Print Print
CKS is no longer commissioned by the National Institute for Health and Clinical Excellence (NICE). NICE remains committed to providing a replacement service for CKS and is currently reviewing its options. In the meantime, although CKS content is now not being maintained, it still remains relevant and will continue to be made available. CKS content was generated under a programme of topic creation and update. To check if the topic you are viewing is current or out of date, please refer to the topic publication details by clicking on the 'How up-to-date is this topic?' link in the left hand menu on individual topic pages.

Contraception - Management
View all detailed answers

How can I help a woman choose which method of contraception is most suitable for her?

Clarification / Additional information

Ethical and legal issues when providing contraception to young women, and women with learning difficulties

What ethical and legal issues do I need to consider when providing contraception to girls under 16 years of age?

When providing contraception to young people, take account of:

  • Communication of the level of confidentiality [FFPRHC, 2004b]:
    • Inform young people seeking contraceptive advice and services that confidentiality is to be expected from all members of the healthcare team, but that other professionals, such as teachers and youth workers, may not have the same duty of confidentiality.
    • Inform a young person under 16 years of age in advance that confidentiality might be broken if maltreatment, exploitation, or coercion is suspected:
      • If information is to be shared or confidentiality breached, the young person will be informed and her consent sought.
      • Consent is not essential if the disclosure is justified.
      • The timing of any reporting or breach of confidentiality will be carefully considered.
  • Legal and ethical issues:
    • The legal age of consent to sexual activity is 16 years in Scotland, England, and Wales, and 17 years in Northern Ireland. Sexual activity under the age of consent is an offence even if consensual and is considered more serious (statutory rape) when the person is less than 13 years of age [FFPRHC, 2004b].
    • In England and Wales, it is lawful to provide contraceptive advice and treatment to girls under the age of 16 years without parental consent, provided that the healthcare professional is satisfied that the Fraser guidelines have been met [Teenage Pregnancy Unit, 2001; FFPRHC, 2004b; Wheeler, 2006].
    • The Fraser guidelines are a set of criteria which must be fulfilled when contraceptive services are provided to people less than 16 years of age without their parent's knowledge or permission:
      • The young person understands the advice given to her by the health professional.
      • The young person cannot be persuaded to inform her parents, or to allow the health professional to inform them.
      • It is likely that the young person will continue to have sexual intercourse, with or without the use of contraception.
      • The young person's physical or mental health may suffer as a result of withholding contraceptive advice or treatment.
      • It is in the best interests of the young person for the clinician to provide contraceptive advice or treatment, or both, without parental consent.
    • In Scotland, similar criteria apply under The Age of Legal Capacity Act 1991. The Act appears to assign more legal rights to children under 16 years of age, in that parental responsibility cannot authorize procedures that a competent child has refused [Sterrick, 2006; Wheeler, 2006].
    • Consider child protection issues, including the possibility of exploitation or coercion, when providing contraception to girls younger than 16 years of age [National Collaborating Centre for Women's and Children's Health, 2005].
  • Competence to consent to treatment [FFPRHC, 2004b]:
    • Assess a young person's competence to consent to treatment by her ability:
      • To understand the information provided and
      • To weigh up the risks and benefits and
      • To express her own wishes.
    • If a young person is determined to be competent, this should be documented in the case notes.
  • Documentation [FFPRHC, 2004b]:
    • Document assessments made of vulnerabilities, e.g. Fraser criteria.
Clarification / Additional information
  • The mnemonic UPSIC (UnProtected Sexual InterCourse) can help to remember all these points:
    • Understands
    • Parents
    • Sex/Suffer
    • Interests
    • Confidentiality; Coercion an issue?

[Guillebaud, 2007]

What ethical and legal issues do I need to take account of when providing contraception to people with learning disabilities?

Sexually transmitted infections: assessing risk; advice on safer sex

How should I assess someone's risk for sexually transmitted infection?

  • Take into consideration the local prevalence of sexually transmitted infections, the person's age, and their sexual activity.
  • Consider their risk for having been exposed to sexually transmitted infection, including HIV:
    • Ask about their current circumstances, current and recent sexual partners, age of onset of sexual activity, type of sexual activity and use of alcohol and other substances.
  • Key groups at risk of sexually transmitted infections include:
    • People involved in prostitution.
    • Men who have sex with men.
    • People who have come from or who have visited areas of high HIV prevalence (and have been sexually active there).
  • Behaviours that increase the risk of sexually transmitted infections include:
    • Misuse of alcohol and/or substances ('recreational' drugs), and especially sharing equipment such as needles.
    • Early onset of sexual activity.
    • Sexual activity without protection (e.g. provided by condoms).
    • Frequent change of and/or multiple sexual partners.
Clarification / Additional information
  • Basic rules on sexual history taking [RCGP and BASHH, 2006]:
    • Privacy and the assurance of confidentiality are essential.
    • Many STIs can be asymptomatic, but when symptoms are present (see below), the patient may not link them to an STI, so you may have to raise the subject sensitively.
    • Do not make assumptions about:
      • Sexual orientation (a married man may still have sex with other men).
      • Age (sexual liberation is not exclusive to the young).
      • Anything!
    • Sometimes you will need to ask direct questions when the person does not volunteer information; explain why you need to ask something, but only ask what is relevant.
    • Embarrassment can be infectious; try not to let your own feelings/opinions interfere.
    • Have a non-judgemental attitude.
    • Clarify terms: 'sex' does not always mean peno-vaginal penetration, and many sexually transmitted infections are spread easily from oral or anal sex.
    • Be aware that condoms are often put on after some penetration has already taken place, and condoms also split/come off.
    • Be alert to non-consensual sex and child protection issues.
    • Alcohol and drug use can lead to risk-taking sexual behaviour, and financial difficulties may lead to prostitution.
Basis for recommendation
  • These recommendations are based on guidelines from the Faculty of Sexual and Reproductive Healthcare (FSRH), (formerly the Faculty of Family Planning and Reproductive Healthcare [FFPRHC]), and the National Institute for Health and Clinical Excellence, and information from the fpa (Family Planning Association) [Belfield et al, 2006; FFPRHC, 2006b; RCGP and BASHH, 2006; NICE, 2007a].

What advice should I give about safer sex and avoiding sexually transmitted infections?

Advise that:

  • The risks of unsafe sex include:
    • Unwanted pregnancy
    • Cervical cancer
    • Infertility
    • Sexually transmitted infections (STIs), such as:
      • Chlamydia
      • Genital herpes
      • Genital warts
      • Gonorrhoea
      • Hepatitis A, B, and C
      • HIV
      • Non-specific urethritis
      • Syphilis
      • Trichomonas vaginalis
  • Infections can be passed from one person to another by:
    • Penetrative sex (vaginal, oral, or anal)
    • Non-penetrative sex, intimate skin-to-skin or hair-to-hair contact, and kissing, especially if semen or vaginal fluids come into contact with the genitals, anus, mouth, eyes, or broken skin.
    • Sharing sex toys.
  • People are often not aware that they have a sexually transmitted infection. It is therefore important to practice safe sex even when both partners believe that they are not infected.
  • Tips for safe sex:
    • The safest sex (apart from masturbation alone) is with a regular, 100% faithful partner. Sex with 'anonymous' partners is the riskiest. Sex with a best friend can be a risk if there is no discussion about other/previous partners.
    • Any cut, sore, or open skin lesion on the finger, should be covered (e.g. with waterproof plasters, or by wearing latex gloves) during genital or anal foreplay. Hands should be washed after anal foreplay.
    • A condom (male or female) should be used when having sex with someone who is not a regular, faithful partner, or when the regular, faithful partner has a sexually transmitted infection.
    • A condom should be put on before the penis contacts the partner's genitals, anus, or mouth.
    • When having oral sex, a male or female condom should be used, or a dam used to cover the anus or female genitals.
    • Oral sex and genital sex should be avoided if either partner:
      • Has a sexually transmitted infection.
      • Has sores, cuts, ulcers, blisters, warts, or rashes around the genitals, anus, or mouth.
      • Has any unhealed or inflamed piercings in the mouth or genitals.
    • Oral sex should be avoided if either partner has a throat infection.
    • Where there is a risk of STI, avoid:
      • Giving oral sex to a woman who is menstruating.
      • Brushing or flossing teeth shortly before or after giving someone oral sex (as this can cause the gums to bleed).
    • Semen and vaginal fluid should be kept out of the eyes.
    • Sex toys should be washed and/or covered with a new condom before they are shared.
    • When having penetrative anal sex, the condom should be lubricated with a water-based or silicone lubricant, avoiding oily lubricants and spermicides (as they can weaken the condom enough for it to split). The condom should be changed when moving between anal and vaginal sex. If no spare condom is available, progress should be from the vagina to the anus rather than from the anus to the vagina.
  • Any symptoms that might be caused by a sexually transmitted infection, such as itchiness or swelling around the genitals, or an unusual discharge, should prompt abstinence. The partner should be told, and a GP or sexual health clinic consulted.

Reassure that:

  • People cannot catch, or pass on, sexually transmitted infections by: hugging; sharing baths or towels; swimming pools, toilet seats; or sharing cups, plates, or cutlery. However, genital warts, pubic lice, and scabies can be passed on by intimate contact, including skin-to-skin or hair-to-hair.
  • Except for herpes, people cannot catch, or pass on, sexually transmitted infections by kissing.
  • Warts on the hand cannot be passed to the genitals.

[Belfield et al, 2006]

  • A woman is unlikely to be pregnant if she has no signs or symptoms of pregnancy and meets at least one of the following criteria. She:
    • Has not had intercourse since the start of the last normal period.
    • Has been correctly and consistently using a reliable method of contraception.
      • Some experts would not regard condoms or natural family planning as reliable enough to exclude the possibility of pregnancy.
    • Is within 7 days after the start of a normal period.
    • Is within 7 days after abortion or miscarriage.
    • Is fully or nearly fully breastfeeding, amenorrhoeic, and less than 6 months postpartum.
    • Is not breastfeeding and less than 3 weeks postpartum, or has had no unprotected sex since delivery.
  • A pregnancy test can support the assessment, but only if 3 weeks have elapsed since the date of last intercourse.
Clarification / Additional information
  • These criteria are helpful in ruling out pregnancy in most clinical circumstances. However, other means must be used to exclude pregnancy when these criteria do not apply:
    • For example, the criteria cannot be used to exclude pregnancy in women who are 4 weeks or more postpartum and not breastfeeding, or in women who are amenorrhoeic and not less than 6 months postpartum.
Basis for recommendation
  • These criteria for ruling out pregnancy are recommended by the Faculty of Sexual and Reproductive Healthcare (FSRH), formerly the Faculty of Family Planning and Reproductive Healthcare (FFPRHC) [FFPRHC, 2002].
    • Inconsistency in current FFPRHC guidance with regard to requiring additional contraception between day 21 or 28 will be removed by the end of 2007 [Brechin, Personal Communication, 2007].

What should I do if pregnancy cannot be excluded?

  • If pregnancy cannot be excluded (for example, following emergency contraception) but the woman wishes to start contraception without delay, the following methods can be used:
    • Combined hormonal contraception (pill, patch, vaginal ring).
    • Progestogen-only pill.
    • Progestogen-only implant.
  • If pregnancy cannot be excluded and the woman's preferred method is not available or appropriate, combined hormonal contraception or the progestogen-only pill can be used as a bridging method.
  • In either case, the woman should be informed of the potential risks and of the need to have a pregnancy test 3 weeks after the last episode of unprotected sex.
Basis for recommendation
  • The recommendations are based on the guidance Quick starting contraception issued by the Faculty of Reproductive and Sexual Healthcare (FSRH) [FSRH, 2010e].
    • Inadvertent fetal exposure to contraceptive hormones is common. A USA study estimated that about 70,000 fetuses are exposed to oral contraceptive annually. Most of the data on fetal outcomes relates to COC. The available data do not suggest that the COC is associated with any specific abnormalities.

Influence of age and specific health conditions on contraceptive choice

Under 18 years: how does this influence choice?

Provided that there are no medical contraindications, a girl should be enabled to use her chosen method of contraception.

  • From menarche to 17 years of age:
    • Combined hormonal contraception (the pill, vaginal ring, or patch), the progestogen-only pill or implant, and barrier methods can be used.
    • The benefits of long-acting reversible contraception should be highlighted.
    • Depot medroxyprogesterone acetate or an intrauterine device or system can be used in young women under the age of 18 years, after consideration of other methods.
  • Before menarche:
    • Sexually active girls who have not yet started menstruating should be advised against regular hormonal contraception.
    • Advocate the use of condoms — as a contraceptive and to prevent sexually transmitted infection.
  • Give advice about prevention of sexually transmitted infections.
    • The correct and consistent use of condoms should be advised to reduce the risk of sexually transmitted infections.
    • Young people should be advised to get tested for sexually transmitted infections 2 and 12 weeks after unprotected sexual intercourse.
  • Concerns about possible effects — reassure girls and young women that:
    • Bone mineral density is influenced by normal pubertal development, exercise, diet, smoking, and some hormonal contraception.
      • The use of depot medroxyprogesterone acetate is associated with a small loss of bone mineral density which is usually recovered after discontinuation.
      • However, this should not deter a girl should she choose a progestogen-only injectable over other contraceptive methods, provided that she is not at increased risk for osteoporosis.
    • Risk of cancer — combined oral contraceptives (COC) use is not associated with an overall increased risk of cancer.
      • COCs reduce the risk of ovarian and endometrial cancer and, with less than 5 years' use, do not increase the risk of cervical cancer.
      • Depot medroxyprogesterone acetate does not appear to have any effect on the risk of ovarian, endometrial, or cervical cancer.
      • Any increase in risk of breast cancer associated with hormonal contraception is small, and there is no effect of duration of use.
    • Acne — COCs may improve acne vulgaris. The occurrence of acne can be a reason for discontinuing progestogen-only implants and progestogen-only injectables. Co-cyprindiol is indicated to treat severe acne which has not responded to oral antibiotics. The incidence of venous thromboembolism is about 4 times higher in women using co-cyprindiol than in women using low-dose oestrogen COCs. It should be withdrawn 3–4 months after the treated condition has resolved. If there is no improvement after 6 months consider withdrawing it. For more information see the CKS topic on Acne vulgaris.
    • Venous thromboembolism — the risk of venous thromboembolism is increased with use of COCs, but the absolute risk is very low. Progestogen-only contraceptives do not appear to increase the risk of venous thromboembolism.
    • Weight gain — there is no evidence of weight gain with use of COCs or patch. Weight gain may occur with depot medroxyprogesterone. However, weight gain is common in all women, and may simply reflect the normal increase in weight expected during the early reproductive years, and with changes in eating habits and activity levels.
    • Mood — it is unclear whether hormonal contraception has an adverse effect on mood.
    • Bleeding patterns and dysmenorrhoea — young women should be informed that altered bleeding patterns can occur with hormonal contraception use. However, dysmenorrhoea may improve with use of combined hormonal contraception.
Basis for recommendation
  • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Healthcare (FSRH), formerly the Faculty of Family Planning and Reproductive Healthcare (FFPRHC) [FFPRHC, 2004b; FFPRHC, 2007b; FSRH, 2010b], and those issued by the Committee on the Safety of Medicine regarding the use of cyproterone acetate and its risk of venous thromboembolism [CSM, 2002].

