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CKS is no longer commissioned by the National Institute for Health and Clinical Excellence (NICE). NICE remains committed to providing a replacement service for CKS and is currently reviewing its options. In the meantime, although CKS content is now not being maintained, it still remains relevant and will continue to be made available. CKS content was generated under a programme of topic creation and update. To check if the topic you are viewing is current or out of date, please refer to the topic publication details by clicking on the 'How up-to-date is this topic?' link in the left hand menu on individual topic pages.

Children's tumours - suspected - Management
Leukaemia (all ages)

  • Leukaemia usually presents with a relatively short history of weeks rather than months. The presence of one or more of the following symptoms and signs requires investigation with full blood count and blood film. If the blood film or full blood count indicates leukaemia then an urgent referral should be made (C [DS]).
    • Pallor
    • Fatigue
    • Unexplained irritability
    • Unexplained fever
    • Persistent or recurrent upper respiratory tract infections
    • Generalised lymphadenopathy
    • Persistent or unexplained bone pain
    • Unexplained bruising
  • The presence of either of the following signs in a child or young person requires immediate referral: (C)
    • Unexplained petechiae
    • Hepatosplenomegaly

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