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Sore throat - acute - Management
When should I prescribe an antibiotic for sore throat?

  • Do not routinely prescribe antibiotics for acute sore throat.
    • Antibiotics should not be prescribed to:
      • Secure symptomatic relief.
      • Prevent suppurative complications.
      • Treat recurrent non-streptococcal sore throat.
      • Prevent the development of rheumatic fever and acute glomerulonephritis.
    • Consider a delayed antibiotic prescribing strategy for people with sore throat where it is felt safe not to prescribe antibiotics immediately.
      • Reassure the person that antibiotics are not needed immediately as they will make little difference to symptoms, and may have adverse effects.
      • Advise the person to use the delayed prescription if symptoms do not settle or get significantly worse.
      • Advise the person about the need for review if symptoms get significantly worse despite using the delayed prescription.
  • Consider a 2 or 3-day delayed prescription or immediate antibiotics for people with a sore throat and a Centor score of 3 or 4 (presence of tonsillar exudate, tender anterior cervical lymphadenopathy or lymphadenitis, history of fever, and absence of cough).
  • Prescribe an antibiotic for:
    • Those with features of marked systemic upset.
    • Those at increase risk of serious complications.
    • Those with valvular heart disease.
  • Have a low threshold for prescribing an antibiotic in people:
    • With an increased risk of severe infection (e.g. diabetes or immunocompromised).
    • Who are at risk of immunosuppression (e.g. on disease-modifying anti-rheumatic drugs [DMARDs], carbimazole).
    • With a history of rheumatic fever.
  • People with peritonsillar abscess or peritonsillar cellulitis will receive antibiotics in secondary care: admit immediately.
  • An antibiotic may be useful in:
    • Preventing cross-infections with group A beta-haemolytic streptococcus (GABHS) in closed institutions such as barracks or boarding schools. However, it should not be used routinely to prevent cross-infection in the general community.
    • Treating recurrent sore throat associated with GABHS.

In depth

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