Print Print
CKS is no longer commissioned by the National Institute for Health and Clinical Excellence (NICE). NICE remains committed to providing a replacement service for CKS and is currently reviewing its options. In the meantime, although CKS content is now not being maintained, it still remains relevant and will continue to be made available. CKS content was generated under a programme of topic creation and update. To check if the topic you are viewing is current or out of date, please refer to the topic publication details by clicking on the 'How up-to-date is this topic?' link in the left hand menu on individual topic pages.

Parkinson's disease - Management
How might a specialist manage motor complications?

Motor complications include:

  • Motor fluctuations — variations or fluctuations in clinical motor response or motor performance.
    • Wearing off of the benefit from levodopa usually at the end of the dosing period, before the next dose is due (this is usually predictable).
    • On–off phenomenon — rapid and unpredictable fluctuations between 'on' and 'off' periods.
  • Dyskinesias — involuntary movements (in response to levodopa or dopamine agonist intake) that may be choreiform (quick, fidgety movements) or dystonic (slow, distorted postures).
    • Peak-dose dyskinesia — dyskinesias occurs at peak-dose levels and are typically choreiform, but may involve dystonia or myoclonus.
    • Diphasic dyskinesia — dyskinesias occur at the beginning of turning 'on' and/or at the beginning of turning 'off', but they are different, less severe, or absent at the time of peak levodopa effect.
    • Off-state dystonia — dystonia when plasma levodopa levels are low.
  • Freezing of gait — inability to start or continue walking, characterized by difficulty in stepping forward (at initiation or during walking), inability to lift the foot from the floor, and trembling of the legs.
    • Freezing of gait is a common cause of falls, particularly as there is an associated disturbance of balance.
    • Freezing of gait occurs during the 'off' phase and, less frequently, in both 'off' and 'on' phases.

[Horstink et al, 2006; Chou, 2008; Dewey, 2008; Okuma and Yanagisawa, 2008]

© NHS Institute for Innovation and Improvement