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Immunizations - travel vaccinations - Management
What types of cholera vaccines are available?
- Oral inactivated cholera vaccine (Dukoral®) is the only licensed cholera vaccine available in the UK.
- Dukoral® protects against disease caused by Vibrio cholerae serogroup O1, and is licensed for use in adults and children over 2 years of age.
Basis for recommendation
- These recommendations are based on expert opinion from the medical literature [DH, 2006c].
- In clinical trials, three doses of vaccine demonstrated 85% protective efficacy (95% CI 56 to 94) at 6 months in children aged 2–15 years and in women over the age of 15 years. The protective efficacy of the vaccine when given to children aged 2–5 years waned rapidly so that, by 36 months after administration, the cumulative protective efficacy was 26%, compared with adults and children over the age of 5 years in whom it was 63% [DH, 2006c].
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