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Smoking cessation - Management
Which drug interactions are relevant for bupropion?
- Co-administration of bupropion with other drugs known to lower the seizure threshold will increase the likelihood of seizures and should only be done under exceptional circumstances. Such drugs include antipsychotics; antidepressants; some antimalarials, such as mefloquine; theophylline; systemic corticosteroids; tramadol; quinolones; and sedating antihistamines [CSM, 2001b].
- Bupropion should not be given within 2 weeks of stopping a monoamine oxidase inhibitor (MAOI). For moclobemide (a reversible MAOI), this period can be reduced to 2–3 days [Baxter, 2006].
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