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Incontinence - urinary, in women - Management
View full scenario
What lifestyle advice should I give to a woman with stress urinary incontinence or urgency incontinence?
- Advise, and give information on, weight loss if the woman has a body mass index of 30 kg/m2 or greater (see the CKS topic on Obesity).
- Advise the woman to avoid drinking either excessive amounts, or small amounts, of fluid each day. The recommended daily intake is six to eight glasses of water (or other fluid).
- Although there is no evidence that modification of other behaviours improves incontinence symptoms, consider providing advice on regulating bowel habit, stopping smoking, or increasing physical exercise. Improving mobility may be helpful to disabled elderly women.
In depth
Should I recommend the use of absorbent pads or containment devices?
- Reserve the use of absorbent products for the following circumstances:
- To cope with urinary leakage whilst awaiting assessment and treatment.
- To contain leakage whilst awaiting response to ongoing treatment.
- For women with severe cognitive or mobility impairment that precludes further assessment or treatment.
- For long-term management only after all treatment options have been explored.
- If appropriate, refer to a continence adviser or the district nursing service to enable provision of the most suitable daytime and night-time protection (such as pads).
- If the woman is keen to purchase an intravaginal or intraurethral device, advise that they may only be used occasionally to prevent incontinence (such as during physical exercise).
- Do not recommend the use of menstrual tampons for incontinence.
- Ring pessaries are not recommended.
In depth
How should I manage a woman whose symptoms are predominantly of urgency incontinence associated with overactive bladder syndrome?
- Treat any conditions that may be causing or contributing to the symptoms, including:
- Lower urinary tract conditions (such as urinary tract infection).
- Neurological conditions (such as Parkinson's disease and multiple sclerosis).
- Systemic conditions (such as congestive heart failure and diabetes mellitus).
- Functional and behavioural disorders (such as impaired mobility and excess alcohol use).
- Adverse effects of medication (such as rapid-acting diuretics).
- Recommend caffeine reduction if appropriate.
- Refer women with an overactive bladder with or without urgency incontinence, and those with mixed urinary incontinence, to an appropriate practitioner for a full assessment and consideration of bladder training for a minimum of 6 weeks.
- If bladder training is ineffective, offer to add in immediate-release oxybutynin with upward dose titration from an initial low dose. Encourage the woman to persist with bladder training.
- If immediate-release oxybutynin is not tolerated, consider other antimuscarinic drugs (darifenacin, fesoterodine, solifenacin, tolterodine, and trospium) or an alternative formulation of oxybutynin (modified-release tablets or transdermal patches).
- If antimuscarinic drugs are prescribed:
- Counsel the person regarding the adverse effects of these drugs — particularly elderly people, who are more prone to the antimuscarinic adverse effects (see below).
- Review after 6 weeks' treatment to assess the balance between beneficial and adverse effects.
- If beneficial, review treatment after 6 months to assess whether it is still needed.
- Continue treatment for as long as benefit is maintained and the woman wishes for it to be continued.
- Consider:
- Propiverine to treat frequency in women with an overactive bladder without incontinence.
- Intravaginal oestrogen therapy (but not systemic hormone replacement therapy) with PFMT or other treatments in postmenopausal women with vaginal atrophy, urethral pain, or dysuria.
- Review at least annually to re-assess the need for continued treatment and to monitor for symptoms of endometrial hyperplasia or carcinoma in women with a uterus.
- Long-term treatment may be required. Consider seeking specialist advice if uncertain how long to prescribe intravaginal oestrogen therapy for.
- Desmopressin (unlicensed use) if the woman has troublesome nocturia and is younger than 65 years of age without cardiovascular disease. Advise restriction of night-time intake of fluid to reduce the risk of fluid retention and water intoxication. With desmopressin, measure serum sodium (particularly in elderly people and in people at risk of hyponatraemia):
- Before starting treatment.
- 72 hours after starting treatment.
- If unwell.
- If medications change.
- If hyponatraemia is suspected.
- If conservative measures fail, refer for urodynamic investigations and consideration of sacral nerve stimulation, treatment with botulinum toxin, or surgery. See Secondary care treatments for urgency incontinence.
- In frail elderly people:
- Take into account cognitive function, mobility, dexterity, desire for treatment, and expectation.
- Where appropriate, refer for a full assessment and consideration for bladder training.
