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Urticaria - Management
What are the possible trigger factors for urticaria?

  • Advise people to reduce or avoid factors that are known to exacerbate their urticarial rash, that may include:
    • Stress
    • Alcohol, caffeine, spices, and hot water
    • Some foods (e.g. fish, shellfish, nuts, cheese) and food additives (e.g. dietary salicylates, azo dyes, and benzoic acid).
      • Food is often overestimated as a cause — in genuine food allergy, symptoms usually occur reproducibly within 60 minutes of exposure to the offending food. Food diaries may be helpful but can be hard to interpret.
    • Overheating — keep the bedroom cool whilst sleeping and avoid hot baths.
    • Tight clothing
    • Medication — e.g. aspirin, codeine, nonsteroidal anti-inflammatory drugs (NSAIDs), and angiotensin-converting enzyme (ACE) inhibitors. Advise people not to use cold remedies or herbal preparations until the exacerbating factors have been excluded.
    • Insect bites and stings — remove the stinger after a bee or wasp sting as soon as possible. Advise people to wear long-sleeved clothing and to avoid wearing bright colours or perfume.
Basis for recommendation
  • Stress is an important precipitant of urticaria. In one small non-randomized study, relaxation therapy and hypnosis improved self-reported symptoms but not the number of observed weals [Shertzer and Lookingbill, 1987].
  • Diets and food avoidance remain controversial with very little evidence to support their benefit in people with urticaria [Zachariae et al, 1969; Kozel and Sabroe, 2005]. Food can usually be excluded as a cause of urticaria if there is no temporal relationship to a particular food trigger, either by ingestion or contact. In genuine food allergy, symptoms usually occur reproducibly within 60 minutes of exposure to the offending food [Powell et al, 2007].
  • Alcohol, caffeine, spices, and hot water all cause vasodilation and may precipitate urticaria [Moses, 2003].
  • Overheating commonly exacerbates itch, so advise keeping the bedroom cool at night whilst sleeping, and avoiding hot baths [Moses, 2003].
  • Tight clothing should be avoided in delayed-pressure urticaria. This minimizes sweating which is thought to be an important precipitant of the symptom of itch [Yosipovitch et al, 2002].
  • Medication — if possible avoid drugs such as aspirin (not contraindicated in urticaria but the reaction is dose-dependent), codeine, nonsteroidal anti-inflammatory drugs (NSAIDs), and angiotensin-converting enzyme (ACE) inhibitors. Advise people not to use cold remedies or herbal preparations until the exacerbating factors have been excluded [BAD, 2006]. For more information, see the CKS topic on Angio-oedema and anaphylaxis.

[Kozel and Sabroe, 2005]

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