Print Print
CKS is no longer commissioned by the National Institute for Health and Clinical Excellence (NICE). NICE remains committed to providing a replacement service for CKS and is currently reviewing its options. In the meantime, although CKS content is now not being maintained, it still remains relevant and will continue to be made available. CKS content was generated under a programme of topic creation and update. To check if the topic you are viewing is current or out of date, please refer to the topic publication details by clicking on the 'How up-to-date is this topic?' link in the left hand menu on individual topic pages.

Hypercalcaemia - Background information
What is it?

  • Hypercalcaemia can be defined as a serum calcium concentration of 2.65 mmol/L (or higher) on two occasions, following adjustment (correction) for the serum albumin concentration [Davies et al, 2002; Smellie et al, 2008].
  • Hypercalcaemia can be classified as mild, moderate, or severe based on adjusted serum calcium concentration. However, this does not necessarily reflect the severity of symptoms which are also dependent on the rate of onset of hypercalcaemia [Smellie et al, 2008].
    • Mild hypercalcaemia is an adjusted serum calcium concentration of 2.65–3.00 mmol/L.
    • Moderate hypercalcaemia is an adjusted serum calcium concentration of 3.01–3.40 mmol/L.
    • Severe hypercalcaemia is an adjusted serum calcium concentration of greater than 3.40 mmol/L.

© NHS Institute for Innovation and Improvement