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Lipid modification - primary and secondary CVD prevention - Management
What are the licensed dosages for fibrates?
- Licensed dosages for fibrates licensed in the UK can be found in Table 1.
- Note: as fibrates are not licensed for the primary and secondary prevention of cardiovascular disease (with the exception of gemfibrozil for primary prevention in men), only licensed dosages are offered.
Table 1. Licensed dosages for fibrates licensed in the UK.
Bezafibrate | Ciprofibrate | Fenofibrate | Gemfibrozil |
|---|
Bezafibrate 200 mg tablets Dose: 200 mg three times a day | Ciprofibrate 100 mg tablets Dose: 100 mg daily | Fenofibrate 67 mg capsules (micronised) (Lipantil® Micro 67) Dose: 3 capsules taken daily in divided doses Usual range: 2–4 capsules daily | Gemfibrozil 300 mg capsules Usual dose: 900 mg to 1200 mg daily Note: the only dose with documented effect on morbidity is 1200 mg daily. The 1200 mg dose should be taken as 600 mg twice daily, half an hour before breakfast and half an hour before the evening meal. The 900 mg dose should be taken as a single dose half an hour before the evening meal. In people with mild or moderate renal impairment (glomerular filtration rate 50–80 and 30–50 mL/min/1.73 m2, respectively), start treatment at 900 mg daily and assess renal function before increasing dose. |
Bezafibrate 400 mg modified-release tablets Dose: 400 mg once daily | Fenofibrate 200 mg capsules (micronised) (Lipantil® Micro 200) Dose: 1 capsule daily |
Fenofibrate 267 mg capsules (micronised) (Lipantil® Micro 267) Dose: 1 capsule daily |
Fenofibrate 160 mg tablets (micronised) (Supralip®) Dose: 1 tablet daily (People taking 1 Lipantil Micro 200 mg capsule can be changed to 1 Supralip 160 mg tablet without further dose adjustment) |
Fenofibrate capsules (not micronised) (generic) Dose: 1 capsule daily (Actual product not available: Fenogal®) |
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