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Nonsteroidal anti-inflammatory drugs (standard or coxibs) - prescribing issues - Management
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Can NSAIDs be used whilst trying to conceive?
- Paracetamol is the analgesic and/or antipyretic of choice during conception.
- The effect of nonsteroidal anti-inflammatory drugs on the chances of conception has not been studied.
- If paracetamol is ineffective, occasional, single doses of an NSAIDs are unlikely to affect the chances of conception.
- However, if a woman is having difficulty conceiving or is undergoing investigation of infertility, the NSAID should be withdrawn.
For more information, contact the UK Teratology Information Service (UKTIS), formerly the National Teratology Information Service (NTIS), on 0844 892 0909.
In depth
Can NSAIDs be used during pregnancy?
- Paracetamol is the analgesic and/or antipyretic of choice during pregnancy.
- However, if during the first or second trimester paracetamol is ineffective and an NSAID is clinically indicated:
- Ibuprofen is the preferred NSAID, but should only be used before 30 weeks of pregnancy (off-label use).
- Use the lowest effective dose for the shortest duration possible.
- If regular use is clinically indicated, such as in a woman with rheumatoid arthritis, seek specialist advice.
- NSAIDs must not be used from 30 weeks of pregnancy onwards without specialist advice and regular fetal monitoring.
For more information, contact the UK Teratology Information Service (UKTIS), formerly the National Teratology Information Service (NTIS), on 0844 892 0909.
In depth
Can NSAIDs be used during breastfeeding?
- Paracetamol is the drug of choice during breastfeeding.
- If a nonsteroidal anti-inflammatory drug is clinically indicated:
- Ibuprofen is the preferred NSAID.
- Use the lowest effective dose, for the shortest time possible.
For more information, see the UK Drugs in Lactation Service website, or telephone 0121 311 1974.
In depth
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