Approaching the menopause

How does the approach of menopause influence choice?

  • The usual (non age-related) UK Medical Eligibility Criteria apply, but if there are no other contraindications to use:
    • Methods that can be used without restriction by perimenopausal women include:
      • Copper intrauterine devices (IUDs), the levonorgestrel-releasing intrauterine system (IUS), progestogen-only pill, progestogen-only implants, barrier methods, and sterilization.
    • Progestogen-only injectables can be used without restriction up to the age of 45 years. In women over the age of 45 years, the benefits generally outweigh the risks.
    • Natural family planning is not generally recommended because irregular menstrual cycles in the menopause make this method difficult to learn and use.
    • Combined hormonal contraception (the combined contraceptive pill, patch, or vaginal ring) is not contraindicated by age alone in perimenopausal women, however:
      • It should not be used (unacceptable health risk) by women 35 years of age or older who smoke 15 or more cigarettes a day, or who develop migraine without aura while using combined hormonal contraception.
      • It is not usually recommended (risks usually outweigh the advantages) for women 35 years of age or older who smoke less than 15 cigarettes a day, or who quit smoking less than 1 year ago, or for women 35 years of age or older who have a history of migraine without aura.
      • Where the combined oral contraceptive (COC) pill is suitable, a pill containing 20 micrograms ethinylestradiol is a reasonable first choice.
  • Non-contraceptive benefits can influence the choice of contraceptive for women with:
    • Vasomotor symptoms (hot flushes): combined hormonal contraception may reduce symptoms.
      • Women experiencing menopausal symptoms while using combined hormonal contraception may wish to try an extended regimen.
    • Osteoporosis: combined hormonal contraception may increase bone mineral density; depot medroxyprogesterone acetate may reduce bone mineral density.
    • Menstrual pain, bleeding, and irregularity: combined hormonal contraception may reduce symptoms.
    • Menstrual pain: progestogen-only methods may reduce symptoms.
    • Heavy menstrual bleeding: the levonorgestrel-releasing IUS reduces menstrual bleeding and can cause amenorrhoea.
  • Hormone replacement therapy (HRT):
    • Women using combined HRT should not rely on this as contraception.
    • A progestogen-only pill can be used with combined sequential HRT to provide effective contraception and adequate endometrial protection (a progestogen-only pill used with oestrogen-only HRT will not provide an adequate level of endometrial protection; combined continuous HRT regimens are not appropriate in this age group due to bleeding).
    • The levonorgestrel–releasing IUS can be used as the progestogenic component for HRT for 5 years (the licence states 4 years), and provide concurrent contraception.
Basis for recommendation
  • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Healthcare [FSRH, 2010c].

How long should contraception be continued at the menopause?

  • The copper intrauterine device (IUD) and the levonorgestrel-releasing intrauterine system (IUS) can be retained longer during the perimenopause
    • Women who have an IUD inserted at age 40 years or older may retain the device until they no longer require contraception, even if this is beyond the duration of UK Marketing Authorisation.
    • Women who have an IUS inserted at age 45 years or older may retain the device until they no longer require contraception, even if this is beyond the duration of UK Marketing Authorisation.
  • Stopping non-hormonal contraception (copper intrauterine device, condoms) at the menopause
    • Women less than 50 years of age should continue contraception for 2 years after the last period.
    • Women aged 50 years or more should continue contraception for 1 year after the last period.
  • Stopping hormonal contraception at the menopause
    • Menstrual bleeding patterns are unhelpful in determining menopause when a woman is using hormonal contraception. Amenorrhoea may be due to contraceptive hormones (progestogen-only pills, progestogen-only injectables and implants, or the levonorgestrel-releasing IUS). Regular bleeding may be due to use of combined oral contraceptives.
    • Combined hormonal contraception (pill, patch or vaginal ring) or a progestogen-only injectable
      • Switch to another suitable contraceptive method at 50 years of age (amenorrhoea may not indicate the menopause).
      • Condoms or another method should be used for 2 years after stopping progestogen-only injectables (return of ovulation can be delayed).
      • The follicle-stimulating hormone (FSH) level is not a reliable indicator of ovarian failure in women using combined hormones, even if measured during the hormone-free interval.
    • Progestogen-only pills, progestogen-only implants, or levonorgestrel-releasing IUS
      • Continue use to age 55 years, when natural loss of fertility can be assumed for most women (96%), or
      • For women over the age of 50 years who are amenorrhoeic, check FSH on two occasions, with an interval of 6 weeks between tests. If both levels are more than 30 IU/L, this is highly suggestive of ovarian failure, and contraception may be stopped after 1 more year.
Basis for recommendation

How do anticonvulsants, antibiotics, antifungals, antiretrovirals and St John's wort influence choice?

Anticonvulsants

  • For women taking anticonvulsants, see Epilepsy.

Antibiotics

  • No contraceptive reduces the antibiotic effect but in certain circumstances the contraceptive effect is reduced.
  • For women taking antibiotics that induce liver enzymes (rifampicin and rifabutin):
    • Methods that can be used without restriction: depot medroxyprogesterone, copper intrauterine devices (IUDs), the levonorgestrel-releasing intrauterine system (IUS), barrier methods, and natural family planning methods.
    • Methods that generally can be used (advantages generally outweigh the risks): progestogen-only implant or depot norethisterone enantate (the consistent use of condoms is also recommended).
    • Methods that should not usually be used (risks usually outweigh the benefits): combined oral contraceptives (COCs), combined contraceptive patch, combined contraceptive vaginal ring, progestogen-only pill.
  • For women taking antibiotics that do not induce liver enzymes:
    • Methods that can be used without restriction: progestogen-only pill, progestogen-only injectables and implants, copper IUDs, the levonorgestrel-releasing IUS, and barrier methods.
    • Methods that generally can be used (advantages generally outweigh the risks): COCs, combined contraceptive patch, and combined contraceptive vaginal ring.
      • Additional protection (such as condoms) should be used for the first three weeks of a long antibiotic course, and during a short antibiotic course and for up to 7 days after stopping it.
      • Note: the combined contraceptive vaginal ring can be used with amoxicillin and doxycyline without the need for additional barrier contraception.
    • There are no methods that should not be used.

Antifungals

  • Women taking fluconazole, itraconazole, and ketoconazole, and griseofulvin: all methods can be used without restriction. Note: antifungal pessaries may increase the risk of ring breakage if used with a combined contraceptive vaginal ring.

Antiparasitics

  • All methods can be used without restriction.

Antiretroviral therapy

  • Antiretroviral drugs have the potential to either decrease or increase the bioavailability of steroid hormones in hormonal contraceptives. These interactions may alter the safety and effectiveness of the hormonal contraceptive and the antiretroviral drug. Consider consulting a specialist as advances in knowledge are rapid in this area.
  • If a woman on antiretroviral therapy decides to start or continue a hormonal contraceptive, the consistent use of condoms is recommended to prevent HIV transmission and to compensate for potential reductions in the effectiveness of the hormonal contraceptive.
  • Nucleoside reverse transcriptase inhibitors:
    • Methods that can be used without restriction: COCs, combined contraceptive patch, combined contraceptive vaginal ring, progestogen-only pill, depot medroxyprogesterone, and progestogen-only implants.
    • Methods that generally can be used (advantages generally outweigh the risks): copper IUDs and the levonorgestrel-releasing IUS can be inserted or continued if the woman is clinically well on antiretroviral therapy. However, if the woman is not clinically well, a copper IUD or the levonorgestrel-releasing IUS should not usually be inserted (the risks usually outweigh the advantages). Depot norethisterone enantate can generally be used.
  • Non-nucleoside reverse transcriptase inhibitors:
    • Methods that can be used without restriction: depot medroxyprogesterone.
    • Methods that generally can be used (advantages generally outweigh the risks): COCs, combined contraceptive patch, combined contraceptive vaginal ring, progestogen-only pill, progestogen-only implants, depot norethisterone enantate. Copper IUDs and the levonorgestrel-releasing IUS can be inserted or continued if the woman is clinically well on antiretroviral therapy. However, if the woman is not clinically well, a copper IUD or the levonorgestrel-releasing IUS should not usually be inserted (the risks usually outweigh the advantages).
  • Ritonavir-boosted protease inhibitors:
    • Methods that can be used without restriction: depot medroxyprogesterone.
    • Methods that generally can be used (advantages generally outweigh the risks): progestogen-only implants, depot norethisterone enantate. Copper IUDs and the levonorgestrel-releasing IUS can be inserted or continued if the woman is clinically well on antiretroviral therapy. However, if the woman is not clinically well, a copper IUD or the levonorgestrel-releasing IUS should not usually be inserted (the risks usually outweigh the advantages).
    • Methods that should not usually be used (risks usually outweigh the benefits): combined oral contraceptives (COCs), combined contraceptive patch, combined contraceptive vaginal ring, and progestogen-only pills.
  • Sterilization can be done with extra precautions, and the procedure may need to be delayed if the woman has an AIDS-related illness. The consistent use of condoms is recommended after sterilization.

St John's wort

  • Methods that can be used without restriction: progestogen-only injectables, copper IUDs, levonorgestrel-releasing IUS, barrier methods, natural family planning methods, and sterilization.
  • Methods that should not usually be used (risks usually outweigh the benefits): COCs, combined contraceptive patch, combined contraceptive vaginal ring, progestogen-only pill, and progestogen-only implants.
Basis for recommendation
  • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Healthcare (FSRH), formerly the Faculty of Family Planning and Reproductive Healthcare (FFPRHC) [FFPRHC, 2005d; FFPRHC and BASHH, 2006; FSRH, 2009b].
  • Drugs that induce liver enzymes may reduce the efficacy of hormonal contraception by increasing the metabolism of ethinyl estradiol and progestogens.
  • Some antibiotics that do not induce liver enzymes can temporarily reduce the efficacy of some hormonal contraceptives by altering colonic bacteria. Therefore women using these antibiotics should use additional protection (such as condoms) for the first three weeks of a long antibiotic course, and during a short antibiotic course and for up to 7 days after stopping it.
  • The recommendations relating to the combined contraceptive vaginal ring are based on the Summary of Product Characteristics of NuvaRing® [ABPI Medicines Compendium, 2009b] and a New product review from the Faculty of Sexual and Reproductive Healthcare (FSRH), formerly the Faculty of Family Planning and Reproductive Healthcare (FFPRHC) [FSRH, 2009a].

Breastfeeding: how does this influence choice?

  • Contraception is not needed in the first 20 days after delivery, but is required from day 21 if the woman is not fully breastfeeding and does not want to become pregnant.
  • Women who are breastfeeding and are less than 6 weeks postpartum
    • Methods that can be used without restriction: lactational amenorrhoea method (if fully or almost fully breastfeeding and amenorrhoeic), progestogen-only pill, progestogen-only implants, copper intrauterine devices (IUDs) and the levonorgestrel-releasing intrauterine system (IUS) (use within 48 hours or from 4 weeks after delivery), and barrier methods.
      • The National Institute for Health and Clinical Excellence recommends that the IUD and IUS be inserted at least 4 weeks after delivery.
    • Methods that can generally be used (advantages generally outweigh the risks): progestogen-only injectables.
    • Methods that are not usually recommended (risks usually outweigh the advantages): copper IUDs (from 48 hours up to 4 weeks after delivery) and the levonorgestrel-releasing IUS (from 48 hours up to 4 weeks after delivery).
    • Methods that should not be used (because of unacceptable health risk): combined oral contraceptives (COCs), combined contraceptive patch, and combined contraceptive vaginal ring.
    • Fertility awareness–based methods: a previous user can start from day 21, but a new user should delay learning to use the method until her periods start.
    • Sterilization is usually delayed until the woman is 6 weeks or more postpartum.
  • Women who are fully or almost fully breastfeeding and are between 6 weeks and 6 months postpartum
    • Methods that can be used without restriction: lactational amenorrhoea method (if amenorrhoeic), progestogen-only pill, progestogen-only injectables and implants, copper IUDs, levonorgestrel-releasing IUS, barrier methods, and sterilization.
    • Fertility awareness–based methods: a previous user can start, but a new user should delay learning to use the method until her periods start.
    • Methods that are not usually recommended: COCs, combined contraceptive patch, and combined contraceptive vaginal ring.
  • Women who are not fully or almost fully breastfeeding and are between 6 weeks and 6 months postpartum
    • Methods that can be used without restriction: progestogen-only pill, progestogen-only injectables and implants, copper IUDs, the levonorgestrel-releasing IUS, barrier methods, and sterilization.
    • Methods that can generally be used (advantages generally outweigh the risks): COCs, combined contraceptive patch, and combined contraceptive vaginal ring.
    • Fertility awareness–based methods: a previous user can start, but a new user should delay learning to use the method until her periods start.
    • There are no methods that should not be used (because of unacceptable health risk).
  • For women who are breastfeeding and are 6 months or more postpartum
    • Methods that can be used without restriction: COCs, combined contraceptive patch, combined contraceptive vaginal ring, progestogen-only pill, progestogen-only injectables and implants, copper IUDs, the levonorgestrel-releasing IUS, barrier methods, and sterilization.
    • Fertility awareness–based methods: a previous user can start, but a new user should delay learning to use the method until her periods start.
    • The lactational amenorrhoea method does not provide adequate protection from unplanned pregnancy after 6 months postpartum.
    • Fertility awareness–based methods should be delayed. Fertility signs and hormonal changes are unlikely to be detectable before 4 weeks postpartum.
    • Sterilization is usually delayed until the woman is 6 weeks or more postpartum.
Clarification / Additional information
  • Full and partial breastfeeding
    • The term postpartum includes any births, including stillbirths from 24 weeks' gestation.
    • Full breastfeeding is defined as exclusive when no other liquids or solids are given, and as almost exclusive when vitamins, water, or juice is given infrequently in addition to breastfeeds.
    • Partial breastfeeding is defined as:
      • High when the majority of feeds are breastfeeds.
      • Medium when about half of feeds are breastfeeds.
      • Low when the majority of feeds are not breastfeeds.
    • The term almost fully breastfeeding includes almost exclusive breastfeeding and high partial breastfeeding.

