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Lipid modification - primary and secondary CVD prevention - Management
What is the mechanism of action of statins?
- Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, an enzyme involved in cholesterol synthesis. Inhibition of HMG CoA reductase reduces low-density lipoprotein (LDL) cholesterol levels by slowing down the production of cholesterol in the liver and increasing the liver's ability to remove the LDL cholesterol already in the blood [NICE, 2006].
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