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Halitosis - Management
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How should I manage someone complaining of halitosis?

  • Refer all people with dental disease or suspected oral cancer.
  • Manage any underlying causes of halitosis.
  • If no pathological cause is identified:
    • Offer self-care advice about oral hygiene and advise the person to visit their dentist if oral or denture hygiene is poor.
      • Consider referring all people with halitosis (including those without a pathological cause) to a dentist for a full oral examination as some oral diseases may be difficult to diagnose by visual examination alone.
    • Give advice on reducing risk factors for halitosis.
      • Avoid foods and drinks known to cause transient halitosis — such as garlic, onion, and alcohol.
      • Advise smoking cessation and to avoid chewing tobacco (for further information, see the CKS topic on Smoking cessation).
      • Treat dry mouth by increasing fluid intake, sucking sugar-free sweets or chewing sugar-free gum. Consider the use of an artificial salivary substitute if these measures are insufficient.
      • Advise that dentures should be left out at night, and that the person consults their dentist if they have problems with their dentures.
    • Advise regular dental checks to ensure maintenance of oral hygiene.
    • Empirical treatment with antibiotics and Helicobacter pylori eradication therapy are not recommended.
  • For people without detectable halitosis:
    • Offer reassurance.
    • Suspect the possibility of pseudo-halitosis or halitophobia — particularly if they have good oral and dental health.
    • Discuss referral for psychological therapy if halitophobia is severe.
Basis for recommendation

These recommendations (including the management of people with suspected pseudo-halitosis or halitophobia) are based on published narrative reviews on halitosis or oral malodour [Rosenberg, 1996; Coventry et al, 2000; Morita and Wang, 2001; Messadi and Younai, 2003; Scully and Felix, 2005a; Porter and Scully, 2006; Lee et al, 2007; Hughes and McNab, 2008; Scully and Greenman, 2008; van den Broek et al, 2008].

Oral hygiene measures

  • The recommendation for oral hygiene measures is based on expert opinion and aims to reduce the accumulation of debris and bacteria in the mouth.

Referral to a dentist for people with halitosis

  • The recommendation to consider referring all people with halitosis (including people without pathological causes) is based on feedback from some CKS expert reviewers. This is because some oral diseases (such as periodontitis) may be difficult to diagnose by visual examination alone.

Treatments for halitosis that are not recommended

  • Empirical antibiotic treatment
    • In the absence of oral or dental infection, empirical antibiotic treatment (such as metronidazole 200 mg three times daily for 7 days) should only be initiated by a specialist; antibiotics may be used for recalcitrant cases of halitosis, to eliminate unidentified anaerobic infections [Coventry et al, 2000; Scully and Greenman, 2008].
  • Helicobacter pylori eradication
    • H. pylori has been implicated as a cause of halitosis, but the evidence for this is sparse [Scully and Felix, 2005a].
    • Although evidence from two very small trials reported improvement in halitosis following H. pylori eradication therapy in people with dyspepsia, these results should be interpreted with caution, given that [van den Broek et al, 2008]:
      • These trials generally did not examine the participants for oral causes of halitosis.
      • The reduction or disappearance of halitosis after eradication therapy could be due to the simultaneous eradication of halitosis-producing bacteria in the oral cavity.

What self-care advice should I offer someone with halitosis?

  • Explain that:
    • Transient bad breath is common upon waking (morning breath) and resolves with eating or drinking, or upon brushing the teeth or rinsing the mouth with water.
    • Persistent halitosis is commonly caused by accumulation of food debris and dental bacterial plaque on the teeth and tongue.
  • Give advice on general oral hygiene measures.
    • Brush teeth twice daily (particularly last thing at night).
    • Clean the interdental spaces using an appropriate aid (floss, tape, sticks, or single-tufted brush).
    • Reduce the frequency and amount of sugary food and drinks consumed. These should be limited to mealtimes and consumed not more than four times a day.
    • Advise the person to seek advice from a dentist or dental hygienist if they have problems maintaining dental hygiene (for example with brushing or using interdental aids).
    • Encourage regular dental checks to ensure maintenance of oral hygiene.
  • Recommend or prescribe a trial of an antibacterial mouthwash and/or toothpaste if the above oral hygiene measures are insufficient (see Additional information).
    • Improvement will indicate that the halitosis is related to oral hygiene.
  • Consider tongue brushing — particularly for people with halitosis who have good oral hygiene and health.
    • This can be done by gently brushing the surface of the tongue (in particularly the posterior region) with a soft headed toothbrush while brushing the teeth (with toothpaste). Although a proprietary tongue scraper can be considered, there is insufficient evidence to recommend one product over another.
    • Excessive scraping should be avoided as this can cause damage and bleeding to the tongue.
    • Care should be taken to avoid triggering the gagging reflex.
  • Explain that non-antibacterial products (such as mints, flavoured/perfumed mouth sprays/rinses, and chewing gums) only provide transient masking of halitosis. They are no substitute for good oral hygiene.
Additional information