[FFPRHC, 2006a]

Basis for recommendation
  • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Health Care (FSRHC), formerly the Faculty of Family Planning and Reproductive Healthcare (FFPRHC) [FSRH, 2009b].
  • Combined hormonal contraceptives may reduce the volume of breast milk if used before 6 weeks postpartum.
  • Combined hormonal contraceptives do not appear to affect infant growth if used after 6 weeks postpartum, although the evidence of their effect on the quality and quantity of breast milk is poor.
  • Combined hormonal contraceptives can be used safely, but are unlikely to be required, in women who are fully or almost fully breastfeeding, amenorrhoeic, and less than 6 months postpartum.
  • The National Institute for Health and Clinical Excellence recommends that the IUD and IUS be inserted at least 4 weeks after delivery [National Collaborating Centre for Women's and Children's Health, 2005].

How does diabetes influence choice?

  • Women with diabetes mellitus (insulin and non–insulin dependent) and no vascular disease
    • Methods that can be used without restriction: copper intrauterine devices (IUDs), barrier methods, and natural family planning methods.
    • Methods that can generally be used (advantages generally outweigh the risks): combined oral contraceptives (COCs), combined contraceptive patch, combined contraceptive vaginal ring, progestogen-only pill, progestogen-only injectables and implants, and the levonorgestrel-releasing intrauterine system (IUS).
    • Sterilization should be undertaken with caution.
    • There are no methods that should not be used.
  • Women with diabetes mellitus and nephropathy, retinopathy, neuropathy, or other vascular disease
    • Methods that can be used without restriction: copper IUDs, barrier methods, and natural family planning methods.
    • Methods that can generally be used (advantages generally outweigh the risks): progestogen-only pill, progestogen-only implant, and the levonorgestrel-releasing IUS.
    • Methods that should not usually be used (risks usually outweigh the advantages): progestogen-only injectables.
    • COCs, the combined contraceptive patch, and the combined contraceptive vaginal ring should either not be used (unacceptable health risk) or should generally not be used (risks generally outweigh the advantages), depending on the severity of the vascular complications.
    • Sterilization can be used but should be done in a setting with experienced healthcare professionals and back-up medical support.
Basis for recommendation
  • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Health Care (FSRHC), formerly the Faculty of Family Planning and Reproductive Healthcare (FFPRHC) [FSRH, 2009b].

How does epilepsy influence choice?

  • Women with a history of epilepsy who are not taking anticonvulsants
    • All methods can be used without restriction.
  • Women taking anticonvulsants that do not induce liver enzymes (i.e. gabapentin, levetiracetam, sodium valproate, vigabatrin)
    • All methods can be used without restriction, except that sterilization should be undertaken with caution and seizures should be adequately controlled.
  • Women taking anticonvulsants that induce liver enzymes (phenytoin, carbamazepine, barbiturates, primidone, topiramate, oxcarbazepine)
    • Methods that can be used without restriction: depot medroxyprogesterone acetate, copper intrauterine devices, the levonorgestrel-releasing intrauterine system, barrier methods, and natural family planning methods.
    • Methods that can generally be used (benefits generally outweigh the risks): progestogen-only implant, depot norethisterone enantate.
    • Sterilization can be used with caution (with extra preparation, and counselling).
    • Methods that should not usually be used (risks usually outweigh the benefits): combined oral contraceptives, combined contraceptive patch, combined contraceptive vaginal ring, progestogen-only pill.
      • If combined oral contraceptives are chosen, dose adjustment may be needed. For more information about dose adjustment, see Liver enzyme-inducing drugs.
  • Women taking lamotrigine
    • Methods that can be used without restriction: progestogen-only pills, injectables and implants, copper intrauterine devices, the levonorgestrel-releasing intrauterine system, barrier methods, and natural family planning methods.
    • Methods that should not usually be used (risks usually outweigh the benefits): combined oral contraceptives, combined contraceptive patch, combined contraceptive vaginal ring.
      • If combined oral contraception is chosen, dose adjustment may be needed. For more information about dose adjustment, see Lamotrigine and Drug interactions.
Clarification / Additional information
  • Drugs that induce liver enzymes may reduce the efficacy of hormonal contraception by increasing the metabolism of ethinylestradiol and progestogens.
  • For details, see the UK Medical Eligibility Criteria.
Basis for recommendation
  • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Health Care (FSRHC), formerly the Faculty of Family Planning and Reproductive Health Care (FFPRHC) [FFPRHC, 2005d; MacGregor, 2007; FSRH, 2009b].

How does the presence of migrainous or non-migrainous headache influence choice?

  • Women with non-migrainous headaches
    • Methods that can be used without restriction: initiation of combined oral contraceptives (COCs), the combined contraceptive patch, combined contraceptive vaginal ring; progestogen-only pill, progestogen-only injectables and implants, copper intrauterine devices (IUDs), the levonorgestrel-releasing intrauterine system (IUS), barrier methods, and natural family planning.
    • Methods that can generally be used (advantages generally outweigh the risks): continuation of COCs, the combined contraceptive patch and combined contraceptive vaginal ring in women who develop non-migrainous headaches while taking combined hormonal contraceptives.
  • Women with migraine without aura, at any age
    • Methods that can be used without restriction: copper IUDs, initiation of progestogen-only pill, barrier methods, and natural family planning.
    • Methods that can generally be used (advantages generally outweigh risks): initiation of COCs, the combined contraceptive patch, combined contraceptive vaginal ring; continuation of progestogen-only pills; progestogen-only injectables and implants, the levonorgestrel IUS.
    • Methods that should generally not be used (risks usually outweigh advantages): continuation of COCs, the combined contraceptive patch, combined contraceptive vaginal ring.
  • Women with migraine with aura, at any age
    • Methods that can be used without restriction: copper IUDs, barrier methods, and natural family planning.
    • Methods that can generally be used (advantages generally outweigh the risks): progestogen-only pill, progestogen-only implants and injectables, and the levonorgestrel-releasing IUS.
    • Methods that should not be used (unacceptable risk): COCs, the combined contraceptive patch, and the combined contraceptive vaginal ring.
  • Women with a past history (>= 5 years ago) of migraine with aura, at any age
    • Methods that can be used without restriction: copper IUDs, barrier methods, and natural family planning.
    • Methods that can be used without restriction: initiation of the progestogen-only pill, copper IUDs, barrier methods, and natural family planning.
    • Methods that can generally be used (advantages generally outweigh the risks): the progestogen-only pill, progestogen-only implants and injectables, and the levonorgestrel-releasing IUS.
    • Methods that are not usually recommended (risks usually outweigh the advantages): COCs, the combined contraceptive patch, and combined contraceptive vaginal ring.
Clarification / Additional information
  • Aura are focal neurological symptoms that start before the headache. Aura are due to cerebral ischaemia, which causes such symptoms as visual disturbances, homonymous hemianopia, unilateral paraesthesia and/or numbness, unilateral weakness, and aphasia, or unclassifiable speech disorder.
  • For more information on cautions and contraindications when providing a contraceptive, see the UK Medical Eligibility Criteria.
  • Migraine without aura: managing increased frequency/severity of headache on starting combined hormonal contraception.
    • The UKMEC recommend that women who are using a combined hormonal contraceptive and have increased frequency or severity of migraine headaches should stop the contraceptive [FFPRHC, 2006a]. Although attacks may increase when combined hormonal contraceptives are initiated, there is usually improvement with continued use. Women can be advised that if headache or migraine increases in the first cycle of use, there is only a one in three chance of experiencing headache in the second cycle and a one in ten chance of experiencing headache in the third cycle [Loder et al, 2005]. There is no evidence that the risk of stroke is increased in these circumstances [MacGregor, 2007].
Basis for recommendation
  • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Health Care (FSRHC), formerly the Faculty of Family Planning and Reproductive Health Care (FFPRHC) [FSRH, 2009b].

How does the presence of hypertension influence choice?

  • Women with hypertension that is adequately controlled
    • Methods that can be used without restriction: progestogen-only pill, progestogen-only implants, copper intrauterine devices (IUDs), levonorgestrel-releasing intrauterine system (IUS), barrier methods, and natural family planning.
    • Methods that can generally be used (advantages generally outweigh risks): progestogen-only injectables.
    • Sterilization can be used with caution (extra preparation, precautions and counselling), with blood pressure controlled before surgery.
    • Methods that are not usually recommended (risks usually outweigh the advantages): combined oral contraceptives (COCs), the combined contraceptive patch, and combined contraceptive vaginal ring.
  • Women with consistently increased systolic blood pressure of more than 140 mmHg and less than 160 mmHg, or diastolic blood pressure more than 90 mmHg and less than 95 mmHg, without vascular disease:
    • Methods that can be used without restriction: progestogen-only pill, progestogen-only injectables and implants, copper intrauterine devices (IUDs), levonorgestrel-releasing intrauterine system (IUS), barrier methods, and natural family planning.
    • Sterilization can be used with caution (extra preparation, precautions and counselling), with blood pressure controlled before surgery.
    • Methods that are not usually recommended (risks usually outweigh the advantages): combined oral contraceptives (COCs), the combined contraceptive patch, and combined contraceptive vaginal ring.
  • Women with consistently increased systolic blood pressure 160 mmHg or more, or diastolic blood pressure 95 mmHg or more, without vascular disease
    • Methods that can be used without restriction: progestogen-only pill, progestogen-only implants, copper IUDs, levonorgestrel-releasing IUS, barrier methods, and natural family planning.
    • Methods that can generally be used (advantages generally outweigh the risks): progestogen-only injectables.
    • Sterilization can be used but should be done in a setting with experienced healthcare professionals and medical support. Blood pressure should be controlled before surgery.
    • Methods that should not be used (because of unacceptable risk): COCs, the combined contraceptive patch, and combined contraceptive vaginal ring.
  • Women with hypertension and vascular disease
    • Methods that can be used without restriction: copper IUDs, barrier methods, and natural family planning.
    • Methods that can generally be used (advantages generally outweigh the risks): progestogen-only pill, progestogen-only implants, and the levonorgestrel-releasing IUS.
    • Sterilization can be used but should be done in a setting with experienced healthcare professionals and medical support. Blood pressure should be controlled before surgery.
    • Methods that are not usually recommended (risks usually outweigh the advantages): progestogen-only injectables.
    • Methods that should not be used (because of unacceptable risk): COCs, the combined contraceptive patch, and combined contraceptive vaginal ring.
Basis for recommendation
  • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Health Care (FSRHC), formerly the Faculty of Family Planning and Reproductive Health Care (FFPRHC) [FSRH, 2009b].

How does menorrhagia, fibroids, or previous ectopic pregnancy influence choice?

  • Women with idiopathic menorrhagia
    • Methods that can be used without restriction: combined oral contraceptives (COCs), combined contraceptive patch, combined contraceptive vaginal ring, and the levonorgestrel-releasing intrauterine system (IUS) (initiation), which all may reduce menstrual blood loss; sterilization.
    • Methods that can generally be used (advantages generally outweigh the risks): progestogen-only pill (POP), progestogen-only injectables and implants, copper intrauterine devices (IUDs), the levonorgestrel-releasing IUS (continuation of use), barrier methods, and natural family planning methods (if the cycle is regular; if the cycle is irregular, a new user would find it more difficult to learn the method).
    • Consider:
      • The levonorgestrel IUS (Mirena®) as the first-line contraceptive option (licensed indication).
      • The COC as the second line contraceptive option.
      • The POP and progestogen-only injectables as third line contraceptive options.
    • For information on non-contraceptive treatments, see the CKS topic on Menorrhagia.
  • Women with a history of ectopic pregnancy
    • All methods can be used without restriction.
    • However, methods of contraception that inhibit ovulation (i.e. COCs, progestogen-only injectables and implants) are particularly suitable, as they reduce ectopic pregnancy to a greater degree compared with other methods.
  • Women with uterine fibroids
    • Without distortion of the uterine cavity: all methods can be used without restriction.
    • With distortion of the uterine cavity: copper IUDs and the levonorgestrel-releasing IUS should not be used if they cannot be easily fitted. All other methods can be used without restriction.
Basis for recommendation
  • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Health Care (FSRHC), formerly the Faculty of Family Planning and Reproductive Health Care (FFPRHC) [FSRH, 2009b], and the National Institute for Health and Clinical Excellence [NICE, 2007b].
  • Pharmacological treatments for heavy menstrual bleeding
    • NICE recommends that pharmacological treatments be considered in the following order:
      • Levonorgestrel-releasing intrauterine system (IUS) — provided long-term (at least 12 months) use is anticipated.
      • Tranexamic acid, or nonsteroidal anti-inflammatory drugs (NSAIDs), or combined oral contraceptives (COCs).
      • Norethisterone (15 mg) daily from days 5 to 26 of the menstrual cycle, or injected long-acting progestogens [NICE, 2007b].

How does the presence of multiple risk factors for cardiovascular disease influence choice?

  • Women with multiple risk factors for cardiovascular disease (e.g. older age, smoking, diabetes, hypertension, and obesity)
    • Methods that can be used without restriction: copper intrauterine devices (IUDs), barrier methods, and natural family planning.
    • Methods that can generally be used (advantages generally outweigh the risks): progestogen-only pill, progestogen-only implants, and the levonorgestrel-releasing intrauterine system (IUS).
    • Sterilization can be used but should be done in a setting with experienced healthcare professionals and back-up medical support.
    • Methods that are not usually recommended (risks usually outweigh the advantages): progestogen-only injectables.
    • Methods that should not be used (because of unacceptable risk): combined oral contraceptives, combined contraceptive patch, and combined contraceptive vaginal ring.
Basis for recommendation
  • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Health Care (FSRHC), formerly the Faculty of Family Planning and Reproductive Healthcare (FFPRHC) [FSRH, 2009b].

How does obesity influence choice?

