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Lipid modification - primary and secondary CVD prevention - Management
Bile acid sequestrants - secondary prevention

Age from 18 years onwards
Colestyramine powder 4g sachets: dose titration
Colestyramine 4g oral powder sachets sugar free
Take the contents of one sachet (dissolved in water or a suitable liquid) once daily for the first week. Increase to two sachets daily in the second week and then to three sachets daily in the third week.
Supply 50 sachets.
Age: from 18 years onwards
NHS cost: £11.42
Licensed use: no - off-label indication
Patient information: Mix the powder in 150 ml of water or a suitable liquid (e.g. fruit juice, skimmed milk, thin soups, pulpy fruits with high moisture content, [e.g. apple sauce]) and stirred to a uniform consistency. Allow to stand for one or two minutes. After the powder becomes wetted, stir or shake to make a uniform suspension before administration. Colestyramine may be taken as a single daily dose or in divided doses up to four times daily. Colestyramine powder should not be taken in its dry form. Other drugs should be taken at least one hour before or 4-6 hours after taking colestyramine.
Colestyramine powder 4g sachets: 12g daily (maintenance)
Colestyramine 4g oral powder sachets sugar free
Take the contents of three sachets (dissolved in water or a suitable liquid) each day.
Supply 100 sachets.
Age: from 18 years onwards
NHS cost: £22.84
Licensed use: no - off-label indication
Patient information: Mix the powder in 150 ml of water or a suitable liquid (e.g. fruit juice, skimmed milk, thin soups, pulpy fruits with high moisture content, [e.g. apple sauce]) and stir to a uniform consistency. Allow to stand for one or two minutes. After the powder becomes wetted, stir or shake to make a uniform suspension before taking it. Colestyramine may be taken as a single daily dose or in divided doses up to four times a day. Colestyramine powder should not be taken in its dry form. Other drugs should be taken at least one hour before or 4-6 hours after taking colestyramine.
Colestyramine powder 4g sachets: 24g daily (maintenance)
Colestyramine 4g oral powder sachets sugar free
Take the contents of six sachets (dissolved in water or a suitable liquid) each day.
Supply 200 sachets.
Age: from 18 years onwards
NHS cost: £45.68
Licensed use: no - off-label indication
Patient information: Mix the powder in 150 ml of water or a suitable liquid (e.g. fruit juice, skimmed milk, thin soups, pulpy fruits with high moisture content, [e.g. apple sauce]) and stirred to a uniform consistency. Allow to stand for one or two minutes. After the powder becomes wetted, stir or shake to make a uniform suspension before administration. Colestyramine may be taken as a single daily dose or in divided doses up to four times daily. Colestyramine powder should not be taken in its dry form. Other drugs should be taken at least one hour before or 4-6 hours after taking colestyramine.
Colestipol 5g sachets: 5g daily
Colestipol 5g granules sachets sugar free
Take the contents of one sachet (dissolved in water or a suitable liquid) once a day.
Supply 30 sachets.
Age: from 18 years onwards
NHS cost: £15.05
Licensed use: no - off-label indication
Patient information: Mix the granules in 100 ml or more of a suitable liquid (e.g. orange or tomato juice, water, skimmed milk or non-carbonated beverage) until dispersed. The granules may also be taken in soups or with cereals, pulpy fruits with a high water content or yoghurt. Other drugs should be taken at least one hour before or 4-6 hours after taking colestipol.
Colestipol 5g sachets: 10g daily
Colestipol 5g granules sachets sugar free
Take the contents of two sachets (dissolved in water or a suitable liquid) once a day.
Supply 60 sachets.
Age: from 18 years onwards
NHS cost: £30.10
Licensed use: no - off-label indication
Patient information: Mix the granules in 100 ml or more of a suitable liquid (e.g. orange or tomato juice, water, skimmed milk or non-carbonated beverage) until dispersed. The granules may also be taken in soups or with cereals, pulpy fruits with a high water content or yoghurt. Other drugs should be taken at least one hour before or 4-6 hours after taking colestipol.
Colesevelam tablets: 3.75g daily
Colesevelam 625mg tablets
Take six tablets daily in one or two divided doses.
Supply 180 tablets.
Age: from 18 years onwards
NHS cost: £92.66
Licensed use: no - off-label indication
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Patient information: Take the tablets with a meal and liquid. Other drugs should be taken at least one hour before or 4-6 hours after taking colesevelam.

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