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Urinary tract infection (lower) - men - Management
What drug interactions should I be aware of with nitrofurantoin?
- The use of alkalinizing agents (such as potassium citrate) should be avoided in people taking nitrofurantoin. The antibacterial activity of nitrofurantoin is reduced when the pH of the urine is increased [SIGN, 2006].
- Although the manufacturer of nitrofurantoin advises against concomitant administration of magnesium trisilicate with nitrofurantoin (due to reduced absorption), the clinical significance is uncertain as only one very small study in six people has reported this effect [Baxter, 2008].
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