  • Body mass index >= 30–34 kg/m2
    • Methods that can be used without restriction: progestogen-only pill, progestogen-only injectables and implants, copper intrauterine devices (IUDs), the levonorgestrel-releasing intrauterine system (IUS), barrier methods, and natural family planning.
    • Methods that can generally be used (advantages generally outweigh the risks): combined oral contraceptives (COCs), combined contraceptive patch, combined contraceptive vaginal ring.
    • Sterilization can be used with caution (i.e. extra preparation, precautions, and counselling).
    • There are no methods that should not be used (because of unacceptable risk).
  • Body mass index >= 35 kg/m2
    • Methods that can be used without restriction: progestogen-only pill, progestogen-only injectables and implants, copper IUDs, the levonorgestrel-releasing IUS, barrier methods, and natural family planning.
    • Sterilization can be used with caution (i.e. extra preparation, precautions, and counselling).
    • Methods that are not usually recommended (risks usually outweigh the advantages): COCs, combined contraceptive patch, combined contraceptive vaginal ring.
  • In addition, note that:
    • Weight greater than 70 kg — the desogestrel-only pill, Cerazette®, should be considered in preference to other progesterone only pills.
    • Weight greater than 90 kg — the combined contraceptive patch should not be used.
    • 'Heavier women' — the progestogen-only contraceptive implant may need to be removed earlier than the licensed 3 years.
Basis for recommendation
  • Obesity
    • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Health Care (FSRHC), formerly the Faculty of Family Planning and Reproductive Healthcare (FFPRHC) [FSRH, 2009b] and the Summary of Product Characteristics (SPC) of Evra® transdermal contraceptive patch [ABPI Medicines Compendium, 2009a].
    • For women who are obese and use combined oral contraceptives (COCs), the combined contraceptive patch, or combined contraceptive vaginal ring, there is an increased risk of:
      • Venous thromboembolism: compared with non-users, but the absolute risk of thromboembolism is still small. The risk of venous thromboembolism increases with increasing body mass index, and the use of COCs increases this risk further.
      • Contraceptive failure: compared with women who are not obese, but the data on the impact of obesity on the effectiveness of COCs are limited.
    • Women who are obese are more likely to have complications when undergoing sterilization. There is an increased risk of wound infection and disruption.
  • POP and weight greater than 70 kg
    • The FFPRHC on reviewing the available evidence concluded that POPs may be less effective in women who weigh more than 70 kg (except for the desogestrel-only pill, Cerazette®) [FFPRHC, 2007c].
  • The progestogen-only contraceptive implant and obesity
    • The manufacturer states that the contraceptive effect of Implanon® is related to the plasma levels of etonogestrel, which are inversely related to body weight, and decrease with time after insertion. The clinical experience with Implanon® in heavier women in the third year of use is limited. Therefore it cannot be excluded that the contraceptive efficacy in these women during the third year of use may be lower than for women of normal weight. Clinicians may therefore consider earlier replacement of the implant in heavier women [ABPI Medicines Compendium, 2006].

How does recent delivery and not breastfeeding influence choice?

  • Contraception is not needed in the first 20 days after delivery, but is required from day 21 if the woman does not want to become pregnant.
  • Women who are not breastfeeding and are less than 3 weeks postpartum
    • Methods that can be used without restriction: progestogen-only pill, progestogen-only injectables and implants, barrier methods, and natural family planning.
    • Methods that are not usually recommended (risks usually outweigh the advantages): combined oral contraceptive pill (COC), combined contraceptive patch, combined contraceptive vaginal ring, copper IUDs and the levonorgestrel-releasing IUS (use within 48 hours or from 4 weeks after delivery). Fertility awareness–based methods should be delayed — fertility signs and hormonal changes are unlikely to be detectable before 4 weeks postpartum.
    • Sterilization is usually delayed until the woman is 6 weeks or more postpartum.
  • Women who are not breastfeeding and are 3 weeks or more postpartum
    • Methods that can be used without restriction: COCs, combined contraceptive patch, combined contraceptive vaginal ring, progestogen-only pill, progestogen-only injectables and implants, copper IUDs and the levonorgestrel-releasing IUS (use within 48 hours or from 4 weeks after delivery), and barrier methods.
    • Fertility awareness–based methods: a previous user can start, but a new user should delay learning to use the method until her periods start.
    • Sterilization is usually delayed until the woman is 6 weeks or more postpartum.
    • There are no methods that should not be used (because of unacceptable health risk).
Basis for recommendation
  • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Health Care (FSRHC), formerly the Faculty of Family Planning and Reproductive Healthcare (FFPRHC) [FSRH, 2009b].
  • The National Institute for Health and Clinical Excellence recommends that the IUD and IUS be inserted at least 4 weeks after delivery [National Collaborating Centre for Women's and Children's Health, 2005].

How does the presence of, or increased risk for, a sexually transmitted infection or pelvic inflammatory disease influence choice?

  • Women with a history of pelvic inflammatory disease and with no current risk factors for sexually transmitted infection (STI)
      • All methods can be used without restriction.
  • Women with current pelvic inflammatory disease
    • Copper IUDs and the levonorgestrel-releasing IUS should not be inserted. However, there is generally no need for removal if the woman wishes to continue their use.
    • All other methods can be used without restriction.
  • Women with a current STI
    • Chlamydia, or purulent cervicitis or gonorrhoea infection:
      • Copper IUDs and the levonorgestrel-releasing IUS should not be inserted. However, there is generally no need for removal if the woman wishes to continue their use.
      • All other methods can be used without restriction.
    • Vaginitis, other STIs (excluding HIV and hepatitis), and increased risk of STIs:
      • Copper IUDs and the levonorgestrel-releasing IUS can generally be used (advantages generally outweigh the risks).
      • All other methods can be used without restriction.
Clarification / Additional information
Basis for recommendation
  • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Health Care (FSRHC), formerly the Faculty of Family Planning and Reproductive Health Care (FFPRHC) [FSRH, 2009b].

How does smoking influence choice?

  • Women less than 35 years of age and are currently smoking, or are 35 years of age or older and stopped smoking 12 or more months ago
    • Methods that can be used without restriction: progestogen-only pill, progestogen-only injectables and implants, copper intrauterine devices (IUDs), the levonorgestrel-releasing intrauterine system (IUS), barrier methods, natural family planning, and sterilization.
    • Methods that can generally be used (advantages generally outweigh the risks): combined oral contraceptives (COCs), combined contraceptive patch, and combined contraceptive vaginal ring.
    • There are no methods that should not be used (because of unacceptable risk).
  • Women 35 years of age or older who smoke less than 15 cigarettes daily, or have stopped smoking in the past 12 months
    • Methods that can be used without restriction: progestogen-only pill, progestogen-only injectables and implants, copper IUDs, the levonorgestrel-releasing IUS, barrier methods, natural family planning, and sterilization.
    • Methods that are not usually recommended (risks usually outweigh the advantages): COCs, combined contraceptive patch, and combined contraceptive vaginal ring.
  • Women 35 years of age or older who smoke 15 or more cigarettes daily
    • Methods that can be used without restriction: progestogen-only pill, progestogen-only injectables and implants, copper IUDs, the levonorgestrel-releasing IUS, barrier methods, natural family planning, and sterilization.
    • Methods that should not be used (because of unacceptable risk): COCs, combined contraceptive patch, and combined contraceptive vaginal ring.
Clarification / Additional information
  • Women who use combined oral contraceptives (COCs) and smoke are at increased risk of cardiovascular disease, especially myocardial infarction, compared with women who use COCs and do not smoke.
    • The risk of myocardial infarction increases with the number of cigarettes smoked daily.
    • Excess mortality from cigarette smoking is apparent from 35 years of age.
  • Women who stop smoking reduce their risk of cardiovascular disease:
    • After 1 year, the risk can be reduced by as much as 50%.
    • It may take up to 10 years to reach the risk level of people who have never smoked.

[FFPRHC, 2006a]

Basis for recommendation
  • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Health Care (FSRHC), formerly the Faculty of Family Planning and Reproductive Healthcare (FFPRHC) [FSRH, 2009b].
  • The guidance on the combined contraceptive vaginal ring is based on epidemiological data from combined oral contraceptives (COCs), as no specific data are currently available on the vaginal route of hormone administration. The warnings for COCs are considered applicable to the use of the combined contraceptive vaginal ring [ABPI Medicines Compendium, 2009b].

How does venous thromboembolism (current and risk factors for) influence choice?

  • Women with known thrombogenic mutations, history of venous thromboembolism, or taking anticoagulants for current venous thromboembolism
    • Methods that can be used without restriction: copper intrauterine devices (IUDs), barrier methods, and natural family planning.
    • Methods that can generally be used (advantages generally outweigh the risks): progestogen-only pill, progestogen-only implants and injectables, and the levonorgestrel-releasing intrauterine system (IUS).
    • Methods that should not be used (because of unacceptable risk): combined oral contraceptives (COCs), the combined contraceptive patch, and combined contraceptive vaginal ring.
Clarification / Additional information
Basis for recommendation
  • These recommendations are based on guidelines published by the Faculty of Sexual and Reproductive Health Care (FSRHC), formerly the Faculty of Family Planning and Reproductive Health Care (FFPRHC) [FSRH, 2009b].

UK Medical Eligibility Criteria for contraceptive methods

UK Medical Eligibility Criteria for use of combined hormonal methods (pills, patch, vaginal ring)

The UK Medical Eligibility Criteria (UKMEC) are a set of evidence-based recommendations designed to help women select the most appropriate method of contraception for specific clinical conditions without imposing unnecessary restrictions [FSRH, 2009b]. Each clinical condition has a recommendation for contraceptive use, categorized according to the balance of benefits and harms weighted by their probabilities for the typical user with the condition. The categories are defined in Table 1, and the eligibility criteria in Table 2.

Table 1. UK Medical Eligibility Criteria (UKMEC).
Category
Definition
UKMEC 1
A condition for which there is no restriction for the use of the contraceptive method.
UKMEC 2
A condition where the advantages of using the method generally outweigh the theoretical or proven risks.
UKMEC 3
A condition where the theoretical or proven risks usually outweigh the advantages of using the method.
Provision of a method to a woman with a condition given a UKMEC Category 3 requires expert clinical judgement and/or referral to a specialist contraceptive provider since use of the method is not usually recommended unless other methods are not available or not acceptable.
UKMEC 4
A condition which represents an unacceptable health risk if the contraceptive method is used.
Source: [FSRH, 2009b]

Table 2 summarizes the UK Medical Eligibility Criteria for use of a combined hormonal contraceptive method, i.e. combined oral contraceptive (COC), combined contraceptive patch, and combined contraceptive vaginal ring.

Table 2. UK Medical Eligibility Criteria (UKMEC) for use of a combined hormonal contraceptive method (combined oral contraceptive, combined contraceptive patch, combined contraceptive vaginal ring).
Clinical feature
UKMEC 1
No restrictions
UKMEC 2
Advantages generally outweigh risks
UKMEC 3
Requires expert clinical judgement
UKMEC 4
Contraindicated
Age
Menarche to < 40 years
>= 40 years*
Parity
Nulliparous
Parous
Breastfeeding
>= 6 months postpartum
Between 6 weeks and 6 months postpartum, and partially breastfeeding (medium to low)
Between 6 weeks and 6 months postpartum, and fully or almost fully breastfeeding
< 6 weeks postpartum
Postpartum, and not breastfeeding
>= 21 days postpartum
< 21 days postpartum
Post-abortion
First- and second-trimester abortion
Immediately after septic abortion
Ectopic pregnancy
History of ectopic pregnancy
Smoking
Age < 35 years
Age >= 35 years and stopped smoking >= 1 year ago
Age >= 35 years and smoking < 15 cigarettes per day
Age >= 35 years and stopped smoking < 1 year ago
Age >= 35 years and smoking >= 15 cigarettes per day
Current and history of ischaemic heart disease
Stroke
Obesity
Body mass index (BMI) between 30 and 34 kg/m2
Body mass index >= 35 kg/m2
Blood pressure
History of high blood pressure during pregnancy
Adequately controlled hypertension
Consistently elevated blood pressure: systolic 140–159 mmHg, or diastolic 90–94 mmHg
Systolic blood pressure >= 160 mmHg, or diastolic >= 95 mmHg
Vascular disease
Surgery
History of pelvic surgery
Minor surgery without immobilization
Major surgery without prolonged immobilization
Major surgery with prolonged immobilization
Raynaud's disease
Primary Raynaud's disease
Secondary Raynaud's disease (without lupus anticoagulant)
Secondary Raynaud's disease (with lupus anticoagulant)
Systemic lupus erythematosus
SLE (alone); with severe thrombocytopaenia; immunosuppressive treatment
SLE with positive (or unknown) antiphospholipid antibodies
Other risk factors for venous thromboembolism (VTE)
Varicose veins
Family history of VTE in a first-degree relative age >= 45 years
Superficial thrombophlebitis
Family history of VTE in a first-degree relative age < 45 years
Immobility (unrelated to surgery), e.g. wheelchair use, debilitating illness
Current VTE (on anticoagulants) or history of VTE
Known thrombogenic mutations, e.g. Factor V Leiden, Prothrombin mutation, Protein S, Protein C, Antithrombin deficiencies
Headaches
For initiation
Non-migrainous headaches (mild or severe)
For initiation
Migraine headaches without aura at any age
For continuation
Non-migrainous headaches (mild or severe)
For continuation
Migraine headaches without aura at any age
For initiation and continuation
History (>=5 years ago) of migraine with aura at any age
For initiation and continuation
Migraine headaches with aura at any age
Epilepsy
Epilepsy and not using a liver enzyme–inducing drug
Psychological conditions
Depressive disorders
Breast disease
For initiation and continuation
Benign breast disease or a family history of breast cancer
For continuation
Undiagnosed mass in breast
For initiation
Undiagnosed mass in breast
For initiation and continuation
History of breast cancer and no evidence of recurrence for 5 years
Carriers of known gene mutations associated with breast cancer (e.g. BRCA1)
For initiation and continuation
Current breast cancer
Vaginal bleeding
Irregular pattern (light, or heavy bleeding), but not suspicious
Heavy or prolonged bleeding
Unexplained vaginal bleeding (before evaluation) suspicious for serious underlying condition
Other gynaecological conditions
Endometriosis
Benign ovarian tumour
Severe dysmenorrhoea
Gestational trophoblastic disease (GTD) when hCG is decreasing or undetectable; or when persistently elevated hCG or malignant disease
Cervical ectropion
Endometrial or ovarian cancer
Uterine fibroids — with or without distortion of the uterine cavity
CIN and cervical cancer
Cardiovascular conditions
Valvular and congenital heart disease: uncomplicated
Multiple risk factors for arterial cardiovascular disease
Multiple risk factors for arterial cardiovascular disease
Valvular and congenital heart disease: complicated (e.g. by pulmonary hypertension, atrial fibrillation, or history of subacute bacterial endocarditis)
Current and history of ischaemic heart disease
Stroke including TIA
Gastrointestinal conditions
Viral hepatitis: carrier or chronic
Cirrhosis: mild (compensated without complications)
For continuation
Viral hepatitis: acute or flare
Gallbladder disease: asymptomatic or treated by cholecystectomy
History of cholestasis: pregnancy-related
Benign liver tumours (focal nodular hyperplasia)
Inflammatory bowel disease
Gallbladder disease: symptomatic medically treated or current
History of cholestasis: past COC-related
For initiation
Viral hepatitis: acute or flare
(Category given will depend on disease severity)
Cirrhosis: severe (decompensated)
Benign liver tumours (hepatocellular adenoma)
Malignant liver tumours (hepatoma)
For initiation
Viral hepatitis: acute or flare
(Category given will depend on disease severity)
Infections
Pelvic inflammatory disease: current or past history of (assuming no risk factors for STIs)
STI: current purulent cervicitis, chlamydial infection, or gonorrhoea
Vaginitis (including Trichomonas and bacterial vaginosis)
Increased risk of STIs
HIV: high risk of HIV; current HIV not using antiretroviral therapy;
HIV: using antiretroviral therapy
Viral hepatitis: carrier
Other STIs
Schistosomiasis
Pelvic and non-pelvic tuberculosis
Malaria
HIV: using antiretroviral therapy
AIDS
HIV: using antiretroviral therapy
Viral hepatitis: active disease
Diabetes
History of gestational diabetes
Non-vascular disease: NIDDM and IDDM
Nephropathy, retinopathy, neuropathy
Other vascular disease
(Category given will depend on disease severity)
Nephropathy, retinopathy, neuropathy
Other vascular disease
(Category given will depend on disease severity)
Thyroid
Simple goitre, hypothyroid, hyperthyroid
Haematological conditions
Anaemias: thalassaemia, iron deficiency
Sickle cell disease
Dyslipidaemia
Known dyslipidaemia
(Category given will depend on disease severity)
Known dyslipidaemia
(Category given will depend on disease severity)
Antiretroviral therapy drug interactions
(and consistent use of condoms is recommended)
Nucleoside reverse transcriptase inhibitors
Non-nucleoside reverse transcriptase inhibitors
Ritonavir-boosted protease inhibitors
Anticonvulsant therapy drug interactions
(and consistent use of condoms is recommended)
Certain anticonvulsants (phenytoin, carbamazepine, barbiturates, primidone, topiramate, oxcarbazepine)
Lamotrigine
Antimicrobial therapy drug interactions
(and consistent use of condoms is recommended)
Broad spectrum antibiotics
Antifungals
Antiparasitics
Rifampicin or rifabutin therapy
* Age >= 40 years: women may use combined oral contraception until age 50 years if there are no medical contraindications.
BMI = body mass index; COC = combined oral contraceptive; CIN = cervical intraepithelial neoplasia; hCG = human chorionic gonadotrophin; IDDM = insulin-dependent diabetes mellitus; NIDDM = non–insulin-dependent diabetes mellitus; STI = sexually transmitted infection; SLE = systemic lupus erythematosus; VTE = venous thromboembolism.
† The consistent use of condoms is recommended, as antiretroviral drugs may reduce the effectiveness of hormonal contraceptives. Similarly, certain anticonvulsants and lamotrigine, rifampicin and rifabutin therapy can reduce the effectiveness of combined oral contraception. When using these drugs, a COC preparation containing a minimum of 30 micrograms of ethinylestradiol should be used.
Adapted from: [FSRH, 2009b]

