generally preferred over intravaginal treatments. However, intravaginal antifungals may be considered if the girl is sexually active, if she uses tampons, or if there is no other alternative.
- Refer, or seek specialist advice, if:
- Symptoms have not improved and treatment failure is unexplained.
- Treatment fails again.
In depth
What general advice can I give about self-management of the current infection?
- Avoid local irritants (such as soaps and shower gels) and tight-fitting synthetic clothes.
- Probiotics (e.g. live yoghurts) may be used orally or topically. Although there is no evidence that they are effective, there is no evidence of (or concern about) adverse effects.
In depth
When should I treat the sexual partner of a woman with vulvovaginal candidiasis?
- Treat the sexual partner only if they are symptomatic.
In depth
Prescriptions
Clotrimazole/severe candida
Age from 16 years onwards
Clotrimazole 500mg pessary x2 doses
Clotrimazole 500mg pessaries
Insert one pessary into the vagina at night and repeat after 3 days
Supply 2 Pessary.
Oral fluconazole/severe candida
Age from 12 years onwards
Fluconazole 150mg x2 doses
Fluconazole 150mg capsules
Take one capsule, then repeat after 72 hours.
Supply 2 capsule.
External cream (add on treatment)
Age from 12 years onwards
Clotrimazole cream 2% apply 2 to 3 times a day
Clotrimazole 2% cream
Apply to the affected area 2 to 3 times a day for up to 7 days
Supply 20 grams.
Econazole 1% cream apply twice a day
Econazole 1% cream
Apply to the affected area twice a day for up to 7 days.
Supply 30 grams.
Scenario: Recurrent infection
Definition
- Recurrent vulvovaginal candidiasis is defined (for research purposes) as the occurrence of four or more episodes within a year.
- In decisions about investigation, treatment, and referral, clinical judgement should be used when classifying a woman as having recurrent vulvovaginal candidiasis.
How do I manage recurrent vulvovaginal candidiasis infection?
- Eliminate or control predisposing risk factors as far as is practical.
- Take a high vaginal swab for microscopy and speciated culture to confirm the diagnosis, and identify the presence of:
- Non-albicans Candida species.
- A mixed infection such as candidiasis with bacterial vaginosis or trichomoniasis (up to 10% of infections are mixed). See the CKS topics on Bacterial vaginosis and Trichomoniasis.
- Consider alternative diagnoses if a woman has recurrent or persistent symptoms.
- Treat the presenting episode with a longer induction course. Two options are:
- Fluconazole 150 mg every 72 hours for 3 doses, or
- Topical imidazole therapy for 10–14 days according to symptomatic response.
- Seek specialist advice for the treatment of recurrent non-albicans Candida species infections.
- For vulval symptoms, consider using a topical antifungal cream, in addition to the oral or intravaginal antifungal.
- For future management offer:
- Either 'treatment as required' with a prescription to be used if symptoms recur,
- Or a 'maintenance regimen' with 6 months of an oral or intravaginal antifungal (off-licence use).
- Follow up after the maintenance period has been completed.
- If, after completing a course of maintenance therapy, vulvovaginal candidiasis recurs infrequently, treat each episode independently. If recurrent disease is troublesome, repeat the induction and maintenance regimens.
- Choice of antifungal regimen:
- The choice of antifungal and route (oral or intravaginal) will depend upon a number of factors. Most women prefer oral products to intravaginal creams or pessaries, especially for longer-term use.
- For girls between 12 and 16 years old, offer oral fluconazole or itraconazole (off license uses) for induction, maintenance or 'treatment as required'. However, intravaginal antifungals may be considered if the girl is sexually active, if tampons are being used, or if there is no other alternative.
In depth
When should I treat the sexual partner of a woman with vulvovaginal candidiasis?
- Treat the sexual partner only if they are symptomatic.
In depth
What advice can I give about self-management of future episodes?
