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Nausea and vomiting in pregnancy - Evidence
References
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The following references were cited in May 2008. References cited after this date reflect new evidence incorporated since original publication of this topic.
- ABPI Medicines Compendium (2006) Summary of product characteristics for Stugeron 15mg. Electronic Medicines Compendium. Datapharm Communications Ltd. www.emc.medicines.org.uk [Free Full-text]
- ABPI Medicines Compendium (2007a) Summary of product characteristics for Stemetil tablets 5mg. Electronic Medicines Compendium. Datapharm Communications Ltd. www.emc.medicines.org.uk [Free Full-text]
- ABPI Medicines Compendium (2007b) Summary of product characteristics for Stemetil injection. Electronic Medicines Compendium. Datapharm Communications Ltd. www.emc.medicines.org.uk [Free Full-text]
- ABPI Medicines Compendium (2007c) Summary of product characteristics for Phenergan 25mg tablets. Electronic Medicines Compendium. Datapharm Communications Ltd. www.emc.medicines.org.uk [Free Full-text]
- ABPI Medicines Compendium (2007d) Summary of product characteristics for Maxolon tablets. Electronic Medicines Compendium. Datapharm Communications Ltd. www.emc.medicines.org.uk [Free Full-text]
- ACOG (2004) ACOG Practice Bulletin number 52: nausea and vomiting of pregnancy. Obstetrics & Gynecology 103(4), 803-813.
- Berkovitch, M., Elbirt, D., Addis, A. et al. (2000) Fetal effects of metoclopramide therapy for nausea and vomiting of pregnancy. New England Journal of Medicine 343(6), 445-446.
- Berkovitch, M., Mazzota, P., Greenberg, R. et al. (2002) Metoclopramide for nausea and vomiting of pregnancy: a prospective multicenter international study. American Journal of Perinatology 19(6), 311-316. [Abstract]
- BNF 54 (2007) British National Formulary. 54th edn. London: British Medical Association and Royal Pharmaceutical Society of Great Britain.
- Borrelli, F., Capasso, R., Aviello, G. et al. (2005) Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Obstetrics & Gynecology 105(4), 849-856. [Abstract]
- Broussard, C.N. and Richter, J.E. (1998) Nausea and vomiting of pregnancy. Gastroenterology Clinics of North America 27(1), 123-151. [Abstract]
- CEMACH (2007) Saving mothers' lives: reviewing maternal deaths to make motherhood safer - 2003-2005. Confidential Enquiry into Maternal and Child Health. www.cmace.org.uk [Free Full-text]
- Czeizel, A.E., Dudas, I., Fritz, G. et al. (1992) The effect of periconceptional multivitamin-mineral supplementation on vertigo, nausea and vomiting in the first trimester of pregnancy. Archives of Gynecology & Obstetrics 251(4), 181-185.
- Czeizel, A.E., Puho, E., Banhidy, F. and Acs, N. (2004) Oral pyridoxine during pregnancy: potential protective effect for cardiovascular malformations. Drugs in R & D 5(5), 259-269. [Abstract]
- Davis, M. (2004) Nausea and vomiting of pregnancy: an evidence-based review. Journal of Perinatal and Neonatal Nursing 18(4), 312-328. [Abstract]
- Dodds, L., Fell, D.B., Joseph, K.S. et al. (2006) Outcomes of pregnancies complicated by hyperemesis gravidarum. Obstetrics & Gynecology 107(2 Pt 1), 285-292. [Abstract]
- Eliakim, R., Abulafia, O. and Sherer, D.M. (2000) Hyperemesis gravidarum: a current review. American Journal of Perinatology 17(4), 207-218. [Abstract]
- Emelianova, S., Mazzotta, P., Einarson, A. and Koren, G. (2001) Prevalence and severity of nausea and vomiting of pregnancy and effect of vitamin supplementation. Nausea and Vomiting of Pregnancy. www.nvp-volumes.org [Free Full-text]
- Evans, A.T., Samuels, S.N., Marshall, C. et al. (1993) Suppression of pregnancy-induced nausea and vomiting with sensory afferent stimulation. Journal of Reproductive Medicine 38(8), 603-606. [Abstract]
