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Croup - Management
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How should I assess someone with croup?
Assess the severity of the symptoms:
- Mild:
- Occasional barking cough and no audible stridor at rest.
- No or mild suprasternal and/or intercostal recession.
- The child is happy and is prepared to eat, drink, and play.
- Moderate:
- Frequent barking cough and easily audible stridor at rest.
- Suprasternal and sternal wall retraction at rest.
- No or little distress or agitation.
- The child can be placated and is interested in its surroundings.
- Severe:
- Frequent barking cough with prominent inspiratory (and occasionally, expiratory) stridor at rest.
- Marked sternal wall retractions.
- Significant distress and agitation, or lethargy or restlessness (a sign of hypoxaemia).
- Tachycardia occurs with more severe obstructive symptoms and hypoxaemia.
- Impending respiratory failure may develop regardless of the severity of the symptoms:
- The presence of any of these signs overrides any other clinical signs:
- Change in mental state, such as lethargy and listlessness or decreased level of consciousness.
- Pallor.
- Dusky appearance.
- Tachycardia.
- In children with impending respiratory failure, breathing may be laboured, a barking cough may not be prominent, stridor at rest may be hard to hear, and sternal wall retractions may not be marked.
- A child who appears to be deteriorating but whose stridor appears to be improving has worsening airways obstruction and is at high risk of complete airway occlusion.
Basis for recommendation
Who should I admit?
- Rarely, serious diseases may present with respiratory distress and stridor. Arrange immediate admission to hospital if you suspect a serious disorder:
- Caused by infection: epiglottitis, bacterial tracheitis, peritonsillar abscess, retropharyngeal abscess, or laryngeal diphtheria.
- Not caused by infection: foreign body, angioneurotic oedema, hypocalcaemic tetany, or ingestion of corrosives.
- Immediately admit a child who has moderate or severe croup, or impending respiratory failure.
- Most children will have mild croup, which can be managed at home. However, consider admission to hospital if any of the following are present. The child:
- Has a history of severe obstruction, or previous severe croup, or known structural upper airways abnormalities (e.g. laryngomalacia, tracheomalacia, vascular ring, Down's syndrome); these increase the risk of severe croup developing.
- Is less than 6 months of age.
- Is immunocompromised.
- Has inadequate fluid intake, or is refusing liquids.
- Has a poor response to initial treatment.
- Has an uncertain diagnosis.
- Or if there is significant parental anxiety, late evening or night-time presentation, the child's home is a long way from the hospital, or the parents have no transport.
Basis for recommendation
- The recommendations regarding assessment of severity and admission are based on expert opinion in guidelines [Alberta Medical Association, 2008], review articles [Cherry, 2005; Brown, 2006; Fitzgerald, 2006; Bjornson and Johnson, 2008], clinical practice guidelines [Sydney West Area Health Service, 2004], and a text book [Helms and Henderson, 2003]. The most important issue is the maintenance of the airway — if there is any risk of the child developing acute obstruction then they must be admitted to hospital urgently [Brown, 2006].
- There is little evidence to guide clinicians about which children should be admitted to hospital. A study of children (n = 527) admitted to hospital with stridor and/or sternal retractions at rest showed that only 1% of those who had resting stridor but no sternal retraction (n = 305) had worsening respiratory distress after admission [Wagener et al, 1986].
- A child with croup may be pyrexial but should not drool or be toxic (pale, very febrile, and poorly perfused) [Fitzgerald, 2006], and agitation is usually absent in croup [Brown and Klassen, 2000].
How should I treat a child with croup?
- Give all children with mild, moderate, or severe croup a single dose of oral dexamethasone (0.15 mg per kg body weight). If it is not possible to weigh the child then as a rough guide the dose would be 1.5–2 mg for a child of average size aged 12–15 months and 2–3 mg for a child of average size aged 3–4 years.
- Providers of urgent care services should ensure that dexamethasone is available.
- Oral prednisolone (1–2 mg per kg body weight) is an alternative if dexamethasone is not available. Consider giving a second dose if residual symptoms of stridor are still present the following day.
Basis for recommendation
- There is good evidence from a Cochrane systematic review that corticosteroids are beneficial in children with mild, moderate, and severe croup.
- Oral administration of dexamethasone is preferred, as there is evidence that it is at least as effective as intramuscular dexamethasone or nebulized budesonide, and oral administration is less traumatic for the child. Although there are no published trials comparing single- and multiple-dose regimens of dexamethasone in croup, the short history of the disease suggests that a single dose should be sufficient [Bjornson and Johnson, 2008].
- There is conflicting evidence regarding whether prednisolone is as effective as dexamethasone. Oral dexamethasone may reduce the need for additional medical attention compared to prednisolone. Expert reviewers suggested a repeat dose of prednisolone the following day particularly if there are any residual symptoms of stridor.
- CKS has recommended the use of the lower dose (0.15 mg per kg) of dexamethasone. A dose of 0.6 mg per kg has been used traditionally and there is more evidence for the use of this dose (e.g. 12 of the 31 trials [n = 2032] in a Cochrane review used this dose [Russell et al, 2004]). However evidence from four randomized controlled trials showed no difference in primary outcome measures between doses of 0.15 mg per kg body weight, and 0.6 mg per kg body weight. Advice from the British National Formulary (BNF) and expert opinion is that a dose of 0.15 mg per kg body weight is sufficient. The BNF recommends using a dose of 0.15 mg per kg in children with mild croup and also giving this dose to children who are being admitted to hospital [BNF 55, 2008].