- If a similar episode occurs in the future, oral and topical treatments can be bought at pharmacies, and no prescription will be required.
- Over-the-counter products should not be used over the longer term without medical advice.
- To return for assessment by a healthcare professional if the woman:
- Is under 16 or over 60 years of age.
- Is pregnant.
- Has symptoms that are not entirely consistent with a previous episode.
- Has had two episodes in 6 months, and has not consulted a healthcare professional about the condition for more than a year.
- Has had a previous sexually transmitted infection (herself or her partner).
- Has had a previous adverse reaction to an antifungal drug, or antifungal drugs have proved ineffective.
In depth
Prescriptions
Induction therapy
Age from 12 years onwards
Fluconazole 150mg x3 doses
Fluconazole 150mg capsules
Take one capsule every 3 days for 9 days
Supply 3 capsules.
Itraconazole 200mg x7 days
Itraconazole 100mg capsules
Take two capsules once a day for 7 days.
Supply 14 capsules.
Age from 16 years onwards
Clotrimazole 200mg pessaries x6 nights
Clotrimazole 200mg pessaries
Insert one pessary into the vagina each night for 6 nights.
Supply 6 pessaries.
Clotrimazole 200mg pessaries x12 nights
Clotrimazole 200mg pessaries
Insert one pessary into the vagina each night for 12 nights.
Supply 12 pessaries.
Maintenance therapy (2-month supply)
Age from 12 years onwards
Fluconazole 150mg x2 doses
Fluconazole 150mg capsules
Take one capsule on the same day once a week
Supply 8 capsule.
Age from 16 years onwards
Clotrimazole 500mg pessary x1
Clotrimazole 500mg pessaries
Insert one pessary into the vagina at night once a WEEK.
Supply 8 pessary.
Itraconazole 400mg once a month
Itraconazole 100mg capsules
Take two capsules twice in one day once a MONTH.
Supply 8 capsules.
As required therapy (1-3 days) intravaginal
Age from 16 years onwards
Clotrimazole pessaries 200mg at night x3 nights
Clotrimazole 200mg pessaries
Insert one pessary into the vagina each night for 3 nights.
Supply 3 Pessary.
Clotrimazole 500mg pessary x1
Clotrimazole 500mg pessaries
Insert one pessary into the vagina at night.
Supply 1 Pessary.
Clotrimazole 10% vaginal cream x1 night
Clotrimazole 10% vaginal cream
Insert one 5g applicatorful into the vagina at night as a single dose.
Supply 5 grams.
Econazole 150mg pessaries x3 nights
Ecostatin 150mg pessaries
Insert one pessary into the vagina each night for 3 nights.
Supply 3 Pessary.
Econazole 150mg pessary x3 nights
Gyno-Pevaryl 150mg vaginal pessaries
Insert one pessary into the vagina each night for 3 nights.
Supply 3 pessary.
Econazole 150mg pessary x1 night.
Gyno-Pevaryl 1 vaginal pessaries 150mg
Insert one pessary into the vagina at night.
Supply 1 pessary.
Miconazole 1.2g vaginal ovule x1 night
Miconazole 1200mg vaginal capsules
Insert one ovule into the vagina at night.
Supply 1 Ovule.
As required oral therapy (1 day)
Age from 12 years to 15 years 11 months
Fluconazole 150mg capsules
Take the capsule as a single dose.
Supply 1 capsule.
Age from 12 years onwards
Itraconazole 100mg capsules
Take two capsules twice a day for 1 day only.
Supply 4 capsules.
Age from 16 years onwards
Fluconazole 150mg capsules
Take the capsule as a single dose.
Supply 1 capsule.
External cream (add on treatment)
Age from 12 years onwards
Clotrimazole cream 2% apply 2 to 3 times a day
Clotrimazole 2% cream
Apply to the affected area 2 to 3 times a day for up to 7 days
Supply 20 grams.