UK Medical Eligibility Criteria for use of progestogen-only contraceptive methods (pills, injectables and implant)

UK Medical Eligibility Criteria for use of progestogen-only pills

The UK Medical Eligibility Criteria are a set of evidence-based recommendations designed to help women select the most appropriate method of contraception for specific clinical conditions without imposing necessary restrictions [FSRH, 2009b]. Each clinical condition has a recommendation for contraceptive use, categorized according to the balance of benefits and harms weighted by their probabilities for the typical user with the condition. The categories are defined in Table 1. Table 2 describes the UK Medical Eligibility Criteria for use of progestogen-only pills.

Table 1. UK Medical Eligibility Criteria (UKMEC).
Category
Definition
UKMEC 1
A condition for which there is no restriction for the use of the contraceptive method.
UKMEC 2
A condition where the advantages of using the method generally outweigh the theoretical or proven risks.
UKMEC 3
A condition where the theoretical or proven risks usually outweigh the advantages of using the method.
Provision of a method to a woman with a condition given a UKMEC Category 3 requires expert clinical judgement and/or referral to a specialist contraceptive provider since use of the method is not usually recommended unless other methods are not available or not acceptable.
UKMEC 4
A condition which represents an unacceptable health risk if the contraceptive method is used.
Source: [FSRH, 2009b]
Table 2. UK Medical Eligibility Criteria (UKMEC) for use of progestogen-only pills.
Clinical feature
UKMEC 1
No restrictions
UKMEC 2
Advantages generally outweigh risks
UKMEC 3
Requires expert clinical judgement
UKMEC 4
Contraindicated
Age
Menarche to > 45 years
Parity
Nulliparous
Parous
Breastfeeding
< 6 weeks postpartum
or >= 6 weeks to < 6 months postpartum fully or partially (medium to low) breastfeeding
or >= 6 months postpartum
Postpartum, not breastfeeding
At any time
(although contraception is not necessary until 21 days after delivery)
Post-abortion
First- and second-trimester abortion
Immediately after septic abortion
Ectopic pregnancy
History of ectopic pregnancy
Smoking
Past or current smoker
Obesity
Body mass index >= 30 kg/m2
Blood pressure
Adequately controlled hypertension
Consistently elevated blood pressure: systolic > 140–159 mmHg or diastolic > 90–94 mmHg
Systolic > 160 or diastolic > 95 mmHg
History of high blood pressure during pregnancy
Vascular disease
Surgery
History of pelvic surgery
Major surgery without prolonged immobilization
Minor surgery without immobilization
Major surgery with prolonged immobilization
Other risk factors for venous thromboembolism
Family history of VTE in a first-degree relative
Immobility (unrelated to surgery): e.g. wheelchair use, debilitating illness
Varicose veins
Superficial thrombophlebitis
History of VTE or current VTE (on anticoagulants)
Known thrombogenic mutations, e.g. Factor V Leiden, Prothrombin mutation, Protein S, Protein C, Antithrombin deficiencies
Raynaud's disease
Primary
Secondary with and without lupus anticoagulant
Systemic lupus erythematosus
SLE alone; with severe thrombocytopaenia; immunosuppressive treatment
SLE with positive (or unknown) antiphospholipid antibodies
Headaches
For initiation and continuation
Non-migrainous headaches (mild or severe)
For initiation
Migraine headaches without aura (any age)
For continuation
Migraine headaches without aura, any age
For initiation and continuation
Migraine headaches with aura, any age
Past history (>= 5 years ago) of migraine with aura, any age
Epilepsy
Epilepsy and not using liver enzyme–inducing drugs
Psychological conditions
Depressive disorders
Breast disease
Benign breast disease or family history of breast cancer
Undiagnosed mass
Carriers of known gene mutations associated with breast cancer (e.g. BRCA1)
History of breast cancer and no evidence of recurrence for 5 years
Current breast cancer
Unexplained vaginal bleeding
Irregular pattern (light or heavy bleeding), but not suspicious
Heavy or prolonged bleeding
Unexplained vaginal bleeding (before evaluation) suspicious for serious underlying condition
Other gynaecological conditions
Endometriosis
Benign ovarian tumours, including cysts
Severe dysmenorrhoea
Gestational trophoblastic disease (GTD) when hCG is decreasing or undetectable; when hCG is persistently elevated or malignant disease
Cervical ectropion
CIN
Cervical cancer (awaiting treatment)
Endometrial or ovarian cancer
Uterine fibroids with or without distortion of the uterine cavity
Cardiovascular conditions
Valvular and congenital heart disease: uncomplicated
Valvular and congenital heart disease complicated (e.g. by pulmonary hypertension, atrial fibrillation, or history of subacute bacterial endocarditis)
For initiation
Stroke
Current and history of ischaemic heart disease
Multiple risk factors for arterial cardiovascular disease
For continuation
Stroke
Current and history of ischaemic heart disease
Gastrointestinal conditions
History of cholestasis related to pregnancy
Viral hepatitis: acute or flare; carrier; or chronic
Cirrhosis: mild (compensated)
Gallbladder disease: asymptomatic, symptomatic treated by cholecystectomy, medically treated or current
History of cholestasis related to combined oral contraception
Liver tumours: benign (focal nodular hyperplasia)
Inflammatory bowel disease
Cirrhosis: severe (decompensated)
Liver tumours: benign (hepatocellular adenoma) and malignant (hepatoma)
Infections
Pelvic inflammatory disease: current or past history of (assuming no risk factors for STIs)
STI: vaginitis, current purulent cervicitis, chlamydial infection, gonorrhoea; or increased risk of STI
HIV: high risk of HIV; current HIV not using antiretroviral therapy
HIV: using antiretroviral therapy
Schistosomiasis
Pelvic and non-pelvic tuberculosis
Malaria
HIV: using antiretroviral therapy
AIDS
HIV: using antiretroviral therapy
Diabetes
History of gestational diabetes
NIDDM and IDDM, non-vascular disease
With nephropathy, retinopathy or neuropathy;
Other vascular disease
Thyroid
Simple goitre, hypothyroid, hyperthyroid
Haematological conditions
Anaemias: thalassaemia, iron deficiency, sickle cell disease
Dyslipidaemia
Known dyslipidaemias
Antiretroviral therapy drug interactions
(and consistent use of condoms is recommended)
Nucleoside reverse transcriptase inhibitors
Non-nucleoside reverse transcriptase inhibitors
Ritonavir-boosted protease inhibitors
Anticonvulsant therapy drug interactions
(and consistent use of condoms is recommended)
Lamotrigine
Certain anticonvulsants (phenytoin, carbamazepine, barbiturates, primidone, topiramate, oxcarbazepine)
Antimicrobial therapy
(and consistent use of condoms is recommended)
Broad spectrum antibiotics
Antifungals
Antiparasitics
Rifampicin or rifabutin therapy
BMI = body mass index; CIN = cervical intraepithelial neoplasia; hCG = human chorionic gonadotrophin; IDDM = insulin-dependent diabetes; NIDDM = non–insulin-dependent diabetes; STI = sexually transmitted infection; SLE = systemic lupus erythematosus; VTE = venous thromboembolism.
† The consistent use of condoms is recommended, as antiretroviral drugs may reduce the effectiveness of hormonal contraceptives. Similarly, the interaction of certain anticonvulsants, rifampicin or rifabutin, and POPs is likely to reduce the effectiveness of POPs.
Adapted from: [FSRH, 2009b]

UK Medical Eligibility Criteria for progestogen-only injectables

The UK Medical Eligibility Criteria are a set of evidence-based recommendations designed to help women select the most appropriate method of contraception for specific clinical conditions without imposing necessary restrictions [FSRH, 2009b]. Each clinical condition has a recommendation for contraceptive use, categorized according to the balance of benefits and harms weighted by their probabilities for the typical user with the condition. The categories are defined in Table 1. Table 2 describes the UK Medical Eligibility Criteria for use of progestogen-only injectables.

Table 1. UK Medical Eligibility Criteria (UKMEC).
Category
Definition
UKMEC 1
A condition for which there is no restriction for the use of the contraceptive method.
UKMEC 2
A condition where the advantages of using the method generally outweigh the theoretical or proven risks.
UKMEC 3
A condition where the theoretical or proven risks usually outweigh the advantages of using the method.
Provision of a method to a woman with a condition given a UKMEC Category 3 requires expert clinical judgement and/or referral to a specialist contraceptive provider since use of the method is not usually recommended unless other methods are not available or not acceptable.
UKMEC 4
A condition which represents an unacceptable health risk if the contraceptive method is used.
Source: [FSRH, 2009b]
Table 2. UK Medical Eligibility Criteria (UKMEC) for use of depot medroxyprogesterone acetate (DMPA) and norethisterone enantate (NET-EN).
Clinical feature
UKMEC 1
No restrictions
UKMEC 2
Advantages generally outweigh risks
UKMEC 3
Requires expert clinical judgement
UKMEC 4
Contraindicated
Age
18–45 years
Menarche to < 18 years
> 45 years
Parity
Nulliparous
Parous
Breastfeeding
>= 6 weeks to < 6 months postpartum fully or partially breastfeeding
or >= 6 months postpartum
< 6 weeks postpartum
Postpartum, not breastfeeding
At any time
(although contraception is not necessary until 21 days after delivery)
Post-abortion
First- and second-trimester abortion
Immediately after septic abortion
Ectopic pregnancy
History of ectopic pregnancy
Smoking
Past or current smoker
Obesity
BMI >= 30 kg/m2
Blood pressure
Consistently elevated blood pressure: systolic > 140–159 mmHg or diastolic > 90–94 mmHg
History of high blood pressure during pregnancy
Adequately controlled hypertension
Consistently elevated blood pressure: systolic > 160 or diastolic > 95 mmHg
Vascular disease
Surgery
Major surgery without prolonged immobilization
Minor surgery without immobilization
History of pelvic surgery
Major surgery with prolonged immobilization
Other risk factors for venous thromboembolism
Family history of VTE in a first degree relative
Immobility (unrelated to surgery), e.g. wheelchair use, debilitating illness
Varicose veins
Superficial thrombophlebitis
History of VTE
Known thrombogenic mutations, e.g. Factor V Leiden, Prothrombin mutation, Protein S, Protein C, Antithrombin deficiencies
Current VTE (on anticoagulants)
Raynaud's disease
Primary Raynaud's disease
Secondary without lupus anticoagulant
Secondary Raynaud's disease with lupus anticoagulant
Systemic lupus erythematosus
 
SLE alone
Immunosuppressive treatment
For continuation
With severe thrombocytopenia
Positive (or unknown) antiphospholipid antibodies
For initiation
With severe thrombocytopenia
 
