Print Print
CKS is no longer commissioned by the National Institute for Health and Clinical Excellence (NICE). NICE remains committed to providing a replacement service for CKS and is currently reviewing its options. In the meantime, although CKS content is now not being maintained, it still remains relevant and will continue to be made available. CKS content was generated under a programme of topic creation and update. To check if the topic you are viewing is current or out of date, please refer to the topic publication details by clicking on the 'How up-to-date is this topic?' link in the left hand menu on individual topic pages.

Lyme disease - Background information
What is it?

  • Lyme disease, or Lyme borreliosis, is an infection caused by a group of spiral-shaped bacteria (spirochetes) called Borrelia burgdorferi, which are transmitted to humans following a bite from an infected tick [Hytonen et al, 2008; HPA, 2009d].
    • Early Lyme disease has one or more of the following clinical features: a characteristic erythema migrans rash (also known as erythema chronicum migrans), flu-like symptoms, and neurological, cardiac, and other skin involvement [Wormser et al, 2006].
    • Late Lyme disease is characterized by neurological, joint, or other skin involvement [Wormser et al, 2006].
    • Lyme disease is also reported to trigger a post-infection syndrome, similar to fibromyalgia or chronic fatigue syndrome [HPA, 2009d], although this is controversial [Cameron et al, 2004; Feder et al, 2007].

© NHS Institute for Innovation and Improvement