Econazole 1% cream apply twice a day
Econazole 1% cream
Apply to the affected area twice a day for up to 7 days.
Supply 30 grams.
Scenario: Vulvovaginal candidiasis during pregnancy
Definition
- Vulvovaginal candidiasis is a symptomatic inflammation of the vagina and/or vulva caused by a superficial fungal infection, usually a Candida species.
- Vulvovaginal candidiasis during pregnancy is considered to be complicated vulvovaginal candidiasis, because it requires more intensive treatment than uncomplicated vulvovaginal candidiasis.
How should I manage vulvovaginal candidiasis in women who are pregnant?
- Treat with intravaginal clotrimazole or miconazole for at least 7 days.
- Advise the woman that care should be taken when using an applicator during pregnancy to avoid physical damage to the cervix. Some women prefer to insert pessaries by hand when pregnant.
- For vulval symptoms consider using a topical imidazole cream (e.g. clotrimazole), in addition to an intravaginal imidazole.
- Do not use oral antifungals such as fluconazole and itraconazole.
- Advise the woman to return if symptoms have not resolved within 7–14 days.
In depth
How should I manage treatment failure in women who are pregnant?
- Check that treatments have been used as recommended.
- Consider alternative diagnoses.
- Reassess for other predisposing risk factors, and remove or control as far as possible.
- Send a vaginal specimen for culture.
- Manage:
- Give general advice about avoiding local irritants (such as soaps and shower gels) and tight-fitting synthetic clothes.
- If symptoms are improving, consider giving a second course of an intravaginal antifungal (clotrimazole or miconazole).
- Do not use oral antifungals such as fluconazole or ketoconazole.
- For vulval symptoms, consider prescribing a topical imidazole cream (e.g. clotrimazole) in addition to an intravaginal imidazole.
- Refer, or seek specialist advice if:
- Compliance has been a problem because of adverse effects.
- Symptoms are not improving and treatment failure is unexplained.
In depth
When should I treat the sexual partner of a woman with vulvovaginal candidiasis?
- Treat the sexual partner only if they are symptomatic.
In depth
Prescriptions
Intravaginal antifungals (7-14 days)/pregnancy
Age from 16 years onwards
Clotrimazole 100mg pessaries x12 nights
Clotrimazole 100mg pessaries
Insert one pessary into the vagina each night for 12 nights.
Supply 12 pessary.
Intravaginal antifungals (7-14 days)/combipacks/pregnancy
Age from 12 years onwards
Miconazole 2% vaginal cream x 7nights
Miconazole 2% cream
Insert one 5g applicatorful into the vagina twice a day for 7 days, and apply cream to the outer affected area twice a day for 7 days.
Supply 1 combi pack.
Age from 16 years onwards
Miconazole 2% vaginal cream x14 nights
Miconazole 2% cream
Insert one 5g applicatorful into the vagina each night for 14 nights, and apply cream to the outer affected area each night for 14 nights.
Supply 1 combi pack.
External cream (add-on treatment)
Age from 12 years onwards
Clotrimazole cream 2% apply 2 to 3 times a day
Clotrimazole 2% cream
Apply to the affected area 2 to 3 times a day for up to 7 days
Supply 20 grams.
Scenario: Vulvovaginal candidiasis and poorly controlled diabetes or immunocompromised
How should I manage vulvovaginal candidiasis in women who have poorly controlled diabetes or who are immunocompromised?
- For women who have poorly controlled diabetes or who are are immunocompromised (e.g. receiving immunosuppressant drugs such as long-term corticosteroids, or with HIV/AIDS):
- Correct modifiable conditions (e.g. uncontrolled diabetes).
- Give general advice to avoid local irritants (such as soaps and shower gels) and tight-fitting synthetic clothes.
- Treat with long courses (7 days) of oral antifungals (e.g. fluconazole or itraconazole) or intravaginal antifungals (e.g. clotrimazole, econazole, or miconazole) for 6–14 days.