Antibacterial toothpastes and mouthwashes

  • These preparations are widely available from supermarkets and pharmacies.
  • Antibacterial agents include cetylpyridinium chloride, chlorhexidine, hexetidine, hydrogen peroxide, and triclosan.
  • Given the lack of good evidence to support these products, the choice of preparation will depend on individual preference and product tolerability.
  • Of the mouthwashes, chlorhexidine gluconate 0.2% mouthwash is most commonly prescribed in primary care. However, some people may find it difficult to use chlorhexidine in the long term because [Porter and Scully, 2006]:
  • Some experts do not recommend the use of mouthwashes with a high alcohol content as this can cause a drying effect on the mouth [Morita and Wang, 2001]. Alcohol-free mouthwashes are available.
Basis for recommendation

These recommendations are mainly based on expert opinion published in narrative reviews on halitosis or oral malodour [Rosenberg, 1996; Coventry et al, 2000; Loesche and Kazor, 2002; Messadi and Younai, 2003; Scully and Felix, 2005a; Porter and Scully, 2006; Lee et al, 2007; Hughes and McNab, 2008; Scully and Greenman, 2008; van den Broek et al, 2008]. Evidence is lacking for treatments of halitosis (such as mouthwashes, tongue scraping, toothpaste, and interdental aids).

General hygiene measures

Antibacterial mouthwashes and toothpaste

  • The recommendation to offer antibacterial mouthwashes and/or toothpastes is based on expert opinion [Messadi and Younai, 2003; Porter and Scully, 2006; Scully and Greenman, 2008].
    • Although acknowledging that certain mouthwashes can be useful in reducing levels of halitosis-producing bacteria (for example chlorhexidine or cetylpyridinium chloride mouthwashes), a Cochrane systematic review found poor evidence to support their use [Fedorowicz et al, 2008].
    • CKS found a lack of good evidence for the various types of toothpastes (antibacterial and non-antibacterial) for the treatment of halitosis.
  • Consequently, CKS is unable to recommend a specific mouthwash or toothpaste for the management of halitosis.

Tongue scraping

  • A Cochrane systematic review found weak and unreliable evidence to support the use of tongue scraping for the management of halitosis [Outhouse et al, 2006].
  • Given that the back of the tongue is regarded as a major oral source of halitosis, the recommendation to consider tongue scraping is based on expert opinion — particularly in people with halitosis who have good dental hygiene [Rosenberg, 1996; Messadi and Younai, 2003; Quirynen, 2003; Porter and Scully, 2006].
  • Provided it is done gently and regularly, tongue scraping is regarded as not harmful, and may provide transient benefits in controlling halitosis [Porter and Scully, 2006].

When should I refer?

