Print Print
CKS is no longer commissioned by the National Institute for Health and Clinical Excellence (NICE). NICE remains committed to providing a replacement service for CKS and is currently reviewing its options. In the meantime, although CKS content is now not being maintained, it still remains relevant and will continue to be made available. CKS content was generated under a programme of topic creation and update. To check if the topic you are viewing is current or out of date, please refer to the topic publication details by clicking on the 'How up-to-date is this topic?' link in the left hand menu on individual topic pages.

Parkinson's disease - Management
How do I manage worsening motor symptoms and motor complications?

  • Worsening motor symptoms or motor complications may include:
    • Deteriorating function — immobility, slowness, withdrawal from activities, communication difficulties.
    • Loss of drug effect.
    • Motor fluctuations — end-of-dose fading (wearing off), on-off phenomenon (rapid and unpredictable fluctuations between 'on' and 'off' periods), or dose failures.
    • Dyskinesia (involuntary movements) — chorea (quick fidgety movements) or dystonia (slow, distorted postures).
    • Freezing of gait.
    • Falls.
  • Look for and treat any acute illness (such as an infection or constipation) that could be exacerbating motor symptoms.
  • Check adherence with anti-parkinsonian medication, including the correct doses and timings.
  • If symptoms or complications persist, contact the person's Parkinson's disease specialist team for advice (on changes to treatment), or make an interim referral.
Basis for recommendation

These recommendations are based on a guide for primary care teams developed by the Parkinson's Disease Society [Parkinson's Disease Society, 2003], with examples of symptoms derived from an evidence-based review [Pahwa et al, 2006].

© NHS Institute for Innovation and Improvement