CKS is no longer commissioned by the National Institute for Health and Clinical Excellence (NICE). NICE remains committed to providing a replacement service for CKS and is currently reviewing its options. In the meantime, although CKS content is now not being maintained, it still remains relevant and will continue to be made available. CKS content was generated under a programme of topic creation and update. To check if the topic you are viewing is current or out of date, please refer to the topic publication details by clicking on the 'How up-to-date is this topic?' link in the left hand menu on individual topic pages.
Urinary tract infection (lower) - men - Management
What drug interactions should I be aware of with trimethoprim?
The following drug interactions have been reported with trimethoprim, when it is combined:
- With phenytoin
- There is a small risk of phenytoin toxicity (particularly if the serum phenytoin levels are at the top end of the range) as trimethoprim can decrease the clearance of phenytoin [Baxter, 2008]. Signs of phenytoin toxicity include blurred vision, nystagmus, ataxia, or drowsiness.
- With ciclosporin
- Increased nephrotoxicity has been reported. However, this interaction has not been firmly established.
[Baxter, 2008; BNF 57, 2009]
© NHS Institute for Innovation and Improvement