Headaches
For initiation and continuation
Non-migrainous headaches (mild or severe)
For initiation and continuation
Migraine headaches without aura (any age)
Migraine headaches with aura (any age)
Past history (>= 5 years ago) of migraine with aura (any age)
Epilepsy
Epilepsy
Psychological conditions
Depressive disorders
Breast disease
Benign breast disease or a family history of breast cancer
Undiagnosed mass
Carriers of known gene mutations associated with breast cancer (e.g. BRCA1)
History of breast cancer and no evidence of recurrence for 5 years
Current breast cancer
Vaginal bleeding
Irregular pattern (light, or heavy bleeding), but not suspicious
Heavy or prolonged bleeding
Unexplained vaginal bleeding (before evaluation) suspicious for serious underlying condition
Other gynaecological conditions
Endometriosis
Benign ovarian tumours, including cysts
Severe dysmenorrhoea
Gestational trophoblastic disease when hCG is normal, persistently elevated or malignant disease
Cervical ectropion
Endometrial cancer
Ovarian cancer
Uterine fibroids with or without distortion of the uterine cavity
CIN
Cervical cancer (awaiting treatment)
Cardiovascular conditions
Valvular and congenital heart disease: uncomplicated
Valvular and congenital heart disease: complicated (e.g. by pulmonary hypertension, atrial fibrillation, or history of subacute bacterial endocarditis)
Multiple risk factors for arterial cardiovascular disease
Stroke including TIA
Current and history of ischaemic heart disease
Gastrointestinal conditions
History of cholestasis: pregnancy-related
Inflammatory bowel disease
Viral hepatitis: acute or flare, carrier or chronic disease
Cirrhosis: mild compensated disease
Gallbladder disease: asymptomatic, symptomatic treated by cholecystectomy, medically treated or current
History of cholestasis: related to combined oral contraceptive
Liver tumours: benign (focal nodular hyperplasia)
Cirrhosis: severe decompensated disease
Liver tumours: benign (hepatocellular adenoma) and malignant (hepatoma)
Infections
Pelvic inflammatory disease: current or past (assuming no risk factors for STIs)
STIs: vaginitis, current purulent cervicitis or gonorrhoea, chlamydial infection (symptomatic or asymptomatic); or increased risk of STIs
High risk of HIV
HIV: not using anti-retroviral therapy
HIV: using antiretroviral therapy
Schistosomiasis
Pelvic and non-pelvic tuberculosis
Malaria
HIV: using antiretroviral therapy
AIDS
Diabetes
History of gestational diabetes
Diabetes: NIDDM and IDDM, non-vascular disease
Diabetes: with nephropathy, retinopathy, neuropathy, or other vascular disease
Thyroid
Simple goitre, hypothyroid, hyperthyroid
Haematological conditions
Anaemias: thalassaemia, iron deficiency, sickle cell disease
Dyslipidaemia
Known hyperlipidaemias
Antiretroviral therapy drug interactions (and consistent use of condoms is recommended)
DMPA with nucleoside reverse transcriptase inhibitors
DMPA with non-nucleoside reverse transcriptase inhibitors
DMPA with ritonavir-boosted protease inhibitors
NET-EN wit nucleoside reverse transcriptase inhibitors
NET-EN with non-nucleoside reverse transcriptase inhibitors
NET-EN with ritonavir-boosted protease inhibitors
Anticonvulsant therapy drug interactions (and consistent use of condoms is recommended)
DMPA with certain anticonvulsants (phenytoin, carbamazepine, barbiturates, primidone, topiramate, oxcarbazepine)
DMPA and NET-EN with lamotrigine
NET-EN with certain anticonvulsants (phenytoin, carbamazepine, barbiturates, primidone, topiramate, oxcarbazepine)
Antimicrobial therapy drug interactions (and consistent use of condoms is recommended)
DMPA and NET-EN with broad spectrum antibiotics, antifungals, antiparasitics.
DMPA with rifampicin or rifabutin
NET-EN with rifampicin or rifabutin†
BMI = body mass index; CIN = cervical intraepithelial neoplasia; DMPA = depot medroxyprogesterone acetate; hCG = human chorionic gonadotrophin; IDDM = insulin-dependent diabetes; NET-EN = norethisterone acetate; NIDDM = non-insulin-dependent diabetes; STI = sexually transmitted infection; SLE = systemic lupus erythematosus; TIA = transient ischaemic attack; VTE = venous thromboembolism.
† The consistent use of condoms is recommended, as antiretroviral drugs may reduce the effectiveness of hormonal contraceptives. Similarly, the interaction of certain anticonvulsants, rifampicin or rifabutin, with NET-EN is likely to reduce the effectiveness of NET-EN. The effectiveness of DMPA is not likely to be decreased by certain anticonvulsants, rifampicin or rifabutin.
Adapted from: [FSRH, 2009b]

UK Medical Eligibility Criteria for use of progestogen-only implants

The UK Medical Eligibility Criteria are a set of evidence-based recommendations designed to help women select the most appropriate method of contraception for specific clinical conditions without imposing necessary restrictions [FSRH, 2009b]. Each clinical condition has a recommendation for contraceptive use, categorized according to the balance of benefits and harms weighted by their probabilities for the typical user with the condition. The categories are defined in Table 1. Table 2 describes the UK Medical Eligibility Criteria for use of progestogen-only implants.

Table 1. UK Medical Eligibility Criteria (UKMEC).
Category
Definition
UKMEC 1
A condition for which there is no restriction for the use of the contraceptive method.
UKMEC 2
A condition where the advantages of using the method generally outweigh the theoretical or proven risks.
UKMEC 3
A condition where the theoretical or proven risks usually outweigh the advantages of using the method.
Provision of a method to a woman with a condition given a UKMEC Category 3 requires expert clinical judgement and/or referral to a specialist contraceptive provider since use of the method is not usually recommended unless other methods are not available or not acceptable.
UKMEC 4
A condition which represents an unacceptable health risk if the contraceptive method is used.
Source: [FSRH, 2009b]
Table 2. UK Medical Eligibility Criteria (UKMEC) for use of progestogen-only implants.
Clinical feature
UKMEC 1
No restrictions
UKMEC 2
Advantages generally outweigh risks
UKMEC 3
Requires expert clinical judgement
UKMEC 4
Contraindicated
Age
Menarche to menopause
Parity
Nulliparous
Parous
Breastfeeding
At any time
Postpartum, not breastfeeding
At any time
(although contraception is not necessary until 21 days after delivery)
Post-abortion
First- and second-trimester abortion
Immediately after septic abortion
Ectopic pregnancy
History of ectopic pregnancy
Smoking
Past or current smoker
Obesity
BMI >= 30 kg/m2
Blood pressure
Adequately controlled hypertension
Consistently elevated blood pressure systolic >140 mmHg or diastolic >90 mmHg
History of high blood pressure during pregnancy
Vascular disease
Surgery
History of pelvic surgery
Major surgery without prolonged immobilization
Minor surgery without immobilization
Major surgery with prolonged immobilization
Other risk factors for venous thromboembolism
Family history of VTE in a first-degree relative
Immobility (unrelated to surgery), e.g. wheelchair use, debilitating illness
Varicose veins
Superficial thrombophlebitis
History of VTE
Current VTE (on anticoagulants)
Known thrombogenic mutations, e.g. Factor V Leiden, Prothrombin mutation, Protein S, Protein C, Antithrombin deficiencies
Raynaud's disease
Primary
Secondary without lupus anticoagulant
Secondary with lupus anticoagulant
Systemic lupus erythematosus
SLE alone
SLE with severe thrombocytopenia
Immunosuppressive treatment
Positive (or unknown) antiphospholipid antibodies
Headaches
For initiation and continuation
Non-migrainous headaches (mild or severe)
For initiation and continuation
Migraine headaches without aura (any age)
Migraine headaches with aura (any age)
Past history (>= 5 years ago) of migraine with aura (any age)
Epilepsy
Epilepsy
Psychological conditions
Depressive disorders
Breast disease
Benign breast disease or a family history of breast cancer
Undiagnosed mass
Carriers of known gene mutations associated with breast cancer (e.g. BRCA1)
History of breast cancer and no evidence of recurrence for 5 years
Current breast cancer
Vaginal bleeding
Irregular pattern (light or heavy bleeding), but not suspicious
Heavy or prolonged bleeding
Unexplained vaginal bleeding (before evaluation) suspicious for serious underlying condition
Other gynaecological conditions
Endometriosis
Benign ovarian tumours including cysts
Severe dysmenorrhoea
Gestational trophoblastic disease when hCG is normal, persistently elevated, or malignant disease
Cervical ectropion
CIN
Endometrial cancer
Ovarian cancer
Uterine fibroids with or without distortion of the uterine cavity
Cervical cancer (awaiting treatment)
Cardiovascular conditions
Valvular and congenital heart disease: uncomplicated
Valvular and congenital heart disease: complicated (e.g. by pulmonary hypertension, atrial fibrillation, or history of subacute bacterial endocarditis)
For initiation
Stroke including TIA
Current and history of ischaemic heart disease
For initiation and continuation
Multiple risk factors for arterial cardiovascular disease
For continuation
Stroke including TIA
Current and history of ischaemic heart disease
Gastrointestinal conditions
History of cholestasis: pregnancy-related
Inflammatory bowel disease
Cirrhosis: mild compensated disease
Viral hepatitis: acute or flare, carrier, or chronic disease
Gallbladder disease: asymptomatic, or treated, or current
History of cholestasis: related to combined oral contraceptive
Liver tumours: benign (focal nodular hyperplasia)
Cirrhosis: severe decompensated disease
Liver tumours: benign (hepatocellular adenoma) and malignant (hepatoma)
Infections
Pelvic inflammatory disease: current or past (assuming no risk factors for STIs)
STIs: chlamydia infection (symptomatic or asymptomatic)
STIs: current purulent cervicitis or gonorrhoea, vaginitis, or increased risk of STIs
HIV/AIDS: high risk of HIV
HIV: current infection not using antiretroviral therapy
HIV: current infection using antiretroviral therapy
Schistosomiasis
Pelvic and non-pelvic tuberculosis
Malaria
HIV: current infection using antiretroviral therapy
AIDS
Diabetes
History of gestational diabetes
NIDDM and IDDM, non-vascular disease
Diabetes with nephropathy, retinopathy, neuropathy; or other vascular disease
Thyroid
Simple goitre, hypothyroid, hyperthyroid
Haematological conditions
Anaemias: thalassaemia, iron deficiency, sickle cell disease
Dyslipidaemia
Known hyperlipidaemias
Antiretroviral therapy drug interactions (and consistent use of condoms is recommended)
Nucleoside reverse transcriptase inhibitors
Non-nucleoside reverse transcriptase inhibitors
Ritonavir-boosted protease inhibitors
Anticonvulsant therapy drug interactions (and consistent use of condoms is recommended)
Lamotrigine
Certain anticonvulsants (phenytoin, carbamazepine, barbiturates, primidone, topiramate, oxcarbazepine)
Antimicrobial therapy drug interactions (and consistent use of condoms is recommended)
Broad spectrum antibiotics
Antifungals
Antiparasitics
Rifampicin or rifabutin therapy
BMI = body mass index; CIN = cervical intraepithelial neoplasia; hCG = human chorionic gonadotrophin; IDDM = insulin-dependent diabetes; NIDDM = non-insulin-dependent diabetes; STI = sexually transmitted infection; SLE = systemic lupus erythematosus; TIA = transient ischaemic attack; VTE = venous thromboembolism.
† The consistent use of condoms is recommended, as antiretroviral drugs may reduce the effectiveness of hormonal contraceptives. Similarly, the interaction of certain anticonvulsants, rifampicin or rifabutin, with implants is likely to reduce the effectiveness of implants.
Adapted from: [FSRH, 2009b]

UK Medical Eligibility Criteria for use of intrauterine methods (copper intrauterine device and levonorgestrel-releasing intrauterine system)

UK Medical Eligibility Criteria for use of copper intrauterine devices

The UK Medical Eligibility Criteria are a set of evidence-based recommendations designed to help women select the most appropriate method of contraception for specific clinical conditions without imposing necessary restrictions [FSRH, 2009b]. Each clinical condition has a recommendation for contraceptive use, categorized according to the balance of benefits and harms weighted by their probabilities for the typical user with the condition. The categories are defined in Table 1. Table 2 describes the UK Medical Eligibility Criteria for use of a copper-bearing intrauterine device (IUD).

Table 1. UK Medical Eligibility Criteria (UKMEC).
Category
Definition
UKMEC 1
A condition for which there is no restriction for the use of the contraceptive method.
UKMEC 2
A condition where the advantages of using the method generally outweigh the theoretical or proven risks.
UKMEC 3
A condition where the theoretical or proven risks usually outweigh the advantages of using the method.
Provision of a method to a woman with a condition given a UKMEC Category 3 requires expert clinical judgement and/or referral to a specialist contraceptive provider since use of the method is not usually recommended unless other methods are not available or not acceptable.
UKMEC 4
A condition which represents an unacceptable health risk if the contraceptive method is used.
Source: [FSRH, 2009b]
Table 2. UK Medical Eligibility Criteria (UKMEC) for use of a copper intrauterine device (IUD).
Clinical feature
UKMEC 1
No restrictions
UKMEC 2
Advantages generally outweigh risks
UKMEC 3
Requires expert clinical judgement
UKMEC 4
Contraindicated
Pregnancy
Pregnancy
Age
>= 20 years
Menarche to < 20 years
Parity
Nulliparous
Parous
Postpartum, breastfeeding or non-breastfeeding, including post-Caesarean Section
>= 4 weeks
48 hours to < 4 weeks
Puerperal sepsis
Post-abortion
First-trimester abortion
Second-trimester abortion
Immediately after septic abortion
Ectopic pregnancy
History of ectopic pregnancy
Smoking
Past or current smoker
Obesity
BMI >= 30 kg/m2
Blood pressure
Adequately controlled hypertension
Consistently elevated blood pressure systolic >140 mmHg or diastolic >90 mmHg
Vascular disease
History of high blood pressure during pregnancy
Surgery
History of pelvic surgery
Major surgery with or without prolonged immobilization
Minor surgery without immobilization
Other risk factors for venous thromboembolism
History of VTE
Current VTE (on anticoagulants)
Family history of VTE in a first-degree relative
Immobility (unrelated to surgery), e.g. wheelchair use, debilitating illness
Known thrombogenic mutations, e.g. Factor V Leiden, Prothrombin mutation, Protein S, Protein C, Antithrombin deficiencies
Varicose veins
Superficial thrombophlebitis
Raynaud's disease
Primary
Secondary, with and without lupus anticoagulant
Systemic lupus erythematosus
SLE alone
Positive (or unknown) antiphospholipid antibodies
For continuation
Immunosuppressive treatment
For initiation
Immunosuppressive treatment
For continuation
Severe thrombocytopenia
For initiation
Severe thrombocytopenia
Headaches
Non-migrainous headaches (mild or severe)
Migraine headaches with or without aura, at any age
History (>= 5 years ago) of migraine with aura, at any age
Epilepsy
Epilepsy
Psychological conditions
Depressive disorders
Breast disease
Undiagnosed mass
Benign breast disease or a family history of breast cancer
Carriers of known gene mutations associated with breast cancer (e.g. BRCA1)
Current breast cancer
History of breast cancer and no evidence of recurrence for 5 years
Vaginal bleeding
Irregular without heavy bleeding
For initiation and continuation
Heavy or prolonged bleeding (regular and irregular patterns)
For continuation
Unexplained vaginal bleeding (before evaluation) suspicious for serious underlying condition
For initiation
Unexplained vaginal bleeding (before evaluation) suspicious for serious underlying condition
Other gynaecological conditions
Benign ovarian tumours including cysts
Gestational trophoblastic disease when hCG is decreasing or normal
Cervical ectropion
CIN
Uterine fibroids, without distortion of the uterine cavity
For initiation and continuation
Severe dysmenorrhoea
Endometriosis
Other abnormalities (including cervical stenosis or cervical lacerations) not distorting the uterine cavity or interfering with IUD insertion
For continuation
Cervical cancer, awaiting treatment
Endometrial cancer
Ovarian cancer
Uterine fibroids, with distortion of the uterine cavity
Distorted uterine cavity (any congenital or acquired uterine abnormality distorting the uterine cavity in a manner that is incompatible with IUD insertion)
For initiation and continuation
Gestational trophoblastic disease when hCG is persistently elevated or malignant disease
For initiation
Cervical cancer, awaiting treatment
Endometrial cancer
Ovarian cancer
Cardiovascular conditions
Current and history of ischaemic heart disease
Stroke including TIA
Multiple risk factors for arterial cardiovascular disease
Valvular and congenital heart disease: uncomplicated
Valvular and congenital heart disease: complicated (e.g. by pulmonary hypertension, atrial fibrillation, or history of subacute bacterial endocarditis)
Gastrointestinal conditions
History of cholestasis (related to pregnancy or combined oral contraceptive)
Gallbladder disease: asymptomatic, symptomatic treated by cholecystectomy, medically treated, or current
Cirrhosis: mild (compensated) or severe (decompensated)
Liver tumours: benign (focal nodular hyperplasia; hepatocellular adenoma) and malignant (hepatoma)
Inflammatory bowel disease
Infections
For initiation and continuation
Past pelvic inflammatory disease (with no risk factors for STIs)
Schistosomiasis
Non-pelvic tuberculosis
Malaria
Viral hepatitis: acute or flare, carrier or chronic disease
For continuation
Current pelvic inflammatory disease
Chlamydia (symptomatic and asymptomatic)
Current purulent cervicitis or gonorrhoea
For initiation and continuation
Other STIs (excluding HIV and hepatitis)
Vaginitis
Increased risk of STIs
High risk of HIV
HIV (not using antiretroviral therapy)
HIV (using antiretroviral therapy)
AIDS