  • Urgently refer to an appropriate specialist, anyone with:
    • Acute necrotizing ulcerative gingivitis. See the section on Acute necrotizing ulcerative gingivitis in the CKS topic on Gingivitis and periodontitis.
    • Unexplained tooth mobility for more than 3 weeks.
    • Unexplained ulceration of the oral mucosa or mass persisting for more than 3 weeks.
    • Unexplained red and white patches (including suspected lichen planus) of the oral mucosa that are painful or swollen or bleeding.
    • Unexplained or atypical enlargement of the gingivae (possibly indicative of leukaemia).
  • Non-urgent referral to a dentist is required for people with:
    • Clinically-apparent gingivitis that is not responding to standard oral hygiene measures.
    • Periodontitis.
    • Unexplained red and white patches (including suspected lichen planus) of the oral mucosa that are not painful, swollen, or bleeding.
    • Poorly-fitted dentures.
    • Poor oral or denture hygiene.
  • Some experts recommend referring all people with halitosis (including those without pathological causes) to a dentist for a full oral examination, as some oral diseases (such as periodontitis) may be difficult to diagnose by visual examination alone.
  • Refer non-urgently to an ear nose and throat specialist people with the following conditions in whom an oral cause has been excluded:
    • Recurrent tonsillitis (see the CKS topic on Sore throat - acute).
    • Sinonasal disease such as septal deviation, and frequent recurrent sinusitis (see the CKS topic on Sinusitis).
  • For people with other persistent symptoms or signs related to the oral cavity in whom a definitive diagnosis of a benign lesion cannot be made, refer or follow up until the symptoms and signs disappear. If the symptoms and signs have not disappeared after 6 weeks, make an urgent referral.
Basis for recommendation

These recommendations are based on referral guidance issued by the National Institute for Health and Clinical Excellence for suspected cancer [NICE, 2005], expert opinion published in a narrative review [Porter and Scully, 2006], and feedback from CKS expert reviewers.

Referral to a dentist for people with halitosis

  • The recommendation to consider referring all people with halitosis (including people without pathological causes) to a dentist is based on feedback from some CKS expert reviewers. This is because some oral diseases (such as periodontitis) may be difficult to diagnose by visual examination alone.

Prescriptions

For information on contraindications, cautions, drug interactions, and adverse effects, see the electronic Medicines Compendium (eMC) (http://emc.medicines.org.uk), or the British National Formulary (BNF) (www.bnf.org).

Mouthwashes

Age from 12 years onwards
Chlorhexidine 0.2% mouthwash: rinse with 10ml twice a day
Chlorhexidine gluconate 0.2% mouthwash
Rinse the mouth with 10ml for about 1 minute twice a day.
Supply 300 ml.
Age: from 12 years onwards
NHS cost: £2.10
OTC cost: £3.70
Licensed use: yes
Patient information: When used regularly, this mouthwash may stain teeth brown but this is not usually permanent. Brushing the teeth before using the mouthwash can minimize the staining but make sure that you rinse your mouth well with water before you rinse with the mouthwash.
Chlorhexidine/Chlorobutanol mouthrinse: use 2-3 times a day
Chlorobutanol 0.5% / Chlorhexidine gluconate 0.1% mouthwash sugar free
Rinse the mouth with 10 to 15ml (diluted with lukewarm water, using the measuring cup provided) for about a minute two to three times a day.
Supply 250 ml.
Age: from 12 years onwards
NHS cost: £2.83
OTC cost: £4.65
Licensed use: yes
Patient information: When used regularly, this mouthwash may stain teeth brown but this is not usually permanent. Brushing the teeth before using the mouthwash can minimize the staining but make sure that you rinse your mouth well with water before you rinse with the mouthwash.
Hexetidine 0.1% mouthwash: use 15 ml two to three times a day
Hexetidine 0.1% mouthwash sugar free
Rinse the mouth with 15ml for about 1 minute two to three times a day.
Supply 200 ml.
Age: from 12 years onwards
NHS cost: £2.02
OTC cost: £3.32
Licensed use: yes
Hydrogen peroxide 6% (20 vol) mouthwash: use 2-3 times a day
Hydrogen peroxide 6% solution
Rinse the mouth with 15ml (diluted in half a glass of warm water) for about 2 minutes two to three times a day.
Supply 200 ml.
Age: from 12 years onwards
NHS cost: £0.43
OTC cost: £0.76
Licensed use: yes
Hydrogen peroxide 1.5% mouthwash: use up to 4 times a day
Hydrogen peroxide 1.5% mouthwash sugar free
Rinse the mouth with 10ml up to four times a day (after meals and at bedtime).
Supply 300 ml.
Age: from 12 years onwards
NHS cost: £2.95
OTC cost: £4.20
Licensed use: yes

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