- Choice of treatment will depend upon a number of factors, including patient preference.
- For vulval symptoms, consider using a topical imidazole cream (e.g. clotrimazole, or econazole), in addition to an oral or intravaginal antifungal.
- For girls aged between 12 and 16 years, offer a 7 day course of an oral antifungal (fluconazole or itraconazole). However, an intravaginal antifungal may be considered if the girl is sexually active, if tampons are being used, or if there is no other alternative.
- Advise the woman to return if:
- Symptoms have not resolved within 7–14 days.
- She becomes systemically unwell.
In depth
How should I manage treatment failure in women who have poorly controlled diabetes or who are immunocompromised?
- Check that treatments have been used as recommended.
- Review the clinical evidence on which vulvovaginal candidiasis was diagnosed.
- Consider alternative diagnoses.
- Reassess for other predisposing risk factors, and remove or control as far as possible.
- Send a vaginal specimen for culture.
- Manage:
- Give general advice about avoiding local irritants (such as soaps and shower gels) and tight-fitting synthetic clothes.
- If compliance has been a problem with an intravaginal imidazole, prescribe a course (7 days) of an oral antifungal (e.g. fluconazole or itraconazole).
- If compliance has been a problem with oral antifungal, then prescribe a course (6–14 days) of intravaginal imidazoles (e.g. clotrimazole, econazole, or miconazole).
- For girls between 12 and 16 years old, offer a 7 day course of oral antifungal (fluconazole or itraconazole). However, an intravaginal antifungal may be considered if the girl is sexually active, if tampons are being used, or if there is no other alternative.
- Refer, or seek specialist advice, if:
- Treatment failure is unexplained.
- Treatment fails again.
- The woman develops systemic symptoms.
In depth
Prescriptions
Intravaginal antifungals (6-14 days)/diabetes
Age from 16 years onwards
Clotrimazole 100mg pessaries x6 nights
Clotrimazole 100mg pessaries
Insert one pessary into the vagina each night for 6 nights.
Supply 6 pessary.
Clotrimazole 200mg pessaries x6 nights
Clotrimazole 200mg pessaries
Insert one pessary into the vagina each night for 6 nights.
Supply 6 pessaries.
Clotrimazole 100mg pessaries x12 nights
Clotrimazole 100mg pessaries
Insert one pessary into the vagina each night for 12 nights.
Supply 12 pessary.
Econazole 150mg pessaries x6 nights
Econazole 150mg pessaries
Insert one pessary into the vagina each night for 6 nights.
Supply 6 pessary.
Intravaginal antifungals (7-14 days)/combipacks/diabetes
Age from 12 years onwards
Miconazole 2% vaginal cream x 7nights
Miconazole 2% cream
Insert one 5g applicatorful into the vagina twice a day for 7 days, and apply cream to the outer affected area twice a day for 7 days.
Supply 1 combi pack.
Age from 16 years onwards
Miconazole 2% vaginal cream x14 nights
Miconazole 2% cream
Insert one 5g applicatorful into the vagina each night for 14 nights, and apply cream to the outer affected area each night for 14 nights.
Supply 1 combi pack.
Oral antifungals (7 days)/diabetes
Age from 12 years onwards
Fluconazole 100mg x7 days
Fluconazole 50mg capsules
Take two capsules once a day for 7 days.
Supply 14 capsules.
Itraconazole 200mg x7 days
Itraconazole 100mg capsules
Take two capsules once a day for 7 days.
Supply 14 capsules.
External cream (add on treatment)
Age from 12 years onwards
Clotrimazole cream 2% apply 2 to 3 times a day
Clotrimazole 2% cream
Apply to the affected area 2 to 3 times a day for up to 7 days
Supply 20 grams.
Econazole 1% cream apply twice a day
Econazole 1% cream
Apply to the affected area twice a day for up to 7 days.
Supply 30 grams.