HIV (using antiretroviral therapy)

For continuation

Known pelvic tuberculosis
For initiation
Current pelvic inflammatory disease
Chlamydia (symptomatic and asymptomatic)
Current purulent cervicitis or gonorrhoea
Known pelvic tuberculosis
Diabetes
History of gestational diabetes
NIDDM and IDDM, non-vascular disease
With nephropathy, retinopathy, or neuropathy; or other vascular disease
Thyroid
Simple goitre, hypothyroid, hyperthyroid
Haematological conditions
Anaemias: thalassaemia, iron deficiency, or sickle cell disease
Dyslipidaemia
Known hyperlipidaemias
Antiretroviral therapy drug interactions (and consistent use of condoms is recommended)
 
For initiation and continuation
Nucleoside reverse transcriptase inhibitors
Non-nucleoside reverse transcriptase inhibitors
Ritonavir-boosted protease inhibitors
For initiation
Nucleoside reverse transcriptase inhibitors
Non-nucleoside reverse transcriptase inhibitors
Ritonavir-boosted protease inhibitors
Anticonvulsant therapy drug interactions
Certain anticonvulsants (e.g. phenytoin, carbamazepine, barbiturates, primidone, topiramate, oxcarbazepine)
Lamotrigine
Antimicrobial therapy drug interactions
Broad spectrum antibiotics
Antifungals
Antiparasitics
Rifampicin or rifabutin therapy
BMI = body mass index; CIN = cervical intraepithelial neoplasia; hCG = human chorionic gonadotrophin; IDDM = insulin-dependent diabetes; IUD = intrauterine device; NIDDM = non-insulin-dependent diabetes; STI = sexually transmitted infection; SLE = systemic lupus erythematosus; TIA = transient ischaemic attack; VTE = venous thromboembolism.
† The consistent use of condoms is recommended for women with HIV or AIDs on antiretroviral therapy, to prevent HIV transmission.
‡ There is no known interaction between antiretroviral therapy and IUD use. However, AIDS is classified as Category 3 for insertion and Category 2 for continuation unless the woman is clinically well on antiretroviral therapy, in which case both insertion and continuation are classified as Category 2.
Adapted from: [FSRH, 2009b]

UK Medical Eligibility Criteria for use of the levonorgestrel-releasing intrauterine system

The UK Medical Eligibility Criteria are a set of evidence-based recommendations designed to help women select the most appropriate method of contraception for specific clinical conditions without imposing necessary restrictions [FSRH, 2009b]. Each clinical condition has a recommendation for contraceptive use, categorized according to the balance of benefits and harms weighted by their probabilities for the typical user with the condition. The categories are defined in Table 1. Table 2 describes the UK Medical Eligibility Criteria for use of the levonorgestrel-releasing intrauterine system.

Table 1. UK Medical Eligibility Criteria (UKMEC).
Category
Definition
UKMEC 1
A condition for which there is no restriction for the use of the contraceptive.
UKMEC 2
A condition where the advantages of using the method generally outweigh the theoretical or proven risks.
UKMEC 3
A condition where the theoretical or proven risks usually outweigh the advantages of using the method.
Provision of a method to a woman with a condition given a UKMEC Category 3 requires expert clinical judgement and/or referral to a specialist contraceptive provider since use of the method is not usually recommended unless other methods are not available or not acceptable.
UKMEC 4
A condition which represents an unacceptable health risk if the contraceptive method is used.
Source: [FSRH, 2007]
Table 2. UK Medical Eligibility Criteria (UKMEC) for use of the levonorgestrel-releasing intrauterine system (IUS).
Clinical feature
UKMEC 1
No restrictions
UKMEC 2
Advantages generally outweigh risks
UKMEC 3
Requires expert clinical judgement
UKMEC 4
Contraindicated
Pregnancy
Pregnancy
Age
>= 20 years
Menarche to < 20 years
Parity
Nulliparous
Parous
Postpartum, breastfeeding or non-breastfeeding; and including post-Caesarean Section
>= 4 weeks
48 hours to < 4 weeks
Puerperal sepsis
Post-abortion
First-trimester abortion
Second-trimester abortion
Immediately after septic abortion
Ectopic pregnancy
History of ectopic pregnancy
Smoking
Current or previous smoker
Obesity
BMI >= 30kg/m2
Blood pressure
Adequately controlled hypertension
Consistently elevated blood pressure systolic >140 mmHg or diastolic >90 mmHg
History of high blood pressure during pregnancy
Vascular disease
Surgery
History of pelvic surgery
Major surgery without prolonged immobilization
Minor surgery without immobilization
Major surgery with prolonged immobilization
Other risk factors for venous thromboembolism
Family history of VTE in a first degree relative
Immobility (unrelated to surgery), e.g. wheelchair use, debilitating illness
Varicose veins
Superficial thrombophlebitis
History of VTE
Current VTE (on anticoagulants)
Known thrombogenic mutations, e.g. Factor V Leiden, Prothrombin mutation, Protein S, Protein C, Antithrombin deficiencies
Raynaud's disease
Primary
Secondary without lupus anticoagulant
Secondary with lupus anticoagulant
Systemic lupus erythematosus
SLE alone
Severe thrombocytopenia
Immunosuppressive treatment
Positive (or unknown) antiphospholipid antibodies
Headaches
Non-migrainous headaches (mild or severe)
Migraine without aura (any age)
Migraine with aura (any age)
Past history (>= 5 years) of migraine with aura (any age)
Epilepsy
Epilepsy (see drug interactions section)
Psychological conditions
Depressive disorders
Breast disease
Benign breast disease or a family history of breast cancer
Undiagnosed mass
Carriers of known gene mutations associated with breast cancer (e.g. BRCA1)
History of breast cancer and no evidence of recurrence for 5 years
Current breast cancer
Vaginal bleeding
Initiation and continuation
Irregular without heavy bleeding
Initiation
Heavy or prolonged bleeding (regular and irregular patterns)
Continuation
Vaginal bleeding, suspicion for serious condition
Heavy or prolonged bleeding (regular and irregular patterns)
Initiation
Unexplained vaginal bleeding (before evaluation) suspicious for serious underlying condition
Other gynaecological conditions
Initiation and continuation
Benign ovarian tumours, including cysts
Cervical ectropion
Uterine fibroids without distortion of the uterine cavity
Endometriosis
Severe dysmenorrhoea
Gestational trophoblastic disease when hCG is normal or decreasing
Continuation
Cervical cancer, awaiting treatment
Endometrial cancer
Ovarian cancer
Initiation and continuation
Other abnormalities (including cervical stenosis or cervical lacerations) not distorting the uterine cavity or interfering with IUS insertion
CIN
Uterine fibroids with distortion of the uterine cavity
Distorted uterine cavity (any congenital or acquired uterine abnormality distorting the uterine cavity in a manner that is incompatible with IUS insertion)
Initiation
Cervical cancer, awaiting treatment
Endometrial cancer
Ovarian cancer
Initiation and continuation
Gestational trophoblastic disease when hCG is persistently elevated or malignant disease
Cardiovascular conditions
Valvular and congenital heart disease: uncomplicated
Initiation
Current and history of ischaemic heart disease
Stroke including TIA
Initiation and continuation
Multiple risk factors for arterial cardiovascular disease
Valvular and congenital heart disease: complicated (e.g. by pulmonary hypertension, atrial fibrillation, or history of subacute bacterial endocarditis)
Continuation
Current and history of ischaemic heart disease
Stroke including TIA
Gastrointestinal conditions
History of cholestasis: pregnancy related
Cirrhosis, mild (compensated)
Inflammatory bowel disease
Gallbladder disease: asymptomatic, symptomatic treated by cholecystectomy, medically treated, or current
History of cholestasis: combined oral contraceptive related
Liver tumours: benign (focal nodular hyperplasia)
Cirrhosis, severe (decompensated)
Liver tumours: benign (hepatocellular adenoma)
Liver tumours: malignant (hepatoma)
Infections
For initiation and continuation
Past pelvic inflammatory disease (assuming no current risk factors for STIs)
Schistosomiasis
Non-pelvic tuberculosis
Malaria
Viral hepatitis: acute or flare, carrier or chronic
For initiation and continuation
Other STIs (excluding HIV and hepatitis)
Vaginitis
Increased risk of STIs
High risk of HIV
HIV, not using antiretroviral therapy
HIV, using antiretroviral therapy
AIDS
For continuation
Current pelvic inflammatory disease
Chlamydia (symptomatic or asymptomatic)
Current purulent cervicitis or gonorrhoea
For initiation and continuation
HIV, using antiretroviral therapy
For continuation
Known pelvic tuberculosis
For initiation
Current pelvic inflammatory disease
Chlamydia (symptomatic or asymptomatic)
Current purulent cervicitis or gonorrhoea
Known pelvic tuberculosis
Diabetes
History of gestational diabetes
NIDDM and IDDM, non-vascular disease
With nephropathy, retinopathy, neuropathy; or other vascular disease
Thyroid
Simple goitre, hypothyroid, hyperthyroid
Haematological conditions
Anaemias: thalassaemia, iron deficiency, sickle cell disease
Dyslipidaemia
Known hyperlipidaemias
Antiretroviral therapy drug interactions (and consistent use of condoms is recommended)
For initiation and continuation
Nucleoside reverse transcriptase inhibitors
Non-nucleoside reverse transcriptase inhibitors
Ritonavir-boosted protease inhibitors
For initiation
Nucleoside reverse transcriptase inhibitors
Non-nucleoside reverse transcriptase inhibitors
Ritonavir-boosted protease inhibitors
Anticonvulsant therapy drug interactions
Certain anticonvulsants (phenytoin, carbamazepine, barbiturates, primidone, topiramate, oxcarbazepine)
Lamotrigine
Antimicrobial therapy drug interactions
Broad spectrum antibiotics
Antifungals
Antiparasitics
Rifampicin or rifabutin therapy
BMI = body mass index; CIN = cervical intraepithelial neoplasia; hCG = human chorionic gonadotrophin; IDDM = insulin-dependent diabetes; IUD = intrauterine device; NIDDM = non-insulin-dependent diabetes; STI = sexually transmitted infection; SLE = Systemic lupus erythematosus; TIA = transient ischaemic attack; VTE = venous thromboembolism.
† The consistent use of condoms is recommended for women with HIV or AIDs on antiretroviral therapy, to prevent HIV transmission.
‡ AIDS is classified as Category 3 for insertion and Category 2 for continuation unless the woman is clinically well on antiretroviral therapy, in which case both insertion and continuation are classified as Category 2.
Adapted from: [FSRH, 2009b]

UK Medical Eligibility Criteria for use of barrier methods (male and female condoms, diaphragms and cervical caps)

The UK Medical Eligibility Criteria are a set of evidence-based recommendations designed to help women select the most appropriate method of contraception for specific clinical conditions without imposing necessary restrictions [FFPRHC, 2006a]. Each clinical condition has a recommendation for contraceptive use, categorized according to the balance of benefits and harms weighted by their probabilities for the typical user with the condition. The categories are defined in Table 1.

Table 1. UK Medical Eligibility Criteria (UKMEC).
Category
Definition
UKMEC 1
A condition for which there is no restriction for the use of the contraceptive method.
UKMEC 2
A condition where the advantages of using the method generally outweigh the theoretical or proven risks.
UKMEC 3
A condition where the theoretical or proven risks usually outweigh the advantages of using the method.
Provision of a method to a woman with a condition given a UKMEC Category 3 requires expert clinical judgement and/or referral to a specialist contraceptive provider since use of the method is not usually recommended unless other methods are not available or not acceptable.
UKMEC 4
A condition which represents an unacceptable health risk if the contraceptive method is used.
Source: [FFPRHC, 2006a]
  • The UK Medical Eligibility Criteria for male condoms:
    • All conditions are categorized as UKMEC 1 (no restriction), except for:
      • Latex sensitivity, which is categorized as UKMEC 3.
  • The UK Medical Eligibility Criteria for female condoms:
    • All conditions are categorized as UKMEC 1.
  • The UK Medical Eligibility Criteria for female barrier methods (diaphragm, cervical cap):
    • All conditions are categorized as UKMEC 1 (no restriction), except for:
      • Parity > 0, which is categorized as UKMEC 2.
      • Valvular and congenital heart disease, complicated (e.g. with pulmonary hypertension, atrial fibrillation, history of subacute bacterial endocarditis), which is categorized as UKMEC 2.
      • At high risk of HIV. or infected with HIV, or with AIDS, which are categorized as UKMEC 3.
      • History of toxic shock syndrome,, which is categorized as UKMEC 3.
      • Urinary tract infection, which is categorized as UKMEC 2.
      • Latex sensitivity, which is categorized as UKMEC 3.

