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Nonsteroidal anti-inflammatory drugs (standard or coxibs) - prescribing issues - Management
What should I do for a person who requires clozapine and an NSAID?
- Avoid concomitant use of clozapine with azapropazone, because the risk of agranulocytosis is increased:
- Clozapine can be used with other NSAIDs.
Basis for recommendation
- These recommendations are based on information in the British National Formulary [BNF 55, 2008]:
- Azapropazone is a pyrazolone-type nonsteroidal anti-inflammatory drug (NSAID) [Haddad et al, 2004]. NSAIDs with a different chemical structure are thought not to interact with clozapine.
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