- Festin, M. (2006) Nausea and vomiting in early pregnancy. Clinical Evidence. BMJ Publishing Group Ltd. www.clinicalevidence.com
- Gadsby, R., Barnie-Adshead, A.M. and Jagger, C. (1993) A prospective study of nausea and vomiting during pregnancy. British Journal of General Practice 43(371), 245-248. [Abstract] [Free Full-text]
- Jewell, D. and Young, G. (2003) Interventions for nausea and vomiting in early pregnancy (Cochrane Review). The Cochrane Library. Issue 4. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
- Kallen, B. (2002) Use of antihistamine drugs in early pregnancy and delivery outcome. Journal of Maternal-Fetal & Neonatal Medicine 11(3), 146-152. [Abstract]
- Keating, A. and Chez, R.A. (2002) Ginger syrup as an antiemetic in early pregnancy. Alternative Therapies in Health & Medicine 8(5), 89-91. [Abstract]
- Kuscu, N.K. and Koyuncu, F. (2002) Hyperemesis gravidarum: current concepts and management. Postgraduate Medical Journal 78(916), 76-79. [Abstract] [Free Full-text]
- Magee, L.A., Mazzotta, P. and Koren, G. (2002) Evidence-based view of safety and effectiveness of pharmacologic therapy for nausea and vomiting of pregnancy (NVP). American Journal of Obstetrics and Gynecology 186(5 Suppl Understanding), S256-S261. [Abstract]
- Mahadevan, U. and Kane, S. (2006) American Gastroenterological Association Institute medical position statement on the use of gastrointestinal medications in pregnancy. Gastroenterology 131(1), 278-282. [Abstract] [Free Full-text]
- Micromedex (2007) MICROMEDEX [CD-ROM]. (Vol 131, 1st quarter 2007). Thomson Healthcare.
- Nelson-Piercy, C. (1998) Treatment of nausea and vomiting in pregnancy. When should it be treated and what can be safely taken? Drug Safety 19(2), 155-164. [Abstract]
- NICE (2008) Antenatal care: routine care for the healthy pregnant woman (NICE guideline). National Institute for Health and Clinical Excellence. www.nice.org.uk [Free Full-text]
- NTIS (1999) Nausea and vomiting in pregnancy. Newcastle upon Tyne: National Teratology Information Service, Regional Drug and Therapeutics Centre.
- NTIS (2002) Promethazine exposure during pregnancy. Newcastle upon Tyne: National Teratology Information Service, Regional Drug and Therapeutics Centre.
- Rosen, T., de Veciana, M., Miller, H.S. et al. (2003) A randomized controlled trial of nerve stimulation for relief of nausea and vomiting in pregnancy. Obstetrics & Gynecology 102(1), 129-135. [Abstract]
- Schaefer, C., Peters, P. and Miller, R.K. (Eds.) (2007) Drugs during pregnancy and lactation: treatment options and risk assessment. 2nd edn. Oxford: Academic Press.
- SOGC (2002) SOGC clinical practice guideline. The management of nausea and vomiting of pregnancy. Journal of Obstetrics and Gynaecology Canada 24(10), 817-823. [Free Full-text]
- SOGC (2004) Nausea and vomiting of pregnancy: public education pamphlet. Society of Obstetricians and Gynaecologists of Canada. www.sogc.org [Free Full-text]
- Sorensen, H.T., Nielsen, G.L., Christensen, K. et al. (2000) Birth outcome following maternal use of metoclopramide. The Euromap study group. British Journal of Clinical Pharmacology 49(3), 264-268. [Abstract] [Free Full-text]
- UKMI (2007) How should nausea and vomiting be treated during pregnancy? UK Medicines Information. www.nelm.nhs.uk
- Vutyavanich, T., Kraisarin, T. and Ruangsri, R. (2001) Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial. Obstetrics & Gynecology 97(4), 577-582. [Abstract]
- Whitehead, S.A., Andrews, P.L.R. and Chamberlain, G.V.P. (1992) Characterisation of nausea and vomiting in early pregnancy: a survey of 1000 women. Journal of Obstetrics & Gynaecology 12(6), 364-369.
- Willetts, K.E., Ekangaki, A. and Eden, J.A. (2003) Effect of a ginger extract on pregnancy-induced nausea: a randomised controlled trial. Australian & New Zealand Journal of Obstetrics & Gynaecology 43(2), 139-144. [Abstract]
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