- Review current medication. Consider adding an antimuscarinic; start at the lowest dose, as adverse effects, particularly confusion, are more common in elderly people. Be aware that antimuscarinic drugs may affect cognitive function in elderly people (particularly if cognitive impairment is already present — for example dementia) and monitor regularly for this.
- Refer where appropriate to a continence adviser, the district nursing team, or elderly care team for specialist assessment for the management of incontinence.
- For some women with urgency incontinence who have cognitive impairment, limited mobility, or both, the use of toilet-assisted protocols, such as prompted or timed voiding, can be helpful.
- The following treatments are not recommended:
- Propantheline, flavoxate, or imipramine.
- Diuretics. However, these are needed if there is nocturnal polyuria secondary to cardiac failure.
- Complementary therapies (acupuncture, hypnosis, herbal medicines).
In depth
Prescriptions
First line antimuscarinic
Age from 18 years onwards
Start oxybutynin tablets: 5mg two to three times a day
Oxybutynin 5mg tablets
Take one tablet two to three times a day.
Supply 56 tablets.
Age from 60 years onwards
Start oxybutynin tablets (elderly): 2.5mg twice a day
Oxybutynin 2.5mg tablets
Take one tablet twice a day.
Supply 56 tablets.
Start oxybutynin tablets (elderly): 3mg twice a day
Oxybutynin 3mg tablets
Take one tablet twice a day.
Supply 56 tablets.
Second line antimuscarinics (if oxybutynin not tolerated)
Age from 18 years onwards
Start oxybutynin m/r tablets: 5mg once a day
Oxybutynin 5mg modified-release tablets
Take one tablet once a day.
Supply 30 tablets.
Start oxybutynin patches: apply one patch twice a WEEK
Oxybutynin 3.9mg/24hours patches
Apply one patch twice a week.
Supply 8 patches.
Start darifenacin m/r tablets: 7.5mg once a day
Darifenacin 7.5mg modified-release tablets
Take one tablet once a day.
Supply 28 tablets.
Start fesoterodine m/r tablets: 4mg once a day
Fesoterodine 4mg modified-release tablets
Take one tablet once a day.
Supply 28 tablets.
Start solifenacin tablets: 5mg once a day
Solifenacin 5mg tablets
Take one tablet once a day.
Supply 28 tablets.
Start tolterodine tablets: 2mg twice a day
Tolterodine 2mg tablets
Take one tablet twice a day.
Supply 56 tablets.
Start trospium tablets: 20mg twice a day
Trospium chloride 20mg tablets
Take one tablet twice a day (on an empty stomach).
Supply 60 tablets.
Desmopressin (for troublesome nocturia)
Age from 16 to 65 years
Start desmopressin tablets: 200micrograms at bedtime
Desmopressin 200microgram tablets
Take one tablet at bedtime.
Supply 30 tablets.
Intravaginal oestrogens (postmenopausal women)
Age from 40 years onwards
Estriol 0.1% cream (500mcg estriol per application)
Ovestin 0.1% cream
Insert one applicatorful into the vagina each evening until improvement occurs. Then reduce to one applicatorful twice a week.
Supply 15 grams.
Estriol 500microgram pessaries
Ortho-Gynest 500microgram pessaries
Insert one pessary into the vagina each evening, until improvement occurs. Then reduce to one pessary twice a week.
Supply 30 pessaries.
Estradiol 25microgram m/r pessaries
Vagifem 25microgram vaginal tablets
Insert one pessary into the vagina each evening for 2 weeks, then reduce to one pessary twice a week.
Supply 30 pessaries.
Estradiol 2mg vaginal ring (7.5mcg estradiol/24 hours)
Estring 2mg vaginal ring
Insert one ring high into the vagina and wear continuously for 3 months.
Supply 1 vaginal ring.
Conjugated oestrogens 625micrograms/gram
Conjugated oestrogens 625micrograms/g vaginal cream
Insert 1-2 grams (using the applicator) into the vagina each evening for 3 weeks. Repeat after an interval of 1 week.
Supply 42 grams.
Propiverine (overactive bladder without incontinence)
Age from 18 years onwards
Propiverine tablets: 15mg up to three times a day
Propiverine 15mg tablets
Take one tablet up to three times a day, increased if necessary to four times a day.
Supply 84 tablets.
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