UK Medical Eligibility Criteria for sterilization

UK Medical Eligibility Criteria for female sterilization

The UK Medical Eligibility Criteria are a set of evidence-based recommendations designed to help women select the most appropriate method of contraception for specific clinical conditions without imposing necessary restrictions [FFPRHC, 2006a]. Each clinical condition has a recommendation for contraceptive use, categorized according to the balance of benefits and harms weighted by their probabilities for the typical user with the condition. The categories are defined in Table 1. Table 2 describes the UK Medical Eligibility Criteria for female sterilization.

Table 1. UK Medical Eligibility Criteria (UKMEC).
Category
Definition
UKMEC Accept
There is no medical reason to deny sterilization to a person with this condition.
UKMEC Caution
The procedure is normally conducted in a routine setting, but with extra preparation, precautions, and counselling.
UKMEC Delay
The procedure is delayed until the condition is evaluated, treated, and/or changes. Alternative temporary methods of contraception should be provided.
UKMEC Special
The procedure should be undertaken in a setting with an experienced surgeon and staff, equipment needed to provide general anaesthesia, and other back-up medical support. For these conditions, the capacity to decide on the most appropriate procedure and anaesthesia method is also needed. Alternative temporary methods of contraception should be provided, if referral is required or there is otherwise any delay.
Source: [FFPRHC, 2006a]
Table 2. UK Medical Eligibility Criteria (UKMEC) for female sterilization.
Clinical feature
UKMEC Accept
No restrictions
UKMEC Caution
Additional preparation
UKMEC Delay
Evaluate, treat or observe
UKMEC Special
Specialized staff and facilities required
Pregnancy
Pregnancy
Age
Young age (particularly < 30 years)
Parity
Parous
Nulliparous
Postpartum
Breastfeeding
At the time of caesarean section
After vaginal delivery or emergency Caesarean section
Post-abortion
Post-abortion (spontaneous and induced)
Ectopic pregnancy
History of ectopic pregnancy
Smoking
Previous or current smoker
Obesity
BMI >= 30kg/m2
Blood pressure
History of high blood pressure during pregnancy
Adequately controlled hypertension
Consistently elevated blood pressure: systolic > 140–159 mmHg or diastolic > 90–94 mmHg
Consistently elevated blood pressure: systolic >= 160 mmHg, or diastolic >= 95 mmHg
Vascular disease including angina, intermittent claudication, hypertensive retinopathy, transient ischaemic attacks
Surgery
History of pelvic surgery
Major surgery without prolonged immobilization
Minor surgery without immobilization
Sterilization concurrent with abdominal surgery: elective
Major surgery with prolonged immobilization
Sterilization concurrent with abdominal surgery: emergency without previous counselling
Sterilization concurrent with abdominal surgery and with an infectious condition
Previous abdominal or pelvic surgery
Other risk factors for venous thromboembolism
History of VTE
Family history of VTE in a first-degree relative
Known thrombogenic mutations, e.g. factor V Leiden, prothrombin mutation, protein S, protein C, antithrombin deficiencies
Varicose veins
Superficial thrombophlebitis
Current VTE (on anticoagulants)
Immobility (unrelated to surgery), e.g. wheelchair use, debilitating illness
Coagulation disorders
Raynaud's disease
Primary
Secondary, with and without lupus anticoagulant
Headaches
Non-migrainous headaches; mild or severe
Migraine headaches with or without aura
History of migraine with aura at any age
Epilepsy
Epilepsy
Psychological conditions
Depressive disorders
Breast disease
Undiagnosed mass
Benign breast disease or a family history of breast cancer
Carriers of known gene mutations associated with breast cancer (e.g. BRCA1)
History of breast cancer and no evidence of recurrence for 5 years
Current breast cancer
Vaginal bleeding
Irregular, heavy, or prolonged bleeding
Unexplained vaginal bleeding (before evaluation), suspicious for serious condition
Other gynaecological conditions
Benign ovarian tumours, including cysts
Severe dysmenorrhoea
Gestational trophoblastic neoplasia when hCG is normal
Cervical ectropion
Cervical intraepithelial neoplasia (CIN)
Uterine fibroids, with or without distortion of the uterine cavity
Ovarian cancer
Gestational trophoblastic neoplasia when hCG is abnormal
Cervical cancer, awaiting treatment
Endometrial cancer
Endometriosis
Fixed uterus due to previous surgery or infection
Cardiovascular conditions
History of ischaemic heart disease
Stroke
Uncomplicated valvular and congenital heart disease
Current ischaemic heart disease
Multiple risk factors for arterial cardiovascular disease
Valvular and congenital heart disease complicated (e.g. by pulmonary hypertension, atrial fibrillation, or history of subacute bacterial endocarditis)
Gastrointestinal conditions
History of cholestasis: related to pregnancy or to use of combined oral contraceptive
Gallbladder disease: symptomatic treated by cholecystectomy, or medically treated
Asymptomatic gall bladder disease
Viral hepatitis: carrier
Cirrhosis: mild (compensated)
Liver tumours: benign and malignant
Gall-bladder disease: current symptomatic
Viral hepatitis: active
Cirrhosis: severe (decompensated)
Inflammatory bowel disease
Hernia
Diaphragmatic hernia
Abdominal wall or umbilical hernia
Infections
Past pelvic inflammatory disease (assuming no known current risk factors for STIs) with subsequent pregnancy
Schistosomiasis, uncomplicated
Non-pelvic tuberculosis
Malaria
Other STIs (excluding HIV and hepatitis)
Increased risk of STI's
Vaginitis
High risk of HIV or HIV-infected
Viral hepatitis: carrier
Past pelvic inflammatory disease (assuming no known current risk factors for STIs) without subsequent pregnancy
Schistosomiasis, with fibrosis of liver
Current purulent cervicitis or chlamydial infection or gonorrhoea
Current pelvic inflammatory disease
Local infection (abdominal skin infection)
Systemic infection
Gastroenteritis
Viral hepatitis: active
AIDS and using HAART
Known pelvic tuberculosis
Diabetes
History of gestational disease
NIDDM and IDDM, non-vascular disease
With nephropathy, retinopathy, or neuropathy, or other vascular disease
Other vascular disease
Duration > 20 years
Thyroid
Simple goitre
Hypothyroid
Hyperthyroid
Haematological conditions
Thalassaemia
Sickle cell disease
Iron-deficiency anaemia: haemoglobin level 7–10 g/dL
Iron-deficiency anaemia: haemoglobin level < 7 g/dL
Dyslipidaemia
Known hyperlipidaemias
Respiratory diseases
Acute bronchitis orpneumonia
Chronic asthma, bronchitis, emphysema, lung infection
Severe nutritional deficiencies
Severe nutritional deficiencies
Kidney disease
Kidney disease
BMI = body mass index; CIN = cervical intraepithelial neoplasia; HAART = highly active antiretroviral therapy; hCG = human chorionic gonadotrophin; IDDM = insulin-dependent diabetes; NIDDM = non-insulin-dependent diabetes; STI = sexually transmitted infection; VTE = venous thromboembolism.
Adapted from: [FFPRHC, 2006a]

UK Medical Eligibility Criteria for male sterilization

The UK Medical Eligibility Criteria are a set of evidence-based recommendations designed to help women and their partners select the most appropriate method of contraception for specific clinical conditions without imposing necessary restrictions [FFPRHC, 2006a]. Each clinical condition has a recommendation for contraceptive use, categorized according to the balance of benefits and harms weighted by their probabilities for the typical user with the condition. The categories are defined in Table 1. Table 2 describes the UK Medical Eligibility Criteria for male sterilization.

Table 1. UK Medical Eligibility Criteria (UKMEC).
Category
Definition
UKMEC Accept
There is no medical reason to deny sterilization to a person with this condition.
UKMEC Caution
The procedure is normally conducted in a routine setting, but with extra preparation, precautions, and counselling.
UKMEC Delay
The procedure is delayed until the condition is evaluated, treated, and/or changes. Alternative temporary methods of contraception should be provided.
UKMEC Special
The procedure should be undertaken in a setting with an experienced surgeon and staff, equipment needed to provide general anaesthesia, and other back-up medical support. For these conditions, the capacity to decide on the most appropriate procedure and anaesthesia method is also needed. Alternative temporary methods of contraception should be provided, if referral is required or there is otherwise any delay.
Source: [FFPRHC, 2006a]
Table 2. UK Medical Eligibility Criteria (UKMEC) for male sterilization.
Clinical feature
UKMEC Accept
No restrictions
UKMEC Caution
Additional preparation
UKMEC Delay
Evaluate, treat, or observe
UKMEC Special
Specialized staff and facilities required
Age
Young age (particularly < 30 years)
No offspring
No offspring
Psychological conditions
Depressive disorders
Infections
High risk of HIV, or HIV-infected
Local infections: scrotal skin infection, active STI, balanitis, epididymitis, or orchitis
Systemic infection or gastroenteritis
AIDS
Diabetes
Diabetes
Haematological conditions
Sickle-cell disease
Coagulation disorders
Injuries and surgical conditions
Previous scrotal injury
Large varicocele
Large hydrocele
Cryptorchidism*
Filariasis, elephantiasis
Intrascrotal mass
Inguinal hernia
Cryptorchidism*
* If cryptorchidism is bilateral and fertility has been demonstrated, extensive surgery will be required to locate the vas, and the procedure becomes category S. If the cryptorchidism is unilateral and fertility has been demonstrated, vasectomy may be performed on the normal side and semen analysis performed, as per routine. If the man continues to have a persistent presence of sperm, more extensive surgery may be required to locate the other vas, and the procedure becomes category S.
STI = sexually transmitted infection.
Adapted from: [FFPRHC, 2006a]

UK Medical Eligibility Criteria for use of natural methods (fertility awareness-based methods, lactational amenorrhoea method)

UK Medical Eligibility Criteria for use of fertility awareness-based methods

  • The UK Medical Eligibility Criteria are a set of evidence-based recommendations designed to help women select the most appropriate method of contraception for specific clinical conditions without imposing necessary restrictions [FFPRHC, 2006a].
  • There are no medical conditions which become worse due to the use of fertility awareness–based methods. In general, these methods can be provided without concern. However, several conditions make their use more complex. With some conditions, the woman requires special counselling by a more highly trained provider; with other conditions, use of a fertility awareness–based method should be delayed until the condition has resolved. Table 2 lists the conditions that make use of a fertility awareness–based method more complex. These conditions are placed into categories of Accept, Caution, and Delay, which are defined in Table 1.
  • Women with conditions which make pregnancy an unacceptable risk should be advised that fertility awareness–based methods may not be appropriate for them because of other methods have lower failure rates with typical use.
Table 1. UK Medical Eligibility Criteria (UKMEC) for fertility awareness–based methods.
Category
Definition
UKMEC Accept
There is no medical reason to deny the method to a woman in this circumstance.
UKMEC Caution
The procedure is normally conducted in a routine setting, but with extra preparation and precautions. For fertility awareness–based methods, this usually means that special counselling may be needed to ensure correct use of the method by a woman in this circumstance.
UKMEC Delay
Use of this method should be delayed until the condition is evaluated or corrected. Alternative temporary methods of contraception should be offered.
Source: [FFPRHC, 2006a]
Table 2. UK Medical Eligibility Criteria (UKMEC) for use of cervical mucus fertility awareness–based method.
Clinical feature
UKMEC Accept
No restrictions
UKMEC Caution
Special counselling required
UKMEC Delay
Delay until condition has resolved.
Offer alternative method.
Lifestage
In the first 2 years post-menarche
Perimenopause
Breastfeeding
 
>= 6 weeks
After menses begin
< 6 weeks postpartum
Postpartum, and not breastfeeding
>= 4 weeks
< 4 weeks
Post-abortion
Post-abortion
Vaginal bleeding
Irregular vaginal bleeding
Vaginal discharge
Vaginal discharge
Drugs
Use of drugs* which affect hormones, fertility signs, and/or the regularity of the menstrual cycle
* Certain mood-altering drugs, such as lithium, tricyclic antidepressants, and anti-anxiety therapies, as well as certain antibiotics and anti-inflammatory drugs, may alter cycle regularity or affect fertility signs.
Adapted from: [FFPRHC, 2006a]

UK Medical Eligibility Criteria for use of the lactational amenorrhoea method

  • The UK Medical Eligibility Criteria are a set of evidence-based recommendations designed to help women select the most appropriate method of contraception for specific clinical conditions without imposing necessary restrictions [FFPRHC, 2006a].
  • The conditions under which breastfeeding can be used safely and effectively for birth-spacing purposes, include the following three criteria, all of which must be met:
    • Amenorrhoea.
    • Fully or nearly fully breastfeeding. Full breastfeeding includes:
      • Exclusive breastfeeding — no other liquids or solids given.
      • Almost exclusive breastfeeding — vitamins, water, or juice given infrequently in addition to breastfeeds.
    • < 6 months postpartum.
  • Partial breastfeeding, even if the vast majority of feeds are breastfeeds, offers little protection against conception.
  • The main indications for breastfeeding remain the need to provide an ideal food for the infant and to protect it against disease.
  • There are no medical conditions in which the use of lactational amenorrhoea is restricted, and there is no documented evidence of its negative impact on maternal health. However, where pregnancy is an unacceptable risk, or where breastfeeding is contraindicated, other methods should be considered in preference.
  • Certain conditions or obstacles which affect breastfeeding may also affect the duration of amenorrhoea, making the lactational amenorrhoea method a less useful choice for family planning purposes. These include:
    • HIV infection. When replacement feeding is acceptable, feasible, affordable, sustainable, and safe, avoidance of all breastfeeding by HIV-infected mothers is recommended.
    • Medication used during breastfeeding. In order to protect the infant's health, breastfeeding is not recommended for women using such drugs as: anti-metabolites, bromocriptine, certain anticoagulants, corticosteroids (high doses), ciclosporin, ergotamine, lithium, mood-altering drugs, radioactive drugs, and reserpine.
    • Conditions affecting the newborn. Congenital deformities of the mouth, jaw, or palate; newborns who are in intensive neonatal care; and certain metabolic disorders of the infant all can make breastfeeding difficult or contraindicated.
  • The lactational amenorrhoea method does not protect against sexually transmitted infections, including HIV:
    • If the woman is at risk for sexually transmitted infection or HIV (including during pregnancy and postpartum), recommend correct and consistent use of condoms, either alone or with another contraceptive method.

© NHS Institute for Innovation and Improvement