Print Print
CKS is no longer commissioned by the National Institute for Health and Clinical Excellence (NICE). NICE remains committed to providing a replacement service for CKS and is currently reviewing its options. In the meantime, although CKS content is now not being maintained, it still remains relevant and will continue to be made available. CKS content was generated under a programme of topic creation and update. To check if the topic you are viewing is current or out of date, please refer to the topic publication details by clicking on the 'How up-to-date is this topic?' link in the left hand menu on individual topic pages.

Colic - infantile - Management
View full scenario

Definition

Infantile colic is defined as repeated episodes of excessive and inconsolable crying in an infant that otherwise appears to be healthy and thriving.

What advice should I give to the parents?

  • Reassure the parents that their baby is well, they are not doing something wrong, the baby is not rejecting them, and that colic is common and is a phase that will pass within a few months.
  • Holding the baby through the crying episode may be helpful. However, if there are times when the crying feels intolerable, it is best to put the baby down somewhere safe (e.g. their cot) and take a few minutes' 'time out'.
  • Other strategies that may help to soothe a crying infant include:
    • Gentle motion (e.g. pushing the pram or a ride in the car).
    • 'White noise' (e.g. vacuum cleaner, hairdryer, running water).
    • Bathing in a warm bath.
  • Encourage parents to look after their own well-being:
    • Ask family and friends for support — parents need to be able to take a break.
    • Rest when the baby is asleep.
    • Meet other parents with babies of the same age.
  • CRY-SIS is a support group for families with excessively crying, sleepless, and demanding children. Their helpline is available every day from 9 a.m. to 10 p.m. Tel: 08451 228 669. The CRY-SIS website (www.cry-sis.org.uk) also contains useful information.

In depth

When should treatment for infantile colic be considered, and with what?

  • The most useful intervention is support for parents and reassurance that infantile colic will resolve.
  • Only consider trying medical treatments if parents feel unable to cope despite advice and reassurance. The options for medical treatments are:
    • A 1-week trial of simeticone drops (breastfed or bottle-fed).
    • A 1-week trial of diet modification to exclude cow's milk protein:
      • Breastfed babies: dairy-free diet for the mother.
      • Bottle-fed babies: hypoallergenic formula.
    • A 1-week trial of lactase drops (breastfed or bottle-fed).
  • Only continue treatment if there is a response (i.e. the duration of crying shortens).
    • If there is no response to one medical treatment, consider trying another.
    • Breastfeeding mothers should take a calcium supplement if they are going to remain on a dairy-free diet long term.
  • If the baby does respond to lactase or hypoallergenic diet, reassure the parents that this does not necessarily mean that they are lactose intolerant or allergic to cow's milk. These are rare conditions that affect very few babies with infantile colic.

In depth

When should I consider stopping treatment?

  • If there is no response to the trial of treatment stop it.
  • If there is a response to treatment: after the age of 3 months (and by 6 months of age at the latest), wean off treatment over a period of about 1 week.

In depth

When should I refer a baby with infantile colic?

  • Seek advice from a paediatrician if:
    • The parents are not coping despite advice, reassurance, and primary care interventions.
    • There is diagnostic doubt (e.g. the baby is not thriving; crying is not starting to get better or is getting worse after 4 months of age; significant gastro-oesophageal reflux is suspected).
    • Unable to wean off treatment by the age of 6 months.

In depth

Prescriptions

1st line: advice and reassurance

Age under 6 months
Advice only: infantile colic
Age: under 6 months
Licensed use: no
Patient information: Although your baby has periods of inconsolable crying (infantile colic), your baby IS well and thriving and the crying is not caused by anything that you are doing wrong. Colic is very common, and will pass within a few months.

2nd line: 1-week trial of simeticone drops

Age under 6 months
Breastfed or bottle fed: Simeticone drops
Simeticone 40mg/ml oral suspension sugar free
Give one dropperful (0.5ml) before each feed. Increase to two dropperfuls (1ml) if required.
Supply 50 ml.
Age: under 6 months
NHS cost: £2.14
OTC cost: £3.77
Licensed use: yes

2nd line: 1-week trial of hypoallergenic diet

Age under 6 months
Breastfed: dairy-free diet for the mother
Age: under 6 months
Licensed use: no
Patient information: Some babies cry less if cows milk is stopped, but this does not occur in most babies. However, if colic is severe, it may be worth Mum trying without cow's milk for one week. This means not having any dairy products, as part of the cow's milk can get into breast milk. If there is an improvement, continue without cow's milk until the baby is three months old. Colic is not a 'true' allergy though, and after the colic has settled the baby will be able to take cow's milk again. If there is no improvement after one week, there is no point in continuing without cows milk, and you should resume normal feeds.
Bottle-fed: Pepti-Junior formula (whey based) (Endorse ACBS)
Pepti-Junior powder
Use as baby milk. Follow directions on the side of the container.
Supply 450 grams.
Age: under 6 months
NHS cost: £8.91
OTC cost: £13.00
Licensed use: no - misc item available on the NHS
Patient information: Colic is not a 'true' allergy and, after the colic has settled the baby will be able to take ordinary formula again. If there is no improvement after one week, there is no point in continuing with Pepti-Junior, and you should resume normal feeds.
Bottle-fed: Nutramigen 1 LIPIL formula (casein based) (Endorse ACBS)
Generic Nutramigen 1 LIPIL powder
Use as baby milk. Follow directions on the side of the container.
Supply 425 grams.
Age: under 6 months
NHS cost: £7.81
OTC cost: £11.51
Licensed use: no - misc item available on the NHS
Patient information: Colic is not a 'true' allergy and, after the colic has settled the baby will be able to take ordinary formula again. If there is no improvement after one week, there is no point in continuing with Nutramigen 1, and you should resume normal feeds.
Bottle-fed: Pregestimil LIPIL formula (casein based) (Endorse ACBS)
Generic Pregestimil LIPIL powder
Use as baby milk. Follow directions on the side of the container.
Supply 400 grams.
Age: under 6 months
NHS cost: £8.91
OTC cost: £13.00
Licensed use: no - misc item available on the NHS
Patient information: Colic is not a 'true' allergy and, after the colic has settled the baby will be able to take ordinary formula again. If there is no improvement after one week, there is no point in continuing with Pregestimil, and you should resume normal feeds.

2nd-line: 1-week trial of lactase

Age under 6 months
Breastfed: lactase drops
Colief 50,000units/g infant drops
Express about a tablespoon of foremilk into a sterile container and add four drops of lactase. Breastfeed as usual, and then give the foremilk with the lactase at the end of the feed using a sterilized plastic teaspoon.
Supply 7 ml.
Age: under 6 months
NHS cost: £7.00
OTC cost: £9.00
Licensed use: no - misc item available on the NHS
Patient information: Colic is not a 'true' allergy, and after the colic has settled the baby will be able to digest lactose again. If there is no improvement after one week, there is no point in continuing with Colief drops, and you should resume normal feeds.
Bottle fed: lactase drops
Colief 50,000units/g infant drops
Warm the feed and add four drops of lactase, wait for half an hour, and occasionally shake gently before feeding the baby.
Supply 7 ml.
Age: under 6 months
NHS cost: £7.00
OTC cost: £9.00
Licensed use: no - misc item available on the NHS
Patient information: Colic is not a 'true' allergy, and after the colic has settled the baby will be able to digest lactose again. If there is no improvement after one week, there is no point in continuing with Colief drops, and you should resume normal feeds.

© NHS Institute for Innovation and Improvement