Important aspects of prescribing information relevant to primary healthcare are covered in this section specifically for the drugs recommended in this CKS topic. For further information on contraindications, cautions, drug interactions, and adverse effects, see the electronic Medicines Compendium (eMC) (http://emc.medicines.org.uk), or the British National Formulary (BNF) (www.bnf.org).

• Hypoallergenic infant milk formulas are made from hydrolysed cow's milk protein (casein or whey) or from other sources of protein such as soya.
• Hypoallergenic infant milk formulas are also low in, or free of, lactose.
• The following hypoallergenic infant milk formulas are available on the NHS:
• Casein hydrolysate — Nutramigen 1 LIPIL ^® and Pregestimil LIPIL ^®.
• Whey hydrolysate — Pepti-Junior^®.
• The prescription must be endorsed ACBS.
• The Chief Medical Officer recommends that soya infant milk formulas should not be the first choice of treatment for cow's milk sensitivity or lactose intolerance [CMO, 2004]. This is because they have a high phytoestrogen content, and this may pose a risk to future fertility and sexual development [Committee on Toxicity, 2003].

• Breastfeeding: express about a tablespoon of foremilk into a sterile container; add four drops of lactase; breastfeed as usual, and then give the foremilk with the lactase at the end of the feed using a sterilized plastic teaspoon.
• Bottle feeding: add four drops of lactase to the feed; shake gently; refrigerate for about half an hour before warming and feeding.

[Kanabar et al, 2001; Crosscare, 2004]

• Simeticone is well tolerated: there are no contraindications or adverse effects listed in the manufacturer's summary of product characteristics [ABPI Medicines Compendium, 2006].