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Menopause - Management
What advice should I give about the risks and benefits of tibolone?
- Tibolone is effective for treating vasomotor symptoms and reduces the risk of spine fractures. It may also improve sexual functioning.
- Tibolone is associated with a small increased risk of stroke.
- Most studies have shown a small increased risk of having endometrial cancer diagnosed with tibolone use.
- Limited data suggest that tibolone may be associated with a small increased risk of breast cancer, and that tibolone does increase the risk of breast cancer recurrence in women with a history of breast cancer.
- In younger women, the risk profile of tibolone is broadly similar to that for conventional combined hormone replacement therapy.
- For women more than about 60 years of age, the risks associated with tibolone start to outweigh the benefits because of the increased risk of stroke.
In depth
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