- If prednisolone is used the BNF recommends a dose of 1–2 mg per kg body weight [BNF 55, 2008].
- Although steroid treatment of children with croup is generally well tolerated, concerns exist about possible adverse events. There are limited data on harms because of the small sample size in all available studies [Cherry, 2005], but no adverse effects have been associated with the use of corticosteroids in children with croup [Bjornson and Johnson, 2008].
What advice should I give to parents?
- Explain that croup is self limiting and symptoms usually resolve within 48 hours, although occasionally they may last for up to a week. Resolution of croup symptoms is usually followed by symptoms of upper respiratory tract infection.
- Advise the use of paracetamol or ibuprofen to control fever and pain:
- Do not over- or under-dress a child with fever.
- Tepid sponging is not recommended.
- Do not routinely give antipyretic drugs to a child with fever with the sole aim of reducing body temperature.
- Ensure an adequate fluid intake.
- Do not advise humidified air (e.g. steam inhalation).
- Arrange to review the child within a few hours, either by face-to-face consultation or by telephone. Advise parents to seek urgent medical advice:
- If there is progression from mild to moderate airways obstruction, such as development of intermittent stridor at rest or increased effort of breathing (chest and suprasternal indrawing), as the child may need to be observed in hospital.
- If the child becomes toxic (pale, very high fever, tachycardic) as this may mean the child has an alternative diagnosis (e.g. bacterial tracheitis or epiglottitis).
- Advise the parents to call for an emergency ambulance if the child:
- Becomes cyanosed.
- Is unusually sleepy.
- Is struggling to breathe.
- Explain that cough medicines, decongestants, and short-acting beta-agonists are not effective. Croup is usually a viral illness and antibiotics are not needed.
Basis for recommendation
- These recommendations are based on expert advice from the Alberta Medical Association guidelines [Alberta Medical Association, 2008], review articles [Fitzgerald, 2006; Vyas, 2007], and a text book [Brown and Klassen, 2000].
- The advice on managing fever is based on recommendations by the National Institute for Health and Clinical Excellence [NICE, 2007].
- Although there are no published controlled studies regarding the use of analgesics and antipyretics in children with croup, it is reasonable to suppose that they will reduce fever and pain [Alberta Medical Association, 2008].
- CKS found no evidence to support the use of humidified air in the treatment of croup; there is no benefit.
- CKS found no rationale for the use of cough medicines, decongestants, or short acting beta-agonists [Bjornson and Johnson, 2008].
- CKS found no controlled trials on the potential benefits of antibiotics in a child with croup; as croup is almost always a viral illness their use is not rational [Alberta Medical Association, 2008]. Superinfections, such as bacterial tracheitis and pneumonia, occur in less than 1/1000 children with croup and prophylactic antibiotics should not be used [Bjornson and Johnson, 2008].
Prescriptions
For information on contraindications, cautions, drug interactions, and adverse effects, see the electronic Medicines Compendium (eMC) (http://emc.medicines.org.uk), or the British National Formulary (BNF) (www.bnf.org).
Analgesia: use when required
Age from 3 to 5 months
Ibuprofen s/f susp: 50mg three times a day
Ibuprofen 100mg/5ml oral suspension sugar free
Take 2.5ml three times a day when required for pain relief. Do not exceed the stated dose.
Supply 50 ml.
Age from 3 to 11 months
Paracetamol s/f susp: 60mg to 120mg up to four times a day
Paracetamol 120mg/5ml oral suspension paediatric sugar free
Take 2.5ml to 5ml every 4 to 6 hours when required for pain relief. Maximum of 4 doses in 24 hours.
Supply 150 ml.
Age from 6 to 11 months
Ibuprofen s/f susp: 50mg three to four times a day
Ibuprofen 100mg/5ml oral suspension sugar free
Take 2.5ml three to four times a day when required for pain relief. Do not exceed the stated dose.
Supply 100 ml.
Age from 1 year to 3 years 11 months
Ibuprofen s/f susp: 100mg three times a day
Ibuprofen 100mg/5ml oral suspension sugar free
Take one 5ml spoonful three times a day when required for pain relief. Do not exceed the stated dose.
Supply 100 ml.
Age from 1 year to 5 years 11 months
Paracetamol s/f susp: 120mg to 240mg up to four times a day
Paracetamol 120mg/5ml oral suspension paediatric sugar free
Take one to two 5ml spoonfuls every 4 to 6 hours when required for pain relief. Maximum of 4 doses in 24 hours.
Supply 300 ml.
Age from 4 years to 5 years 11 months
Ibuprofen s/f susp: 150mg three times a day
Ibuprofen 100mg/5ml oral suspension sugar free
Take 7.5ml three times a day when required for pain relief. Do not exceed the stated dose.
Supply 150 ml.
Oral corticosteroid: dexamethasone or prednisolone
Age from 1 month to 5 years 11 months
Dexamethasone oral solution: 150micrograms per kg bodyweight
Dexamethasone 2mg/5ml oral solution sugar free
*WEIGHT REQUIRED* Give 150micrograms per kg bodyweight as a single dose.
Supply 30 ml.
Prednisolone soluble tablets: 1mg to 2mg per kg bodyweight
Prednisolone 5mg soluble tablets
*WEIGHT REQUIRED* Give 1 to 2 mg per kg bodyweight as a single dose.
Supply 10 tablets.
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